Article
Multidisciplinary Sciences
Han-Tao Li, Dane C. Donegan, Daria Peleg-Raibstein, Denis Burdakov
Summary: This study explores a deep brain stimulation (DBS) strategy for modulating anxiety symptoms by targeting the lateral hypothalamus (LH). The researchers identify a DBS waveform that inhibits anxiety-related neural activity and suppresses anxiety behaviors in mouse models without any noticeable side effects. These findings suggest that acute hypothalamic DBS could be a potential strategy for managing treatment-resistant anxiety disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Dane Donegan, Christoph M. Kanzler, Julia Buescher, Paulius Viskaitis, Ed F. Bracey, Olivier Lambercy, Denis Burdakov
Summary: Skilled arm movements require adaptation based on sensory errors, and studies in mice show that forelimb motor adaptation is regulated by the hypothalamic orexin/hypocretin neurons (HONs). By studying goal-oriented mouse-robot interactions, distinct HON signals were found during forelimb movements and motor adaptation. Temporally-delimited optosilencing of these movement-associated HON signals impaired sensory error-based motor adaptation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Oncology
Yinxian Wen, Siyuan Cheng, Juan Lu, Xia He, Zhexiao Jiao, Dan Xu, Hui Wang
Summary: Prenatal food restriction (PFR) leads to dysfunction of the HPA axis in adult offspring, characterized by hypothalamic hyperexcitability and poor hippocampal feedback, which affect the behavior of the rat offspring.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chang-Hong Liu, Bo-Lun Zhao, Wen-Tao Li, Xiao-Hua Zhou, Zhe Jin, Li-Bin An
Summary: Reduction in sucrose preference, impaired motor function, increased depressive-like behaviors, hyperactivation of the hypothalamic-pituitary-adrenal axis, and inhibition of adult hippocampal neurogenesis may contribute to depressive-like behaviors after spinal cord injury in rats.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jian Zhong Yang, Chuan Yuan Kang, Jing Yuan, Yan Zhang, Yu Jun Wei, Li Xu, Fang Zhou, Xinxin Fan
Summary: This study highlighted that patients with major depressive disorder (MDD) who experienced adverse childhood experiences (ACEs) showed differences in hypothalamic-pituitary-adrenal (HPA) axis function and symptom severity compared to those without ACEs. ACEs, ACTH, and COR could serve as predictors for long-term antidepressant treatment, suggesting that they may be poor prognostic indicators for MDD patients with ACEs.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tzu-Ling Li, Yen-Hsien Lee, Feng-Hsu Wu, Ling-Ling Hwang
Summary: Orexin-A directly excites over half of DMH neurons, including those innervating the RVLM, through decreasing K+ conductance, activating NCX, and/or increasing NSCC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feiye Wu, Jing Zhu, Yang Wan, Subinuer Kurexi, Jia Zhou, Ke Wang, Tongyu Chen
Summary: This study aimed to investigate the effects of electroacupuncture (EA) on the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its potential mechanisms. The results showed that EA treatment effectively inhibited the hyperactivity of the HPA axis and promoted postoperative recovery by activating the oxytocin/oxytocin receptor (OXT/OXTR) signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Dmitrii D. Markov, Oleg V. Dolotov, Igor A. Grivennikov
Summary: Major depression is a prevalent mental disorder that causes significant suffering and economic loss. Conventional antidepressants are not effective enough, and there is a need for new medications. The underlying causes of depression, such as brain monoamine imbalance and dysregulation of the hypothalamic-pituitary-adrenal axis, remain poorly understood. This review explores the potential of targeting the melanocortin system to address these disturbances and potentially provide a promising antidepressant approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mathieu Nollet, Harriet Hicks, Andrew P. McCarthy, Huihai Wu, Carla S. Moller-Levet, Emma E. Laing, Karim Malki, Nathan Lawless, Keith A. Wafford, Derk-Jan Dijk, Raphaelle Winsky-Sommerer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Neurosciences
Kelly Perlman, Charles P. Couturier, Moein Yaqubi, Arnaud Tanti, Qiao-Ling Cui, Florian Pernin, Jo Anne Stratton, Jiannis Ragoussis, Luke Healy, Kevin Petrecca, Roy Dudley, Myriam Srour, Jeffrey A. Hall, Timothy E. Kennedy, Naguib Mechawar, Jack P. Antel
Review
Neurosciences
Romain Troubat, Pascal Barone, Samuel Leman, Thomas Desmidt, Arnaud Cressant, Boriana Atanasova, Bruno Brizard, Wissam El Hage, Alexandre Surget, Catherine Belzung, Vincent Camus
