Multi-walled carbon nanotubes trigger lysosome-dependent cell death (pyroptosis) in macrophages but not in neutrophils

Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation

(2021) Satoshi Omori et al.   Cell Reports

Grouping all carbon nanotubes into a single substance category is scientifically unjustified

(2020) Bengt Fadeel et al.   Nature Nanotechnology

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Banning carbon nanotubes would be scientifically unjustified and damaging to innovation

(2020) Daniel A. Heller et al.   Nature Nanotechnology

Cytotoxicity profiles of multi-walled carbon nanotubes with different physico-chemical properties

(2020) Katsuhide Fujita et al.   TOXICOLOGY MECHANISMS AND METHODS

Carbon Nanotubes Interference with Luminescence-Based Assays

(2020) Tomasz Szymański et al.   Materials

Neutrophil activation by nanomaterials in vitro: comparing strengths and limitations of primary human cells with those of an immortalized (HL-60) cell line

(2020) Rachel Verdon et al.   Nanotoxicology

Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities

(2020) Kelly Fraser et al.   Particle and Fibre Toxicology

Multi-walled carbon nanotubes induce stronger migration of inflammatory cells in vitro than asbestos or granular particles but a similar pattern of inflammatory mediators

(2019) A. Westphal Götz et al.   TOXICOLOGY IN VITRO

The toxicity of multi-walled carbon nanotubes (MWCNTs) to human endothelial cells: The influence of diameters of MWCNTs

(2019) Xuqi Zhao et al.   FOOD AND CHEMICAL TOXICOLOGY

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Cellular Toxicity and Immunological Effects of Carbon-based Nanomaterials

(2019) Xia Yuan et al.   Particle and Fibre Toxicology

Nano-bio interactions: a neutrophil-centric view

(2019) Sandeep Keshavan et al.   Cell Death & Disease

Comparative in Vitro Cytotoxicity of Realistic Doses of Benchmark Multi-Walled Carbon Nanotubes towards Macrophages and Airway Epithelial Cells

(2019) Di Cristo et al.   Nanomaterials

Distinct autophagy-apoptosis related pathways activated by Multi-walled (NM 400) and Single-walled carbon nanotubes (NIST-SRM2483) in human bronchial epithelial (16HBE14o-) cells

(2019) Manosij Ghosh et al.   JOURNAL OF HAZARDOUS MATERIALS

Carbon nanotubes, but not spherical nanoparticles, block autophagy by a shape-related targeting of lysosomes in murine macrophages

(2018) Vanessa Cohignac et al.   Autophagy

Similarities and differences in surface receptor expression by THP-1 monocytes and differentiated macrophages polarized using seven different conditioning regimens

(2018) Megan A. Forrester et al.   CELLULAR IMMUNOLOGY

Quantitation of cell-associated carbon nanotubes: selective binding and accumulation of carboxylated carbon nanotubes by macrophages

(2018) Ruhung Wang et al.   Nanotoxicology

PEGylation of model drug carriers enhances phagocytosis by primary human neutrophils

(2018) William J. Kelley et al.   Acta Biomaterialia

Adsorption of Plasma Proteins on Single-Walled Carbon Nanotubes Reduced Cytotoxicity and Modulated Neutrophil Activation

(2018) Naihao Lu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Lysosomal membrane permeabilization and cell death

(2018) Fengjuan Wang et al.   TRAFFIC

Carbon Nanotubes and Related Nanomaterials: Critical Advances and Challenges for Synthesis toward Mainstream Commercial Applications

(2018) Rahul Rao et al.   ACS Nano

Threshold Rigidity Values for the Asbestos-like Pathogenicity of High-Aspect-Ratio Carbon Nanotubes in a Mouse Pleural Inflammation Model

(2018) Dong-Keun Lee et al.   ACS Nano

Nanomaterial Interactions with Human Neutrophils

(2018) Paul W. Bisso et al.   ACS Biomaterials-Science & Engineering

Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis

(2017) Luna Rahman et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes

(2017) Katherine S. Duke et al.   Particle and Fibre Toxicology

Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity

(2017) Forrest Jessop et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cytokine Profiling of Primary Human Macrophages Exposed to Endotoxin-Free Graphene Oxide: Size-Independent NLRP3 Inflammasome Activation

(2017) Sourav P. Mukherjee et al.   Advanced Healthcare Materials

Neutrophils at the Biological–Material Interface

(2017) Siddharth Jhunjhunwala   ACS Biomaterials-Science & Engineering

Neutrophils at the Biological–Material Interface

(2017) Siddharth Jhunjhunwala   ACS Biomaterials Science & Engineering

The impact of multi-walled carbon nanotubes with different amount of metallic impurities on immunometabolic parameters in healthy volunteers

(2016) T.I. Vitkina et al.   FOOD AND CHEMICAL TOXICOLOGY

Biological interactions of carbon-based nanomaterials: From coronation to degradation

(2016) Kunal Bhattacharya et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles

(2016) Wenpeng Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The JRC Nanomaterials Repository: A unique facility providing representative test materials for nanoEHS research

(2016) Sara Totaro et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluation of the cytotoxic and genotoxic effects of benchmark multi-walled carbon nanotubes in relation to their physicochemical properties

(2016) Henriqueta Louro et al.   TOXICOLOGY LETTERS

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

(2015) Jürgen Brojatsch et al.   CELL CYCLE

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Asbestos and multi-walled carbon nanotubes generate distinct oxidative responses in inflammatory cells

(2015) Satomi Funahashi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

(2015) Matthew S.P. Boyles et al.   TOXICOLOGY IN VITRO

Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy

(2015) Lucian Farcal et al.   PLoS One

Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry

(2014) Ling Wu et al.   ACS Nano

Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line

(2014) Petra Jackson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes

(2014) Yann Grosse et al.   LANCET ONCOLOGY

Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammationin vivo

(2014) Forrest Jessop et al.   Nanotoxicology

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

(2014) Salik Hussain et al.   Particle and Fibre Toxicology

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

(2014) Elina M Rydman et al.   Particle and Fibre Toxicology

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

Pulmonary toxicity of carbon nanotubes and asbestos — Similarities and differences

(2013) Ken Donaldson et al.   ADVANCED DRUG DELIVERY REVIEWS

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

(2013) Heriberto Lima Jr. et al.   CELL CYCLE

The Role of Iron Impurities in the Toxic Effects Exerted by Short Multiwalled Carbon Nanotubes (MWCNT) in Murine Alveolar Macrophages

(2013) E. Aldieri et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model

(2013) Tina M. Sager et al.   Nanotoxicology

Effect of MWCNT size, carboxylation, and purification on in vitro and in vivo toxicity, inflammation and lung pathology

(2013) Raymond F Hamilton et al.   Particle and Fibre Toxicology

Carbon Nanotubes: Present and Future Commercial Applications

(2013) M. F. L. De Volder et al.   SCIENCE

Functionalization of Carbon Nanoparticles Modulates Inflammatory Cell Recruitment and NLRP3 Inflammasome Activation

(2013) Marie Yang et al.   Small

Occupational Nanosafety Considerations for Carbon Nanotubes and Carbon Nanofibers

(2012) Vincent Castranova et al.   ACCOUNTS OF CHEMICAL RESEARCH

Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials

(2012) Fernando Torres Andón et al.   ACCOUNTS OF CHEMICAL RESEARCH

Understanding the Toxicity of Carbon Nanotubes

(2012) Ying Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Adsorption of Surfactant Lipids by Single-Walled Carbon Nanotubes in Mouse Lung upon Pharyngeal Aspiration

(2012) Alexander A. Kapralov et al.   ACS Nano

Autophagy in Toxicology: Cause or Consequence?

(2012) Sten Orrenius et al.   Annual Review of Pharmacology and Toxicology

Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress

(2012) Anna A. Shvedova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity

(2011) Ningning Gao et al.   ACS Nano

Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles

(2011) Anna C. Reisetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

(2011) H. Nagai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells

(2011) Andrea Kunzmann et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling

(2011) H-L Liu et al.   Cell Death & Disease

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

(2010) Valerian E. Kagan et al.   Nature Nanotechnology

Uptake of Noncytotoxic Acid-Treated Single-Walled Carbon Nanotubes into the Cytoplasm of Human Macrophage Cells

(2009) Alexandra E. Porter et al.   ACS Nano

Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells

(2009) Crystal Cheng et al.   BIOMATERIALS

Efficient internalization of mesoporous silica particles of different sizes by primary human macrophages without impairment of macrophage clearance of apoptotic or antibody-opsonized target cells

(2009) Erika Witasp et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: role in macrophage recognition and engulfment

(2008) Siriporn Jitkaew et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line

(2008) N.A. Monteiro-Riviere et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY