Cellular Toxicity and Immunological Effects of Carbon-based Nanomaterials

A review of toxicity studies of single-walled carbon nanotubes in laboratory animals

(2016) Makoto Ema et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Carbon Nanotubes Activate Macrophages into a M1/M2 Mixed Status: Recruiting Naïve Macrophages and Supporting Angiogenesis

(2015) Jie Meng et al.   ACS Applied Materials & Interfaces

Size effects of single-walled carbon nanotubes onin vivoandin vitropulmonary toxicity

(2015) Katsuhide Fujita et al.   INHALATION TOXICOLOGY

Functional consequences for primary human alveolar macrophages following treatment with long, but not short, multiwalled carbon nanotubes

(2015) Terry Tetley et al.   International Journal of Nanomedicine

Comparison of cellular toxicity between multi-walled carbon nanotubes and onion-like shell-shaped carbon nanoparticles

(2015) Seunghyon Kang et al.   JOURNAL OF NANOPARTICLE RESEARCH

Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model

(2015) Matthias Kroker et al.   Particle and Fibre Toxicology

No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice

(2015) Shanze Chen et al.   Particle and Fibre Toxicology

A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor

(2015) Elina M. Rydman et al.   TOXICOLOGICAL SCIENCES

MyD88 mediates in vivo effector functions of alveolar macrophages in acute lung inflammatory responses to carbon nanotube exposure

(2015) Evan A. Frank et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

(2015) Matthew S.P. Boyles et al.   TOXICOLOGY IN VITRO

In vitro toxicity of carbon nanotubes, nano-graphite and carbon black, similar impacts of acid functionalization

(2015) Agathe Figarol et al.   TOXICOLOGY IN VITRO

Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes

(2014) Jie Dong et al.   ARCHIVES OF TOXICOLOGY

Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung

(2014) D. van Berlo et al.   ARCHIVES OF TOXICOLOGY

Impact of carbon nanotubes and graphene on immune cells

(2014) Marco Orecchioni et al.   Journal of Translational Medicine

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

(2014) Elina M Rydman et al.   Particle and Fibre Toxicology

Lysosomal membrane permeabilization: Carbon nanohorn-induced reactive oxygen species generation and toxicity by this neglected mechanism

(2014) Mei Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toxic response of HIPCO single-walled carbon nanotubes in mice and RAW264.7 macrophage cells

(2014) Eun-Jung Park et al.   TOXICOLOGY LETTERS

Single-Walled Carbon Nanotube Surface Control of Complement Recognition and Activation

(2013) Alina J. Andersen et al.   ACS Nano

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

When carbon nanotubes encounter the immune system: Desirable and undesirable effects

(2013) Hélène Dumortier   ADVANCED DRUG DELIVERY REVIEWS

Exposure to multi-walled carbon nanotubes results in aggravation of airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in a mouse model of asthma

(2013) Carole Ronzani et al.   ARCHIVES OF TOXICOLOGY

Carbon black vs. black carbon and other airborne materials containing elemental carbon: Physical and chemical distinctions

(2013) Christopher M. Long et al.   ENVIRONMENTAL POLLUTION

Complement activation by PEG-functionalized multi-walled carbon nanotubes is independent of PEG molecular mass and surface density

(2013) Alina J. Andersen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model

(2013) Tina M. Sager et al.   Nanotoxicology

Correction: Removal of Pharmaceutical Residues by Ferrate(VI)

(2013) JiaQian Jiang et al.   PLoS One

Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase

(2013) Fernando T. Andón et al.   Small

Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages

(2013) Bin Wan et al.   TOXICOLOGY LETTERS

Perspectives on carbon nanotube-mediated adverse immune effects

(2012) Alina J. Andersen et al.   ADVANCED DRUG DELIVERY REVIEWS

NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination

(2012) Raymond F. Hamilton et al.   INHALATION TOXICOLOGY

Comparison of cytotoxic and inflammatory responses of pristine and functionalized multi-walled carbon nanotubes in RAW 264.7 mouse macrophages

(2012) Ting Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

The Interaction of Serum Proteins with Carbon Nanotubes Depend on the Physicochemical Properties of Nanotubes

(2012) Jiangfeng Du et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Water-Soluble Taurine-Functionalized Multi-Walled Carbon Nanotubes Induce Less Damage to Mitochondria of RAW 264.7 Cells

(2012) Tian Chen et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages

(2012) Ping-Xuan Dong et al.   Nanotoxicology

IL-1R signalling is critical for regulation of multi-walled carbon nanotubes-induced acute lung inflammation in C57Bl/6 mice

(2012) Teri Alyn Girtsman et al.   Nanotoxicology

Cytotoxicity of functionalized carbon nanotubes in J774A macrophages

(2012) Silvia Lorena Montes-Fonseca et al.   New Biotechnology

Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver

(2012) Julie A Bourdon et al.   Particle and Fibre Toxicology

The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells

(2012) Fiona A Murphy et al.   Particle and Fibre Toxicology

Impaired Clearance and Enhanced Pulmonary Inflammatory/Fibrotic Response to Carbon Nanotubes in Myeloperoxidase-Deficient Mice

(2012) Anna A. Shvedova et al.   PLoS One

Multi-walled carbon nanotubes induce apoptosis via mitochondrial pathway and scavenger receptor

(2012) Xiang Wang et al.   TOXICOLOGY IN VITRO

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Proteins of the Innate Immune System Crystallize on Carbon Nanotubes but Are Not Activated

(2011) Wai Li Ling et al.   ACS Nano

Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models

(2011) Dania Movia et al.   ACS Nano

Single-Walled Carbon Nanotubes Induce Airway Hyperreactivity and Parenchymal Injury in Mice

(2011) Wan-Yu Hsieh et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective

(2011) S.M. Moghimi et al.   Annual Review of Pharmacology and Toxicology

PEG-Modified Carbon Nanotubes in Biomedicine: Current Status and Challenges Ahead

(2011) Massimo Bottini et al.   BIOMACROMOLECULES

Intracellular dynamics of cationic and anionic polystyrene nanoparticles without direct interaction with mitotic spindle and chromosomes

(2011) Yuexian Liu et al.   BIOMATERIALS

The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways

(2011) Yang Li et al.   BIOMATERIALS

Lysosomal membrane destabilization induced by high accumulation of single-walled carbon nanohorns in murine macrophage RAW 264.7

(2011) Yoshio Tahara et al.   BIOMATERIALS

Thickness of Multiwalled Carbon Nanotubes Affects Their Lung Toxicity

(2011) Ivana Fenoglio et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pulmonary and systemic responses of highly pure and well-dispersed single-wall carbon nanotubes after intratracheal instillation in rats

(2011) Norihiro Kobayashi et al.   INHALATION TOXICOLOGY

Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles

(2011) Anna C. Reisetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast Cells as Sensors of Cell Injury through IL-33 Recognition

(2011) M. Enoksson et al.   JOURNAL OF IMMUNOLOGY

Identification of Systemic Markers from A Pulmonary Carbon Nanotube Exposure

(2011) Aaron Erdely et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Ex vivo impact of functionalized carbon nanotubes on human immune cells

(2011) Lucia Gemma Delogu et al.   Nanomedicine

Up-regulation of T lymphocyte and antibody production by inflammatory cytokines released by macrophage exposure to multi-walled carbon nanotubes

(2011) Ana Carolina P Grecco et al.   NANOTECHNOLOGY

Pulmonary toxicity of well-dispersed multi-wall carbon nanotubes following inhalation and intratracheal instillation

(2011) Yasuo Morimoto et al.   Nanotoxicology

Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes

(2011) Cuicui Ge et al.   Nanotoxicology

Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

(2011) Robert R Mercer et al.   Particle and Fibre Toxicology

Multi-Walled Carbon Nanotube Instillation Impairs Pulmonary Function in C57BL/6 Mice

(2011) Xiaojia Wang et al.   Particle and Fibre Toxicology

Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes In Vitro

(2011) Zhao Sun et al.   PLoS One

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of carboxylic acid functionalization on the cytotoxic effects induced by single wall carbon nanotubes on human endothelial cells (HUVEC)

(2011) Daniel Gutiérrez-Praena et al.   TOXICOLOGY IN VITRO

Human myeloperoxidase in innate and acquired immunity

(2010) Juergen Arnhold et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biocompatibility of polymer grafted core/shell iron/carbon nanoparticles

(2010) Qingxin Mu et al.   BIOMATERIALS

Multi-walled carbon nanotubes conjugated to tumor protein enhance the uptake of tumor antigens by human dendritic cells in vitro

(2010) Zhao Sun et al.   CELL RESEARCH

Carbohydrate functionalized carbon nanotubes and their applications

(2010) Bala Kishan Gorityala et al.   CHEMICAL SOCIETY REVIEWS

Review of carbon nanotubes toxicity and exposure—Appraisal of human health risk assessment based on open literature

(2010) Karin Aschberger et al.   CRITICAL REVIEWS IN TOXICOLOGY

Pulmonary Toxicity in Mice Exposed to Low and Medium Doses of Water-Soluble Multi-Walled Carbon Nanotubes

(2010) X. Wang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Single-walled carbon nanohorns and their applications

(2010) Shuyun Zhu et al.   Nanoscale

Oxidative biodegradation of single- and multi-walled carbon nanotubes

(2010) Julie Russier et al.   Nanoscale

The era of carbon allotropes

(2010) Andreas Hirsch   NATURE MATERIALS

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

(2010) Valerian E. Kagan et al.   Nature Nanotechnology

Nanomaterial cytotoxicity is composition, size, and cell type dependent

(2010) Syed K Sohaebuddin et al.   Particle and Fibre Toxicology

Uptake of Noncytotoxic Acid-Treated Single-Walled Carbon Nanotubes into the Cytoplasm of Human Macrophage Cells

(2009) Alexandra E. Porter et al.   ACS Nano

Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes

(2009) Mark F. Cesta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Janeway's Immunobiology, 7th Edition by Kenneth Murphy, Paul Travers, and Mark Walport

(2009) Poonam Gulati   BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells

(2009) Crystal Cheng et al.   BIOMATERIALS

Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses

(2009) Erika Witasp et al.   INHALATION TOXICOLOGY

Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs

(2009) PARESH CHANDRA RAY et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Mechanistic Investigations of Horseradish Peroxidase-Catalyzed Degradation of Single-Walled Carbon Nanotubes

(2009) Brett L. Allen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice

(2009) L. A. Mitchell et al.   Nature Nanotechnology

Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo

(2009) Nagarjun V. Konduru et al.   PLoS One

Single-Walled and Multi-Walled Carbon Nanotubes Promote Allergic Immune Responses in Mice

(2009) Unni C. Nygaard et al.   TOXICOLOGICAL SCIENCES

Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation

(2009) Eun-Jung Park et al.   TOXICOLOGY

Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells

(2009) J. Palomäki et al.   TOXICOLOGY

Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samples

(2009) Eva Herzog et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model

(2009) Ken-ichiro Inoue et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quantitative Analysis of Metal Impurities in Carbon Nanotubes: Efficacy of Different Pretreatment Protocols for ICPMS Spectroscopy

(2008) Cuicui Ge et al.   ANALYTICAL CHEMISTRY

Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications

(2008) Michael J. Davies et al.   ANTIOXIDANTS & REDOX SIGNALING

Raw Single-Wall Carbon Nanotubes Induce Oxidative Stress and Activate MAPKs, AP-1, NF-κB, and Akt in Normal and Malignant Human Mesothelial Cells

(2008) Maricica Pacurari et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Complement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnover

(2008) Islam Hamad et al.   MOLECULAR IMMUNOLOGY

Biodegradation of Single-Walled Carbon Nanotubes through Enzymatic Catalysis

(2008) Brett L. Allen et al.   NANO LETTERS

Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers

(2008) Aaron Erdely et al.   NANO LETTERS

Are carbon nanotubes safe?

(2008) Yuliang Zhao et al.   Nature Nanotechnology

Carbon nanotubes as photoacoustic molecular imaging agents in living mice

(2008) Adam De La Zerda et al.   Nature Nanotechnology

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice

(2008) Sheng-Tao Yang et al.   TOXICOLOGY LETTERS

Silica binding and toxicity in alveolar macrophages

(2007) Raymond F. Hamilton et al.   FREE RADICAL BIOLOGY AND MEDICINE