Summary: Neuroinflammation interacts with key neurobiological factors of depression, potentially presenting a crucial therapeutic target for future treatments. This interaction may impact serotonin levels, HPA axis regulation, and hippocampal neurogenesis, leading to the pathophysiological cascade of increased glutamate levels and altered neurotransmission. It can be triggered by chronic inflammatory conditions or primary brain neuroinflammation, highlighting the importance of addressing neuroinflammation in the treatment of major depressive disorder.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Corina Nagy, Malosree Maitra, Arnaud Tanti, Matthew Suderman, Jean-Francois Theroux, Maria Antonietta Davoli, Kelly Perlman, Volodymyr Yerko, Yu Chang Wang, Shreejoy J. Tripathy, Paul Pavlidis, Naguib Mechawar, Jiannis Ragoussis, Gustavo Turecki
NATURE NEUROSCIENCE
(2020)
Review
Biology
Mathieu Nollet, William Wisden, Nicholas P. Franks
Article
Anatomy & Morphology
Liam Anuj O'Leary, Maria Antonietta Davoli, Claudia Belliveau, Arnaud Tanti, Jie Christopher Ma, William Todd Farmer, Gustavo Turecki, Keith Kazuo Murai, Naguib Mechawar
FRONTIERS IN NEUROANATOMY
(2020)
Article
Immunology
Romain Troubat, Samuel Leman, Katleen Pinchaud, Alexandre Surget, Pascal Barone, Sebastien Roger, Anne-Marie Le Guisquet, Bruno Brizard, Catherine Belzung, Vincent Camus
Summary: After exposure to UCMS, P2X7R KO mice showed significant differences in behavioral and neurogenesis compared to the control group, as well as notable changes in the density of brain immune cells. The recruitment rate of peripheral immune cells was unaffected by P2X7R gene expression or antidepressant treatment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
A. Surget, C. Belzung
Summary: Adult hippocampal neurogenesis plays a crucial role in shaping adaptation to environmental demands and enhancing conjunctive encoding and pattern separation in the hippocampus, reducing proactive interference and generalization of stressful experiences. This process ultimately enables more accurate and contextualized information to be transmitted to downstream brain areas, facilitating appropriate setting of the stress response in specific contexts.
MOLECULAR PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Yadira Ibarguen-Vargas, Samuel Leman, Rupert Palme, Catherine Belzung, Alexandre Surget
Summary: Despite showing promise initially, CRF-R1 antagonists have not been effective in clinical trials for anxiety or depression. These drugs may be more beneficial in single stressful situations or for individuals with chronic stress conditions. Although they can improve negative feedback in chronically stressed individuals, long-term use of CRF-R1 antagonists may lead to overactivation of the HPA axis, raising concerns about potential physiological outcomes under ongoing chronic stress.
Article
Multidisciplinary Sciences
Xiao Yu, Guangchao Zhao, Dan Wang, Sa Wang, Rui Li, Ao Li, Huan Wang, Mathieu Nollet, You Young Chun, Tianyuan Zhao, Raquel Yustos, Huiming Li, Jianshuai Zhao, Jiannan Li, Min Cai, Alexei L. Vyssotski, Yulong Li, Hailong Dong, Nicholas P. Franks, William Wisden
Summary: Social defeat stress induces sleep in mice, and a subset of VTA(Vgat-Sst) cells plays a crucial role in promoting and maintaining sleep through a specific neural circuit, while also inhibiting CRF release after stress.
Article
Psychiatry
Georgine Accrombessi, Laurent Galineau, Clovis Tauber, Sophie Serriere, Esteban Moyer, Bruno Brizard, Anne-Marie Le Guisquet, Alexandre Surget, Catherine Belzung
Summary: This study revealed the association between behavioral phenotypes of adolescent subthreshold depression and metabolic activity changes in specific brain regions in an animal model. These findings provide neural signatures for predicting subthreshold depression in adolescents.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Thomas Desmidt, Paul-Armand Dujardin, Frederic Andersson, Bruno Brizard, Jean-Pierre Remenieras, Valerie Gissot, Nicolas Arlicot, Laurent Barantin, Fabien Espitalier, Catherine Belzung, Arnaud Tanti, Gabriel Robert, Samuel Bulteau, Quentin Gallet, Francois Kazour, Sandrine Cognet, Vincent Camus, Wissam El-Hage, Pierre Poupin, Helmet T. Karim
Summary: Nitrous oxide (N2O) has been found to be a potential rapid-acting antidepressant, but the brain mechanisms underlying its effects remain speculative. Our study showed that a single session of an Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) could modify functional connectivity in specific brain regions and increase brain tissue pulsations (BTP). We found that responders to EMONO showed reduced connectivity between the subgenual ACC and the precuneus, as well as increased BTP, suggesting potential markers for antidepressant response.
MOLECULAR PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Arnaud Tanti, Corina Nagy, Malosree Maitra, Marina Wakid, Gustavo Turecki, Naguib Mechawar
BIOLOGICAL PSYCHIATRY
(2020)
Meeting Abstract
Neurosciences
Corina Nagy, Malosree Maitra, Arnaud Tanti, Matthew Suderman, Jean-Francois Theroux, Shreejoy Tripathy, Paul Pavlidis, Naguib Mechawar, Gustavo Turecki
BIOLOGICAL PSYCHIATRY
(2020)