Nano-bio interactions: a neutrophil-centric view

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

(2019) Kristopher R. Genschmer et al.   CELL

Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death

(2019) Marzena Szwed et al.   Nanotoxicology

Nanoparticles and danger signals: Oral delivery vehicles as potential disruptors of intestinal barrier homeostasis

(2019) Alexandra A. Vita et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human primary macrophages scavenge AuNPs and eliminate it through exosomes. A natural shuttling for nanomaterials

(2019) Mariantonia Logozzi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The viral protein corona directs viral pathogenesis and amyloid aggregation

(2019) Kariem Ezzat et al.   Nature Communications

Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes

(2018) Vahid Mirshafiee et al.   ACS Nano

Single layer and few layer graphene are degraded by neutrophil myeloperoxidase

(2018) Rajendra Kurapati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona

(2018) Manuel Tonigold et al.   Nature Nanotechnology

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nanomaterial exposure and sterile inflammatory reactions

(2018) Veruscka Leso et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Necroptosis and neutrophil-associated disorders

(2018) Xiaoliang Wang et al.   Cell Death & Disease

Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages

(2018) Bing He et al.   Nature Communications

Structural absorption by barbule microstructures of super black bird of paradise feathers

(2018) Dakota E. McCoy et al.   Nature Communications

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations

(2018) Jennifer A. Fraser et al.   Scientific Reports

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Identification of Exosomal miRNAs in Rats With Pulmonary Neutrophilic Inflammation Induced by Zinc Oxide Nanoparticles

(2018) Yamei Qiao et al.   Frontiers in Physiology

Graphene Oxide Elicits Membrane Lipid Changes and Neutrophil Extracellular Trap Formation

(2018) Sourav P. Mukherjee et al.   Chem

PEGylation of model drug carriers enhances phagocytosis by primary human neutrophils

(2018) William J. Kelley et al.   Acta Biomaterialia

Adsorption of Plasma Proteins on Single-Walled Carbon Nanotubes Reduced Cytotoxicity and Modulated Neutrophil Activation

(2018) Naihao Lu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

(2018) Raimunda S. S. Azevedo et al.   Scientific Reports

Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

(2018) Bengt Fadeel et al.   ACS Nano

Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes

(2018) Koumei Shirasuna et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A scavenging system against internal pathogens promoted by the circulating protein apoptosis inhibitor of macrophage (AIM)

(2018) Satoko Arai et al.   Seminars in Immunopathology

Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

(2018) Huiyi Liang et al.   Nature Communications

Nanomaterial Interactions with Human Neutrophils

(2018) Paul W. Bisso et al.   ACS Biomaterials-Science & Engineering

Inert Coats of Magnetic Nanoparticles Prevent Formation of Occlusive Intravascular Co-aggregates With Neutrophil Extracellular Traps

(2018) Rostyslav Bilyy et al.   Frontiers in Immunology

Effect of removing Kupffer cells on nanoparticle tumor delivery

(2017) Anthony J. Tavares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis

(2017) Adrian Schreiber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation

(2017) Ana Luísa Silva et al.   SEMINARS IN IMMUNOLOGY

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

(2017) Francesco Barbero et al.   SEMINARS IN IMMUNOLOGY

Nanoparticles and innate immunity: new perspectives on host defence

(2017) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells

(2017) Jun Zhang et al.   Cell Death & Disease

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Graphene and the Immune System: A Romance of Many Dimensions

(2017) Sourav P. Mukherjee et al.   Frontiers in Immunology

Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity

(2017) J. Stephen et al.   npj Vaccines

Graphene oxide is degraded by neutrophils and the degradation products are non-genotoxic

(2017) Sourav P. Mukherjee et al.   Nanoscale

Differential Signalling and Kinetics of Neutrophil Extracellular Trap Release Revealed by Quantitative Live Imaging

(2017) Maarten van der Linden et al.   Scientific Reports

Biocompatibility Assessment of Detonation Nanodiamond in Non-Human Primates and Rats Using Histological, Hematologic, and Urine Analysis

(2016) Laura Moore et al.   ACS Nano

Biological interactions of carbon-based nanomaterials: From coronation to degradation

(2016) Kunal Bhattacharya et al.   Nanomedicine-Nanotechnology Biology and Medicine

Adsorbed plasma proteins modulate the effects of single-walled carbon nanotubes on neutrophils in blood

(2016) Irina I. Vlasova et al.   Nanomedicine-Nanotechnology Biology and Medicine

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

(2016) Luis E. Muñoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scavenging nucleic acid debris to combat autoimmunity and infectious disease

(2016) Eda K. Holl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications

(2016) Irina I. Vlasova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils

(2016) Claudie Noël et al.   TOXICOLOGY IN VITRO

In Vivo Compatibility of Graphene Oxide with Differing Oxidation States

(2015) Stefanie A. Sydlik et al.   ACS Nano

Inflammasome-Independent Regulation of IL-1-Family Cytokines

(2015) Mihai G. Netea et al.   Annual Review of Immunology

Nanoparticles enhance the ability of human neutrophils to exert phagocytosis by a Syk-dependent mechanism

(2015) K. Babin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The impact of cationic solid lipid nanoparticles on human neutrophil activation and formation of neutrophil extracellular traps (NETs)

(2015) Tsong-Long Hwang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

(2015) Consol Farrera et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Harnessing nanoparticles for immune modulation

(2015) Daniel R. Getts et al.   TRENDS IN IMMUNOLOGY

Lung Macrophages “Digest” Carbon Nanotubes Using a Superoxide/Peroxynitrite Oxidative Pathway

(2014) Valerian E. Kagan et al.   ACS Nano

Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps

(2014) Ariane Neumann et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Localization and Functionality of the Inflammasome in Neutrophils

(2014) Martina Bakele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular entrapment and degradation of single-walled carbon nanotubes

(2014) Consol Farrera et al.   Nanoscale

Immunotoxicity of nanoparticles: a computational study suggests that CNTs and C60 fullerenes might be recognized as pathogens by Toll-like receptors

(2014) M. Turabekova et al.   Nanoscale

Enzymatic ‘stripping’ and degradation of PEGylated carbon nanotubes

(2014) Kunal Bhattacharya et al.   Nanoscale

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes

(2014) Sudjit Luanpitpong et al.   Particle and Fibre Toxicology

Zinc oxide nanoparticles delay human neutrophil apoptosis by a de novo protein synthesis-dependent and reactive oxygen species-independent mechanism

(2014) David M. Goncalves et al.   TOXICOLOGY IN VITRO

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

Mechanisms of carbon nanotube-induced toxicity: Focus on pulmonary inflammation

(2013) Kunal Bhattacharya et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular modeling in structural nano-toxicology: Interactions of nano-particles with nano-machinery of cells

(2013) Naveena Yanamala et al.   ADVANCED DRUG DELIVERY REVIEWS

Evidence That Polyhydroxylated C60 Fullerenes (Fullerenols) Amplify the Effect of Lipopolysaccharides to Induce Rapid Leukocyte Infiltration in Vivo

(2013) D. M. Gonçalves et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

(2013) Stephen W. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Carbon Nanotubes: Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase (Small 16/2013)

(2013) Fernando T. Andón et al.   Small

TiO2, CeO2 and ZnO nanoparticles and modulation of the degranulation process in human neutrophils

(2013) Kim Babin et al.   TOXICOLOGY LETTERS

Pattern recognition receptor function in neutrophils

(2013) Christina J. Thomas et al.   TRENDS IN IMMUNOLOGY

Confocal Raman Imaging Study Showing Macrophage Mediated Biodegradation of Graphene In Vivo

(2013) Chundayil Madathil Girish et al.   Advanced Healthcare Materials

The Dendritic Cell Response to Classic, Emerging, and Homeostatic Danger Signals. Implications for Autoimmunity

(2013) Paul M. Gallo et al.   Frontiers in Immunology

Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials

(2012) Fernando Torres Andón et al.   ACCOUNTS OF CHEMICAL RESEARCH

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

(2012) S. J. Klebanoff et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Chemical Approach for Cell-Specific Targeting of Nanomaterials: Small-Molecule-Initiated Misfolding of Nanoparticle Corona Proteins

(2012) Kanlaya Prapainop et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Impaired Clearance and Enhanced Pulmonary Inflammatory/Fibrotic Response to Carbon Nanotubes in Myeloperoxidase-Deficient Mice

(2012) Anna A. Shvedova et al.   PLoS One

NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

(2012) Bingbing Sun et al.   Small

Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress

(2012) Anna A. Shvedova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Nucleic acid-binding polymers as anti-inflammatory agents

(2011) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes as Extrapulmonary Signaling Conveyors for Nanoparticle-Induced Systemic Immune Activation

(2011) Motao Zhu et al.   Small

Particle size and activation threshold: a new dimension of danger signaling

(2010) L. Rettig et al.   BLOOD

Metal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung: Important Implications for Nanoparticle Testing

(2010) Wan-Seob Cho et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Review: Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation

(2010) Michael L. Litvack et al.   Innate Immunity

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

(2010) Valerian E. Kagan et al.   Nature Nanotechnology

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells

(2010) Salik Hussain et al.   Particle and Fibre Toxicology

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Phagocytosis Independent Extracellular Nanoparticle Clearance by Human Immune Cells

(2009) Matthias Bartneck et al.   NANO LETTERS

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Activation of human neutrophils by titanium dioxide (TiO2) nanoparticles

(2009) D.M. Gonçalves et al.   TOXICOLOGY IN VITRO

The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse

(2008) Rebecca C. Furze et al.   FASEB JOURNAL

Protein Binding by Functionalized Multiwalled Carbon Nanotubes Is Governed by the Surface Chemistry of Both Parties and the Nanotube Diameter

(2008) Qingxin Mu et al.   Journal of Physical Chemistry C

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE