Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin

miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14

(2015) Y. Li et al.   CANCER RESEARCH

Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy

(2015) Joaquim Bosch-Barrera et al.   CANCER TREATMENT REVIEWS

Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells

(2015) Chongwen Xu et al.   CELL CYCLE

Nrf2 promotes survival following exposure to ionizing radiation

(2015) Konjeti R. Sekhar et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cinobufagin exerts anti-proliferative and pro-apoptotic effects through the modulation ROS-mediated MAPKs signaling pathway

(2015) Seung Ho Baek et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Cancer prevention and therapy through the modulation of the tumor microenvironment

(2015) Stephanie C. Casey et al.   SEMINARS IN CANCER BIOLOGY

ANXA1 Silencing Increases the Sensitivity of Cancer Cells to Low-concentration Arsenic Trioxide Treatment by Inhibiting ERK MAPK Activation

(2015) Xueyan Zhang et al.   TUMORI

Inflammaging and Cancer: A Challenge for the Mediterranean Diet

(2015) Rita Ostan et al.   Nutrients

Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3

(2015) Shicong Zhu et al.   Oncotarget

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment

(2015) Tim Schumann et al.   Oncotarget

Targeting the Innate Immune System as Immunotherapy for Acute Myeloid Leukemia

(2015) Emily Curran et al.   Frontiers in Oncology

ANXA1 Silencing Increases the Sensitivity of Cancer Cells to Low-concentration Arsenic Trioxide Treatment by Inhibiting ERK MAPK Activation

(2015) Xueyan Zhang et al.   TUMORI JOURNAL

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis

(2015) Jingjing Li et al.   PLoS One

Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma

(2015) Yanchun Liu et al.   PLoS One

Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway

(2015) Ning Zhang et al.   Oncotarget

Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways

(2014) Li Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1, p62 and NBR1) in human bladder cancer cells

(2014) Mohammad Ishaq et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo

(2014) P. Gallipoli et al.   BLOOD

The immune contexture of primary and metastatic human tumours

(2014) Nicolas A Giraldo et al.   CURRENT OPINION IN IMMUNOLOGY

Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage

(2014) Xiang-Sheng Zhang et al.   JOURNAL OF NEUROSURGERY

Astaxanthin Alleviates Early Brain Injury Following Subarachnoid Hemorrhage in Rats: Possible Involvement of Akt/Bad Signaling

(2014) Xiang-Sheng Zhang et al.   Marine Drugs

Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury

(2014) Qi Wu et al.   Marine Drugs

Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy

(2014) Miao Shen et al.   MEDIATORS OF INFLAMMATION

Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O2− Production

(2014) Sara Franceschelli et al.   PLoS One

Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer

(2014) J. Kowshik et al.   PLoS One

Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways

(2014) Li Zhang et al.   TOXICOLOGY LETTERS

Regulation of gap junction channels by infectious agents and inflammation in the CNS

(2014) Paul Castellano et al.   Frontiers in Cellular Neuroscience

Role of PPARγin the Differentiation and Function of Neurons

(2014) Rodrigo A. Quintanilla et al.   PPAR Research

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer

(2013) K. Kavitha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2

(2013) W.-T. Liao et al.   CLINICAL CANCER RESEARCH

JAKs and STATs in Immunity, Immunodeficiency, and Cancer

(2013) John J. O'Shea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy

(2013) Supak Yothaisong et al.   TUMOR BIOLOGY

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

(2012) Neng-Yu Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Combined astaxanthin and fish oil supplementation improves glutathione-based redox balance in rat plasma and neutrophils

(2012) Marcelo Paes Barros et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Antitumor Effect of GDC-0941 Alone and in Combination with Rapamycin in Breast Cancer Cells

(2012) Jie Zheng et al.   CHEMOTHERAPY

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK

(2012) Simiao Fan et al.   FREE RADICAL RESEARCH

Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto–Kakizaki (GK) rats: ameliorating effects of (−)-epigallocatechin-3-gallate

(2012) Jiong Yan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Astaxanthin Treatment Reduced Oxidative Induced Pro-Inflammatory Cytokines Secretion in U937: SHP-1 as a Novel Biological Target

(2012) Lorenza Speranza et al.   Marine Drugs

Cancer Chemoprevention by Carotenoids

(2012) Takuji Tanaka et al.   MOLECULES

Aspirin as adjuvant therapy for colorectal cancer—reinterpreting paradigms

(2012) Whay Kuang Chia et al.   Nature Reviews Clinical Oncology

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

(2012) T Yamadori et al.   ONCOGENE

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

Changes in cell ultrastructure and inhibition of JAK1/STAT3 signaling pathway in CBRH-7919 cells with astaxanthin

(2012) Xiaodong Song et al.   TOXICOLOGY MECHANISMS AND METHODS

Targeting PPARγSignaling Cascade for the Prevention and Treatment of Prostate Cancer

(2012) Sakshi Sikka et al.   PPAR Research

Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells

(2011) Xia Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Astaxanthin Induces Mitochondria-Mediated Apoptosis in Rat Hepatocellular Carcinoma CBRH-7919 Cells

(2011) Xiao-dong Song et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines

(2011) Yumiko Yasui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

JAK-STAT signaling in hepatic fibrosis

(2011) Markus Mair   Frontiers in Bioscience-Landmark

PPARγ disease gene network and identification of therapeutic targets for prostate cancer

(2011) Gireedhar Venkatachalam et al.   JOURNAL OF DRUG TARGETING

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

(2011) Reason Wilken et al.   Molecular Cancer

Apoptosis and Other Cell Death Mechanisms after Retinal Detachment: Implications for Photoreceptor Rescue

(2011) Amy C.Y. Lo et al.   OPHTHALMOLOGICA

Mammalian target of rapamycin: Biological function and target for novel anticancer agents

(2010) E. B. Borders et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Neuroprotective effect of astaxanthin on H 2 O 2 -induced neurotoxicity in vitro and on focal cerebral ischemia in vivo

(2010) Ya-Peng Lu et al.   BRAIN RESEARCH

p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

(2010) Paolo Pinton et al.   CELL CYCLE

Mast cell homeostasis and the JAK–STAT pathway

(2010) J K Morales et al.   GENES AND IMMUNITY

Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways

(2010) Kung-Wen Lu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

(2010) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JAK/STAT signaling in renal diseases

(2010) Peter Y. Chuang et al.   KIDNEY INTERNATIONAL

Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway

(2010) Kil-Nam Kim et al.   TOXICOLOGY IN VITRO

MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP

(2009) Craig W. Younce et al.   BIOCHEMICAL JOURNAL

Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells

(2009) Paola Palozza et al.   CANCER LETTERS

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Astaxanthin reduces ischemic brain injury in adult rats

(2009) Hui Shen et al.   FASEB JOURNAL

Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2

(2009) Ponnuraj Nagendraprabhu et al.   INVESTIGATIONAL NEW DRUGS

NF-κB signalling proteins p50/p105, p52/p100, RelA, and IKKε are over-expressed in oesophageal squamous cell carcinomas

(2009) Mi Ran Kang et al.   PATHOLOGY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Expression of NF-E2-Related Factor 2 in the Rat Brain After Traumatic Brain Injury

(2009) Wei Yan et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Astaxanthin: A Novel Potential Treatment for Oxidative Stress and Inflammation in Cardiovascular Disease

(2008) Fredric J. Pashkow et al.   AMERICAN JOURNAL OF CARDIOLOGY

Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism

(2008) Xuebo Liu et al.   BRAIN RESEARCH

Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy

(2008) Mayumi Ono   CANCER SCIENCE

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

(2008) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells

(2008) Yasutaka Ikeda et al.   JOURNAL OF NEUROCHEMISTRY

Inflammatory processes in preterm and term parturition

(2008) Inge Christiaens et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Resveratrol addiction: To die or not to die

(2008) Mehdi Shakibaei et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults

(2007) W OSBURN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH