Astaxanthin as a Modulator of Nrf2, NF-κB, and Their Crosstalk: Molecular Mechanisms and Possible Clinical Applications

Carotenoids and Cognitive Outcomes: A Meta-Analysis of Randomized Intervention Trials

(2021) Sergio Davinelli et al.   Antioxidants

Nrf2 a molecular therapeutic target for Astaxanthin

(2021) Zeynab Kohandel et al.   BIOMEDICINE & PHARMACOTHERAPY

“Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials”

(2021) Andrea Donoso et al.   PHARMACOLOGICAL RESEARCH

Astaxanthin protects against early acute kidney injury in severely burned rats by inactivating the TLR4/MyD88/NF-κB axis and upregulating heme oxygenase-1

(2021) Songxue Guo et al.   Scientific Reports

The Role of Astaxanthin on Chronic Diseases

(2021) Xueqi Zhang et al.   Crystals

Effects of Flavonoid Supplementation on Common Eye Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

(2021) Sergio Davinelli et al.   Frontiers in Nutrition

Dietary astaxanthin: an excellent carotenoid with multiple health benefits

(2021) Yunrui Cao et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Astaxanthin alleviates neuropathic pain by inhibiting the MAPKs and NF-κB pathways

(2021) Lin Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway

(2020) Gengyuan Cui et al.   Oxidative Medicine and Cellular Longevity

Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway

(2020) Lin Li et al.   MOLECULES

LIPID PEROXIDATION IN ATHEROSCLEROTIC CARDIOVASCULAR DISEASES

(2020) Erica Gianazza et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

NRF2, a Transcription Factor for Stress Response and Beyond

(2020) Feng He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effect of Astaxanthin on Blue Light Light-Emitting Diode-Induced Retinal Cell Damage via Free Radical Scavenging and Activation of PI3K/Akt/Nrf2 Pathway in 661W Cell Model

(2020) Chao-Wen Lin et al.   Marine Drugs

Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging

(2020) Vincenzo Sorrenti et al.   Marine Drugs

Astaxanthin Protects Retinal Photoreceptor Cells against High Glucose-Induced Oxidative Stress by Induction of Antioxidant Enzymes via the PI3K/Akt/Nrf2 Pathway

(2020) Tso-Ting Lai et al.   Antioxidants

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

(2020) Sarmistha Saha et al.   MOLECULES

Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells

(2019) Maryam Hormozi et al.   Artificial Cells Nanomedicine and Biotechnology

Astaxanthin from Shrimp Cephalothorax Stimulates the Immune Response by Enhancing IFN-γ, IL-10, and IL-2 Secretion in Splenocytes of Helicobacter Pylori-Infected Mice

(2019) Davinelli et al.   Marine Drugs

Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway

(2019) Weixiang Xu et al.   Toxins

Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice

(2019) Hiroaki Kubo et al.   Marine Drugs

Astaxanthin isomers: Selective distribution and isomerization in aquatic animals

(2019) Wenjie Yu et al.   AQUACULTURE

Anti-inflammatory effect of astaxanthin in phthalic anhydride-induced atopic dermatitis animal model

(2018) Ju Ho Park et al.   EXPERIMENTAL DERMATOLOGY

Dietary Carotenoid Roles in Redox Homeostasis and Human Health

(2018) Marcelo P. Barros et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Composite Supplement Containing Astaxanthin and Sesamin on Cognitive Functions in People with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial

(2018) Naoki Ito et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of astaxanthin-rich extract derived from Paracoccus carotinifaciens on cognitive function in middle-aged and older individuals

(2018) Masahiro Hayashi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Astaxanthin Promotes Nrf2/ARE Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs

(2018) Qing Chen et al.   Marine Drugs

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review

(2018) Sergio Davinelli et al.   Nutrients

The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats

(2018) Yonghao Feng et al.   Frontiers in Pharmacology

Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners

(2018) Callie Farruggia et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NFκB/SIRT1 pathway and mitigating oxidative stress

(2018) Hatice Iskender et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats

(2018) Yugang Xue et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Protective effects of astaxanthin on skin deterioration

(2017) Kumi Tominaga et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers

(2017) Natalya E. Chalyk et al.   NUTRITION RESEARCH

Astaxanthin as feed supplement in aquatic animals

(2017) Keng Chin Lim et al.   Reviews in Aquaculture

Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis

(2017) Xiao-Lei Xue et al.   Stem Cell Research & Therapy

Potential Anti-Atherosclerotic Properties of Astaxanthin

(2016) Yoshimi Kishimoto et al.   Marine Drugs

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

(2016) Sergio Davinelli et al.   Immunity & Ageing

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

(2016) Hua Zhang et al.   Current Opinion in Food Science

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro

(2015) Jingjing Li et al.   Marine Drugs

Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin

(2015) Li Zhang et al.   Marine Drugs

The antioxidant effect of astaxanthin is higher in young mice than aged: a region specific study on brain

(2015) Md. Mamun Al-Amin et al.   METABOLIC BRAIN DISEASE

Elevation of HO-1 Expression Mitigates Intestinal Ischemia-Reperfusion Injury and Restores Tight Junction Function in a Rat Liver Transplantation Model

(2015) Xinjin Chi et al.   Oxidative Medicine and Cellular Longevity

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

(2015) Yinhua Ni et al.   Scientific Reports

Altered expression pattern of Nrf2/HO-1 axis during accelerated-senescence in HIV-1 transgenic rat

(2014) Sergio Davinelli et al.   BIOGERONTOLOGY

Astaxanthin inhibits apoptosis in alveolar epithelial cells type IIin vivo and in vitrothrough the ROS-dependent mitochondrial signalling pathway

(2014) Xiaodong Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Supplementing with Dietary Astaxanthin Combined with Collagen Hydrolysate Improves Facial Elasticity and Decreases Matrix Metalloproteinase-1 and -12 Expression: A Comparative Study with Placebo

(2014) Hyun-Sun Yoon et al.   JOURNAL OF MEDICINAL FOOD

Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury

(2014) Qi Wu et al.   Marine Drugs

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

(2014) Ranga Ambati et al.   Marine Drugs

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer

(2013) K. Kavitha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of oxidative stress during inflammatory processes

(2013) Jérôme Lugrin et al.   BIOLOGICAL CHEMISTRY

Redox activation of Nrf2 & NF-κB: A double end sword?

(2013) Mabel Buelna-Chontal et al.   CELLULAR SIGNALLING

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

(2013) Hemant Kumar et al.   NATURAL PRODUCT REPORTS

Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages

(2012) Makoto Inoue et al.   BIOCHEMICAL PHARMACOLOGY

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Astaxanthin prevents loss of insulin signaling and improves glucose metabolism in liver of insulin resistant mice

(2012) Saravanan Bhuvaneswari et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study

(2012) Mikiyuki Katagiri et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Astaxanthin Treatment Reduced Oxidative Induced Pro-Inflammatory Cytokines Secretion in U937: SHP-1 as a Novel Biological Target

(2012) Lorenza Speranza et al.   Marine Drugs

Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells

(2011) Xia Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages

(2011) Anne-Marie Kuhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astaxanthin increases choroidal blood flow velocity

(2011) Michiyuki Saito et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Positive Effects of Astaxanthin on Lipid Profiles and Oxidative Stress in Overweight Subjects

(2011) Hye Duck Choi et al.   PLANT FOODS FOR HUMAN NUTRITION

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells

(2010) Hong-Quan Wang et al.   BRAIN RESEARCH

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan-induced diabetic rats

(2010) M. F. Leite et al.   INTERNATIONAL ENDODONTIC JOURNAL

Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microglia

(2010) Yeon Hyang Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

(2010) Jean Park et al.   Nutrition & Metabolism

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

(2010) Ilaria Bellezza et al.   Cancers

Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia

(2009) Hiroshi Yoshida et al.   ATHEROSCLEROSIS

Targeting the redox sensitive Nrf2–Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones

(2009) Giovanni E Mann et al.   CURRENT OPINION IN PHARMACOLOGY

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

The Chemistry of Novel Xanthophyll Carotenoids

(2008) Henry Jackson et al.   AMERICAN JOURNAL OF CARDIOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Astaxanthin, canthaxanthin and β-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes

(2008) Emanuela Camera et al.   EXPERIMENTAL DERMATOLOGY

Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling

(2008) Narayanan Sriram et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS