The SF3b complex: splicing and beyond

Knockdown of PHF5A Inhibits Migration and Invasion of HCC Cells via Downregulating NF-κB Signaling

(2019) Qing Yang et al.   Biomed Research International

A U2-snRNP–independent role of SF3b in promoting mRNA export

(2019) Ke Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching

(2019) Ruixue Wan et al.   CELL

Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A

(2019) Zhe Wang et al.   MOLECULAR CELL

Component of splicing factor SF3b plays a key role in translational control of polyribosomes on the endoplasmic reticulum

(2019) Tomonori Ueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of 5ʹ splice site transfer for human spliceosome activation

(2019) Clément Charenton et al.   SCIENCE

Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?

(2019) Simon Boudreault et al.   Wiley Interdisciplinary Reviews-RNA

PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing

(2019) Shuangshuang Mao et al.   Cancer Medicine

SF3B2-mediated RNA splicing drives human prostate cancer progression

(2019) Norihiko Kawamura et al.   CANCER RESEARCH

Structures of SF3b1 reveal a dynamic Achilles heel of spliceosome assembly: Implications for cancer-associated abnormalities and drug discovery

(2019) Debanjana Maji et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structural and functional modularity of the U2 snRNP in pre-mRNA splicing

(2019) Clarisse van der Feltz et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1

(2019) Jian Zhang et al.   MOLECULAR CELL

PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression.

(2018) Yi-Zi Zheng et al.   CANCER RESEARCH

Structure and Conformational Dynamics of the Human Spliceosomal B act Complex

(2018) David Haselbach et al.   CELL

Structure of the human activated spliceosome in three conformational states

(2018) Xiaofeng Zhang et al.   CELL RESEARCH

Insights from structures of cancer-relevant pre-mRNA splicing factors

(2018) Clara L Kielkopf   CURRENT OPINION IN GENETICS & DEVELOPMENT

The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

(2018) Lorenzo I. Finci et al.   GENES & DEVELOPMENT

Barrier to autointegration factor 1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as early-stage cancer decision markers and drivers of hepatocellular carcinoma

(2018) Qingyu Shen et al.   HEPATOLOGY

PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma

(2018) Yan Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

(2018) Constantin Cretu et al.   MOLECULAR CELL

Functional analysis of Hsh155/SF3b1 interactions with the U2 snRNA/branch site duplex

(2018) Tucker J. Carrocci et al.   RNA

Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation

(2018) Rui Bai et al.   SCIENCE

Prespliceosome structure provides insights into spliceosome assembly and regulation

(2018) Clemens Plaschka et al.   NATURE

Structures of the human pre-catalytic spliceosome and its precursor spliceosome

(2018) Xiechao Zhan et al.   CELL RESEARCH

Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress

(2017) Veena Mathew et al.   JOURNAL OF CELL BIOLOGY

Structure of a pre-catalytic spliceosome

(2017) Clemens Plaschka et al.   NATURE

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

(2017) Karl Bertram et al.   NATURE

SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast

(2017) Tucker J. Carrocci et al.   NUCLEIC ACIDS RESEARCH

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

(2017) Teng Teng et al.   Nature Communications

Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

(2016) Esther A. Obeng et al.   CANCER CELL

Sf3b4-depleted Xenopus embryos: A model to study the pathogenesis of craniofacial defects in Nager syndrome

(2016) Arun Devotta et al.   DEVELOPMENTAL BIOLOGY

SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing

(2016) Qing Tang et al.   GENES & DEVELOPMENT

IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease

(2016) Hao Zhou et al.   HEPATOLOGY

Mincle Signaling Promotes Con A Hepatitis

(2016) Stephanie H. Greco et al.   JOURNAL OF IMMUNOLOGY

The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing

(2016) Rachel Stegeman et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

(2016) Constantin Cretu et al.   MOLECULAR CELL

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

(2016) R. Rauhut et al.   SCIENCE

Structure of a yeast activated spliceosome at 3.5 A resolution

(2016) C. Yan et al.   SCIENCE

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

(2016) Samar Alsafadi et al.   Nature Communications

Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis

(2016) Felipe Marques et al.   PLoS Genetics

Mincle Signaling in the Innate Immune Response after Traumatic Brain Injury

(2015) Juan Carlos de Rivero Vaccari et al.   JOURNAL OF NEUROTRAUMA

Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC)

(2015) Weijin Xu et al.   MEDICAL ONCOLOGY

Dramatically reduced spliceosome inCyanidioschyzon merolae

(2015) Martha R. Stark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats

(2015) Yue He et al.   STROKE

PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145

(2015) Yanzhong Yang et al.   Nature Communications

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

(2015) Rachel B. Darman et al.   Cell Reports

SF3B1 Association with Chromatin Determines Splicing Outcomes

(2015) Nir Kfir et al.   Cell Reports

Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers

(2015) Christopher DeBoever et al.   PLoS Computational Biology

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses

(2015) Claire A. Schreiber et al.   PLoS Pathogens

Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma

(2015) Yung-Hao Wong et al.   Biomed Research International

Rodriguez syndrome withSF3B4mutation: A severe form of Nager syndrome?

(2014) Elizabeth McPherson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Screening of cellular proteins that interact with the classical swine fever virus non-structural protein 5A by yeast two-hybrid analysis

(2014) Chengcheng Zhang et al.   JOURNAL OF BIOSCIENCES

Sudemycin E influences alternative splicing and changes chromatin modifications

(2014) Paolo Convertini et al.   NUCLEIC ACIDS RESEARCH

Splicing factor mutations and cancer

(2014) Kenichi Yoshida et al.   Wiley Interdisciplinary Reviews-RNA

Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system

(2013) J.-B. Fourmann et al.   GENES & DEVELOPMENT

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

(2013) C. G. Hubert et al.   GENES & DEVELOPMENT

Rearrangements within human spliceosomes captured after exon ligation

(2013) J. O. Ilagan et al.   RNA

Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130)

(2013) L. Cordero-Espinoza et al.   Biology Open

Haploinsufficiency of SF3B4, a Component of the Pre-mRNA Spliceosomal Complex, Causes Nager Syndrome

(2012) Francois P. Bernier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

(2012) Johnny M. Tkach et al.   NATURE CELL BIOLOGY

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

(2011) Akira Yokoi et al.   FEBS Journal

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

(2011) E. G. Folco et al.   GENES & DEVELOPMENT

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

(2010) R. M. Lardelli et al.   RNA

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

(2009) Zbigniew Warkocki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome

(2008) Suchithra Menon et al.   BMC BIOCHEMISTRY

Nuclear Inhibitor of Protein Phosphatase-1 (NIPP1) Directs Protein Phosphatase-1 (PP1) to Dephosphorylate the U2 Small Nuclear Ribonucleoprotein Particle (snRNP) Component, Spliceosome-associated Protein 155 (Sap155)

(2008) Nobuhiro Tanuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY