Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 278, Issue -, Pages 563-568Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.10.028
Keywords
Orexin; SB-334867; Defensive behavior; c-Fos immunohistochemistry; Dorsal premammillary nucleus; Paraventricular hypothalamus
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Funding
- Macquarie University Faculty of Human Sciences Research Fellowship
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Increasing evidence suggests that the orexin system is involved in modulating anxiety, and we have recently shown that cat odor-induced anxiety in rats is attenuated by the orexin receptor antagonist SB-334867. In the current experiment, c-Fos expression was used to map changes in neuronal activation following SB-334867 administration in the cat odor anxiety model. Male Wistar rats were exposed to cat odor with or without SB-334867 pre-treatment (10 mg/kg, i.p.). A naive control group not exposed to cat odor was also used. Following cat odor exposure, brains were processed for c-Fos expression. Vehicle-treated rats showed an increase in anxiety-like behaviors (increased hiding and decreased approach toward the cat odor), and increased c-Fos expression in the posteroventral medial amygdala (MePV), paraventricular hypothalamus (PVN) and dorsal premammillary nucleus (PMd). In rats pretreated with SB-334867, approach scores increased and c-Fos expression decreased in the PVN and PMd. These results provide both behavioral and neuroanatomical evidence for the attenuation of cat odor-induced anxiety in rats via the orexin system. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.
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