Cytokine Profiling of Primary Human Macrophages Exposed to Endotoxin-Free Graphene Oxide: Size-Independent NLRP3 Inflammasome Activation

The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research

(2017) Xiaoyuan Miao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Graphene and the Immune System: A Romance of Many Dimensions

(2017) Sourav P. Mukherjee et al.   Frontiers in Immunology

Graphene-Induced Pore Formation on Cell Membranes

(2017) Guangxin Duan et al.   Scientific Reports

Assessing the Immunosafety of Engineered Nanoparticles with a Novel in Vitro Model Based on Human Primary Monocytes

(2016) Yang Li et al.   ACS Applied Materials & Interfaces

Spontaneous Protein Adsorption on Graphene Oxide Nanosheets Allowing Efficient Intracellular Vaccine Protein Delivery

(2016) Hui Li et al.   ACS Applied Materials & Interfaces

Identification and Optimization of Carbon Radicals on Hydrated Graphene Oxide for Ubiquitous Antibacterial Coatings

(2016) Ruibin Li et al.   ACS Nano

Selective Accelerated Proliferation of Malignant Breast Cancer Cells on Planar Graphene Oxide Films

(2016) Kenry et al.   ACS Nano

Graphene Oxides Decorated with Carnosine as an Adjuvant To Modulate Innate Immune and Improve Adaptive Immunity in Vivo

(2016) Chunchun Meng et al.   ACS Nano

Carboxyl- and amino-functionalized polystyrene nanoparticles differentially affect the polarization profile of M1 and M2 macrophage subsets

(2016) Ann-Kathrin Fuchs et al.   BIOMATERIALS

Endotoxin contamination: a key element in the interpretation of nanosafety studies

(2016) Yang Li et al.   Nanomedicine

Biological interactions of carbon-based nanomaterials: From coronation to degradation

(2016) Kunal Bhattacharya et al.   Nanomedicine-Nanotechnology Biology and Medicine

Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity

(2016) Ligeng Xu et al.   Nanoscale

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Detection of Endotoxin Contamination of Graphene Based Materials Using the TNF-α Expression Test and Guidelines for Endotoxin-Free Graphene Oxide Production

(2016) Sourav P. Mukherjee et al.   PLoS One

Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles

(2016) Wenpeng Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127

(2016) Young Chol Cho et al.   Scientific Reports

Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells

(2016) Abderrahim Naji et al.   Scientific Reports

Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress

(2016) Sandeep Mittal et al.   Scientific Reports

Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals

(2015) Juan Ma et al.   ACS Nano

Graphene Induces Formation of Pores That Kill Spherical and Rod-Shaped Bacteria

(2015) Vy T. H. Pham et al.   ACS Nano

Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

(2015) Xiang Wang et al.   ACS Nano

In Vivo Compatibility of Graphene Oxide with Differing Oxidation States

(2015) Stefanie A. Sydlik et al.   ACS Nano

It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

(2015) Consol Farrera et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems

(2015) Andrea C. Ferrari et al.   Nanoscale

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Molecular and Genomic Impact of Large and Small Lateral Dimension Graphene Oxide Sheets on Human Immune Cells from Healthy Donors

(2015) Marco Orecchioni et al.   Advanced Healthcare Materials

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

A secretomics analysis reveals major differences in the macrophage responses towards different types of carbon nanotubes

(2014) Jaana Palomäki et al.   Nanotoxicology

Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammationin vivo

(2014) Forrest Jessop et al.   Nanotoxicology

Dysregulation of Macrophage Activation Profiles by Engineered Nanoparticles

(2013) Vamsi Kodali et al.   ACS Nano

Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages

(2013) Guangbo Qu et al.   ACS Nano

Mechanisms of carbon nanotube-induced toxicity: Focus on pulmonary inflammation

(2013) Kunal Bhattacharya et al.   ADVANCED DRUG DELIVERY REVIEWS

Prospects and Challenges of Graphene in Biomedical Applications

(2013) Dimitrios Bitounis et al.   ADVANCED MATERIALS

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

(2013) Stephen W. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells

(2013) Julie Russier et al.   Nanoscale

Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets

(2013) Yusong Tu et al.   Nature Nanotechnology

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Hemocompatibility and Macrophage Response of Pristine and Functionalized Graphene

(2012) Abhilash Sasidharan et al.   Small

Purified Graphene Oxide Dispersions Lack In Vitro Cytotoxicity and In Vivo Pathogenicity

(2012) Hanene Ali-Boucetta et al.   Advanced Healthcare Materials

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Graphene Oxide: A Nonspecific Enhancer of Cellular Growth

(2011) Oscar N. Ruiz et al.   ACS Nano

Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers

(2011) Neus Feliu et al.   BIOMATERIALS

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

(2011) John B. Mumm et al.   CANCER CELL

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

(2011) H. Nagai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells

(2011) Andrea Kunzmann et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Th1 life cycle: molecular control of IFN-γ to IL-10 switching

(2011) Andrew Cope et al.   TRENDS IN IMMUNOLOGY

Graphene Oxide Sheets at Interfaces

(2010) Jaemyung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Wettability and Surface Free Energy of Graphene Films

(2009) Shiren Wang et al.   LANGMUIR

Efficient internalization of mesoporous silica particles of different sizes by primary human macrophages without impairment of macrophage clearance of apoptotic or antibody-opsonized target cells

(2009) Erika Witasp et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE