Article
Environmental Sciences
Yassine Ait Bali, Nour-Eddine Kaikai, Saadia Ba-M'hamed, Marco Sassoe-Pognetto, Maurizio Giustetto, Mohamed Bennis
Summary: Evidence demonstrates that serotonin depletion leads to anxiety behavior. Previous studies have also shown that glyphosate-based herbicides increase anxiety levels and reduce serotonin fibers in exposed mice. In this study, the effects of herbicides on immediate early gene activation in the mPFC and amygdala were investigated, revealing anxiogenic behavior in exposed mice.
Review
Chemistry, Medicinal
Mi Wang, Xian Zhao, Pengfei Yin, Xiuxia Bao, Hongli Tang, Xianhui Kang
Summary: Remimazolam is a novel sedative drug with promising application prospects. It has distinct advantages compared to other drugs, particularly for elderly individuals, patients with critical diseases, or patients with liver and kidney insufficiency. The current study reviews recent clinical studies on remimazolam and summarizes its characteristics of applications, aiming to provide scientific support for its clinical application in the field of anesthesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Clinical Neurology
Masahiro Takeshima, Kazuhisa Yoshizawa, Minori Enomoto, Masaya Ogasawara, Mizuki Kudo, Yu Itoh, Naoko Ayabe, Yoshikazu Takaesu, Kazuo Mishima
Summary: This study aimed to examine the effect of Japanese policies and novel hypnotics on long-term prescriptions of hypnotics. The results showed that Japanese policies had no statistically significant effect on long-term prescriptions of hypnotics. However, initiating orexin receptor antagonists may be a potential strategy to prevent long-term prescriptions of hypnotics.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Neurosciences
Renata M. Felippe, Gabriel M. Oliveira, Rafaela S. Barbosa, Betina D. Esteves, Beatriz M. S. Gonzaga, Samuel I. M. Horita, Luciana R. Garzoni, Daniela G. Beghini, Tania C. Araujo-Jorge, Viviane M. S. Fragoso
Summary: Aggression is defined as hostile behavior that causes psychological damage, injury, and even death among individuals, and when it presents itself in an exacerbated and constant manner, it can be considered escalating or pathological. The association between social stress and exacerbated aggressiveness is suggested to be interconnected through complex neurobiological factors, such as alterations in dopaminergic receptors, ROS production, and c-Fos protein expression. In mice, exacerbated aggression is linked to social stress, dysregulation of the dopaminergic system, and increased ROS production, leading to cellular oxidative stress. The overexpression of c-Fos due to social stress indicates an attempt by cells to produce antioxidant agents to reduce toxic ROS concentrations.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Abhishek G. Sathe, Ellen Underwood, Lisa D. Coles, Jordan J. Elm, Robert Silbergleit, James M. Chamberlain, Jaideep Kapur, Hannah R. Cock, Nathan B. Fountain, Shlomo Shinnar, Daniel H. Lowenstein, Eric S. Rosenthal, Robin A. Conwit, Thomas P. Bleck, James C. Cloyd
Summary: This study aimed to describe patterns of benzodiazepine use as first-line treatment of status epilepticus (SE) and found that benzodiazepines, particularly midazolam and lorazepam, are frequently underdosed throughout the United States. The study confirmed that underdosing is pervasive and difficult to remediate.
Article
Multidisciplinary Sciences
Aleksandra Karewicz, Katarzyna Faber, Katarzyna Karon, Katarzyna Januszewska, Joanna Ryl, Piotr Korczynski, Katarzyna Gorska, Marta Dabrowska, Rafal Krenke
Summary: Low anxiety levels before bronchoscopy and reduced discomfort during the procedure are associated with better patient satisfaction. Therefore, it is important to reduce patient anxiety and discomfort during the procedure.
Article
Geriatrics & Gerontology
Jay A. Brieler, Joanne Salas, Matthew E. Amick, Poorva Sheth, Elizabeth A. Keegan-Garrett, John E. Morley, Jeffrey F. Scherrer
Summary: The use of benzodiazepines in older patients is controversial. Anxiety disorders and benzodiazepines have been linked to dementia, but the literature is inconsistent. It is unclear whether treating anxiety with benzodiazepines, compared to anxiety disorder alone, is associated with an increased risk of dementia.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Substance Abuse
T. MacDonald, A. T. Gallo, G. Basso-Hulse, K. S. Bennett, G. K. Hulse
Summary: Low-dose subcutaneous flumazenil may help reduce BZD use and withdrawal symptoms in participants taking daily diazepam equivalent doses greater than or equal to the therapeutic maximum (>30 mg) by reducing the need for diazepam.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Pharmacology & Pharmacy
Lalit K. Golani, Donna M. Platt, Daniela Ruedi-Bettschen, Chitra Edwanker, Shenming Huang, Michael M. Poe, Roman Furtmueller, Werner Sieghart, James M. Cook, James K. Rowlett
Summary: In an effort to develop improved anxiolytic drugs, synthesized 8-substituted analogs of triazolam were evaluated for selectivity towards alpha 2/alpha 3 subunit-containing GABA(A) subtypes. While no selectivity was observed in binding assays, SH-TRI-108 showed significant functional potency differences between alpha 1 beta 3 gamma 2 and alpha 2 beta 3 gamma 2 subtypes. Behavioral pharmacological differences were observed in monkeys, with SH-TRI-108 demonstrating anti-conflict effects and sedative-motor effects similar to triazolam in squirrel monkeys.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Psychiatry
Masahiro Takeshima, Yumi Aoki, Kenya Ie, Eiichi Katsumoto, Eichi Tsuru, Takashi Tsuboi, Ken Inada, Morito Kise, Koichiro Watanabe, Kazuo Mishima, Yoshikazu Takaesu
Summary: This study investigated the prescribing habits and reasons for selection of hypnotics among 962 physicians. The results showed that the most frequently prescribed hypnotic was an orexin receptor antagonist (ORA), followed by non-benzodiazepines, melatonin receptor agonists (MRA), and benzodiazepines. Physicians who frequently prescribed ORA were more concerned with efficacy and safety, while those who frequently prescribed MRA and non-benzodiazepines were more concerned with safety, and those who frequently prescribed benzodiazepines were more concerned with efficacy but less concerned with safety.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Toshiro Io, Rob Saunders, Marija Pesic, Karl-Uwe Petersen, Thomas Stoehr
Summary: Research suggests that in NIBS micropigs, remimazolam has lower tolerance than midazolam and faster recovery times, making it suitable as a model for evaluating the drug.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Yuan-Yuan Han, Jian-Wen Zhou, Zhi-Wei Guo, Zhuo-Qing Wu, Zai-Yong Zhang, De-xiang Liu, Cheng Long
Summary: CYLD, a lysine 63 deubiquitinase, is highly expressed in the brain and is associated with anxious and depressive behavior, cognitive inflexibility, and autism disorders. Previous research was limited to certain brain regions and this study aimed to understand its role in adaptation to stress and identify the involved brain regions. The study found that CYLD deficiency unexpectedly affected the reaction to acute restraint stress in mice, leading to neuronal activation in specific brain regions such as the medial prefrontal cortex, dorsal striatum, nucleus accumbens, and basal lateral amygdala, while not involving the ventral hippocampus.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
Article
Neurosciences
Sakineh Alijanpour, Ameneh Rezayof
Summary: This study aimed to investigate whether activation of the ventral hippocampal CB1 cannabinoid receptors affects the anxiety-like behaviors induced by ketamine. The results showed that ketamine administration caused anxiogenic-like behavior, but activation of the VH CB1 receptors inhibited these behaviors. Additionally, the levels of BDNF and c-Fos proteins in the hippocampus were altered after ketamine and ACPA treatment.
Article
Behavioral Sciences
Alejandro Borja Grau-Perales, Fernando Gamiz, Milagros Gallo
Summary: Research has shown that the hippocampal administration of 6-OHDA disrupts context-dependent taste recognition memory, indicating that auditory background can modulate safe taste memory acquisition through catecholaminergic activity in the hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Neurosciences
Syed Umar Hasan, Alina Pervez, Shaheen Bhatty, Shifa Shamim, Aaima Naeem, Muhammad Wahdan Naseeb
Summary: This network meta-analysis compares different benzodiazepines and their routes of administration on the treatment of seizures. The results show that intramuscular midazolam has the best efficacy in successful seizure cessation, while intranasal midazolam has the best performance in total time for cessation. Intravenous lorazepam is more promising for patients with an established intravenous line, while intranasal midazolam should be the first-line treatment for patients presenting in the emergency room without an intravenous line.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Gian Marco Leggio, Roberta Di Marco, Walter Gulisano, Marcello D'Ascenzo, Sebastiano Alfio Torrisi, Federica Geraci, Gianluca Lavanco, Kristiina Dahl, Giovanni Giurdanella, Alessandro Castorina, Teemu Aitta-aho, Giuseppe Aceto, Claudio Bucolo, Daniela Puzzo, Claudio Grassi, Esa R. Korpi, Filippo Drago, Salvatore Salomone
PHARMACOLOGICAL RESEARCH
(2019)
Editorial Material
Neurosciences
Esa R. Korpi, Dan Lindholm, Pertti Panula, Pentti J. Tienari, Matti Haltia
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Maria Lindahl, Alcmene Chalazonitis, Erik Palm, Emmi Pakarinen, Tatiana Danilova, Tuan D. Pham, Wanda Setlik, Meenakshi Rao, Vootele Voikar, Jatta Huotari, Jaakko Kopra, Jaan-Olle Andressoo, Petteri T. Piepponen, Mikko Airavaara, Anne Panhelainen, Michael D. Gershon, Mart Saarma
NEUROBIOLOGY OF DISEASE
(2020)
Article
Pharmacology & Pharmacy
Shamsiiat Abdurakhmanova, Milo Grotell, Jenna Kauhanen, Anni-Maija Linden, Esa R. Korpi, Pertti Panula
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biology
Elina Nagaeva, Ivan Zubarev, Carolina Bengtsson Gonzales, Mikko Forss, Kasra Nikouei, Elena de Miguel, Lauri Elsila, Anni-Maija Linden, Jens Hjerling-Leffler, George J. Augustine, Esa R. Korpi
Article
Clinical Neurology
Piotr Chmielarz, Safak Er, Julia Konovalova, Laura Bandres, Irena Hlushchuk, Katrina Albert, Anne Panhelainen, Kelvin Luk, Mikko Airavaara, Andrii Domanskyi
MOVEMENT DISORDERS
(2020)
Article
Psychiatry
Francesca Morello, Vootele Voikar, Pihla Parkkinen, Anne Panhelainen, Marko Rosenholm, Aki Makkonen, Tomi Rantamaki, Petteri Piepponen, Teemu Aitta-aho, Juha Partanen
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Clinical Neurology
Sara Konstantin Nissen, Sara Almeida Ferreira, Marlene Christina Nielsen, Claudia Schulte, Kalpana Shrivastava, Dorle Hennig, Anders Etzerodt, Jonas Heilskov Graversen, Daniela Berg, Walter Maetzler, Anne Panhelainen, Holger Jon Moller, Kathrin Brockmann, Marina Romero-Ramos
Summary: This study found that sCD163 in the CSF of PD patients correlated with PD biomarkers and cognition scores, supporting monocyte involvement in neurodegeneration and cognition in PD. An increase in CSF-sCD163 in female patients suggested a sex-distinctive monocyte response. In vitro studies showed the potential connection between CD163 and alpha-synuclein, indicating a role for monocytes in both peripheral and brain immune responses to PD.
MOVEMENT DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Lauri Elsila, Nuppu Korhonen, Petri Hyytia, Esa R. Korpi
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Milo Grotell, Bjornar den Hollander, Aaro Jalkanen, Essi Torronen, Jouni Ihalainen, Elena de Miguel, Mateusz Dudek, Mikko I. Kettunen, Petri Hyytia, Markus M. Forsberg, Esko Kankuri, Esa R. Korpi
Summary: Despite not being neurotoxic on its own, 4-MMC can potentially induce neurotoxicity under certain conditions and when combined with alcohol. The substance causes widespread deactivation of neural activity when used with ethanol, resembling the effects of neurotoxic METH. While 4-MMC has minimal long-term effects when used alone, its co-administration with ethanol leads to profound functional adaptations similar to those seen with neurotoxic METH.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Milo Grotell, Shamsiiat Abdurakhmanova, Lauri V. Elsila, Esa R. Korpi
Summary: The delta subunit-containing gamma-aminobutyric acid A-type receptors (delta-GABA(A)Rs) are thought to play important roles in brain functions and their modulation can affect behaviors in animals. Pharmaco-EEG experiments indicate that drugs interacting with these receptors may impact brain wave frequencies and influence behavioral responses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kart Matlik, Daniel R. Garton, Ana R. Montano-Rodriguez, Soophie Olfat, Feride Eren, Laoise Casserly, Anastasios Damdimopoulos, Anne Panhelainen, L. Lauriina Porokuokka, Jaakko J. Kopra, Giorgio Turconi, Nadine Schweizer, Erika Bereczki, Fredrik Piehl, Goran Engberg, Simon Cervenka, T. Petteri Piepponen, Fu-Ping Zhang, Petra Sipila, Johan Jakobsson, Carl M. Sellgren, Sophie Erhardt, Jaan-Olle Andressoo
Summary: This study found that increased striatal dopamine signaling in a subgroup of schizophrenia patients may be related to the increase of GDNF. A possible mediator of GDNF-driven dopaminergic abnormalities is A(2A)R. By inhibiting A(2A)R with a drug, striatal and cortical dopamine levels can be partially normalized. These results provide potential therapeutic targets for the treatment of schizophrenia.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Lauri Elsila, Juliana Harkki, Emma Enberg, Alvar Martti, Anni-Maija Linden, Esa R. Korpi
Summary: Acute administration of 0.1 mg/kg LSD transiently decreases binge-like ethanol drinking in mice, but has no effect on sucrose drinking. LSD does not affect the intracranial self-stimulation threshold or the rewarding effects of simultaneous amphetamine treatment, but has small, acute diminishing effects on food and water intake.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Freja Frankenhaeuser, Birgitta Soeder, Hakan Kaellmen, Esa R. Korpi, Jukka H. Meurman
Summary: This study investigated the association between periodontitis and purchases of medications in the long term. The results showed that patients with periodontitis purchased significantly more drugs in certain categories compared to periodontally healthy individuals. This suggests that periodontitis may increase the risk for systemic diseases and the need for medication.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Elina Nagaeva, Ivan Zubarev, Esa R. Korpi
Summary: Characterization of electrically active cells such as neurons requires measurement of their electrical properties. Patch-clamp technique can be used to measure these features, but detailed post-hoc analysis of firing patterns can be time-consuming. Various laboratories have their own methods, but this article introduces a software for fast and convenient analysis of firing patterns.
Article
Behavioral Sciences
Amine Bahi
Summary: Gestational environmental enrichment (EE) has protective effects on social stress-induced anxiety-like behaviors and excessive ethanol consumption through increasing BDNF levels.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
David R. Maguire
Summary: The study found that Lorcaserin alone reduces ventilation and enhances the ventilatory-depressant effects of opioids. This suggests that combining a 5-HT2C receptor agonist with opioids may increase the risk of ventilatory depression without reducing abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Summary: This study demonstrates the attenuating effect of H2S on PD-associated depression by improving hippocampal synaptic plasticity.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
Summary: This study investigated the effects of lithium on freezing behavior and pain perception in a fear-conditioning model in rats. The results showed that lithium had no effect on freezing behavior and pain subthreshold in all rats. Extinction training decreased freezing behavior, with more efficacy in females. Gender differences were also observed in the effects of extinction training.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)