Recent Advances in Molecular Pathways and Therapeutic Implications Targeting Mitochondrial Dysfunction for Alzheimer’s Disease

Carvedilol Exerts Neuroprotective Effect on Rat Model of Diabetic Neuropathy

(2021) Rania M. Magadmi et al.   Frontiers in Pharmacology

EGb761 ameliorates cell necroptosis by attenuating RIP1-mediated mitochondrial dysfunction and ROS production in both in vivo and in vitro models of Alzheimer’s disease

(2020) Wei-Ping Chen et al.   BRAIN RESEARCH

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

(2020) Qian Cai et al.   Cells

The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain

(2020) Taskeen Fathima Docrat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alpha lipoic acid and vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats

(2020) Hatice Eser Faki et al.   MITOCHONDRION

Arabidopsis Voltage-Dependent Anion Channels (VDACs): Overlapping and Specific Functions in Mitochondria

(2020) Mickaële Hemono et al.   Cells

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

(2020) Ian W. Weidling et al.   EXPERIMENTAL NEUROLOGY

The distinctive role of tau and amyloid beta in mitochondrial dysfunction through alteration in Mfn2 and Drp1 mRNA Levels: A comparative study in Drosophila melanogaster

(2020) Seyedeh Leila Abtahi et al.   GENE

Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson’s disease

(2020) Yanhua Shen et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death

(2020) Maria Calvo-Rodriguez et al.   TRENDS IN NEUROSCIENCES

The peacefulness gene promotes aggression in Drosophila

(2019) Mahmoudreza Ramin et al.   Molecular Brain

Structure and Function of IP3 Receptors

(2019) David L. Prole et al.   Cold Spring Harbor Perspectives in Biology

The impact of curcumin and its modified formulations on Alzheimer's disease

(2019) Tahereh Farkhondeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction

(2019) Yi-Jun Xu et al.   BRAIN RESEARCH

Small molecules as therapeutic drugs for Alzheimer's disease

(2019) Darryll M.A. Oliver et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system

(2019) Ursula Quitterer et al.   PHARMACOLOGICAL RESEARCH

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke

(2019) Syed Suhail Andrabi et al.   Disease Models & Mechanisms

Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

(2019) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Can magnesium reduce central neurodegeneration in Alzheimer's disease? Basic evidences and research needs

(2019) Dènahin Hinnoutondji Toffa et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial fusion is required for regulation of mitochondrial DNA replication

(2019) Eduardo Silva Ramos et al.   PLoS Genetics

Gingko biloba Extract (EGb) Inhibits Oxidative Stress in Neuro 2A Cells Overexpressing APPsw

(2019) Le Chen et al.   Biomed Research International

Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives

(2019) Chiara Lanzillotta et al.   CNS DRUGS

AMPK: Potential Therapeutic Target for Alzheimer's disease

(2019) Luping Yang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer's disease and depressive disorder

(2019) Zdeněk Fišar et al.   MITOCHONDRION

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

(2019) Melissa L. Young et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders

(2019) Sandeep Kumar Singh et al.   Neurotherapeutics

Cerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model

(2019) Sina Qin et al.   Drug Design Development and Therapy

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

(2019) Giovanna Cenini et al.   Frontiers in Pharmacology

Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range

(2019) N. A. Vasilieva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Effects of Docosahexaenoic Acid and Its Peroxidation Product on Amyloid-β Peptide-Stimulated Microglia

(2019) Xue Geng et al.   MOLECULAR NEUROBIOLOGY

Equol Pretreatment Protection of SH-SY5Y Cells against Aβ (25–35)-Induced Cytotoxicity and Cell-Cycle Reentry via Sustaining Estrogen Receptor Alpha Expression

(2019) Meng-Chao Tsai et al.   Nutrients

The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

(2019) S.D. Voulgaropoulou et al.   BRAIN RESEARCH

Epileptiform activity promotes decreasing of Ca2+ conductivity of NMDARs, AMPARs, KARs, and voltage-gated calcium channels in Mg2+-free model

(2019) Sergei G. Gaidin et al.   EPILEPSY RESEARCH

Dysregulation of Autophagy, Mitophagy, and Apoptosis Genes in the CA3 Region of the Hippocampus in the Ischemic Model of Alzheimer’s Disease in the Rat

(2019) Marzena Ułamek-Kozioł et al.   JOURNAL OF ALZHEIMERS DISEASE

Retinal Imaging in Alzheimer’s Disease: In Search of the Holy Grail

(2019) Amani A. Fawzi et al.   OPHTHALMOLOGY

p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease

(2019) Chen Gui et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

(2018) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

New insights into the role of mitochondrial calcium homeostasis in cell migration

(2018) Vincent Paupe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion

(2018) Tadato Ban et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

(2018) Ye Xi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

(2018) Saverio Marchi et al.   CELL CALCIUM

Carvedilol protection against endogenous Aβ-induced neurotoxicity in N2a cells

(2018) Jia Liu et al.   CELL STRESS & CHAPERONES

ROS as Regulators of Mitochondrial Dynamics in Neurons

(2018) Carolina Cid-Castro et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

(2018) Inhae Kang et al.   FEBS LETTERS

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease

(2018) P Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

N -acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease

(2018) Erzsebet Polyak et al.   MOLECULAR GENETICS AND METABOLISM

Comparative effects of avocado oil and losartan on blood pressure, renal vascular function, and mitochondrial oxidative stress in hypertensive rats

(2018) Cristian Adrián Márquez-Ramírez et al.   NUTRITION

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients

(2018) Julian H. Birnbaum et al.   Stem Cell Research

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Ying Cheng et al.   Frontiers in Neuroscience

Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage

(2018) Tongyu Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection

(2018) Ali Reza Khalatbary et al.   NUTRITIONAL NEUROSCIENCE

Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial

(2018) Brian Lawlor et al.   PLOS MEDICINE

Mitochondrial Pharmacology of Dimebon (Latrepirdine) Calls for a New Look at its Possible Therapeutic Potential in Alzheimer’s Disease

(2018) Schamim H Eckert et al.   Aging and Disease

Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases

(2018) Jie Wu et al.   FREE RADICAL RESEARCH

Neurochemical effects of the R form of α-lipoic acid and its neuroprotective mechanism in cellular models of Parkinson’s disease

(2017) Hong Zhao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

(-)-Epigallocatechin-3-gallate Ameliorates Insulin Resistance and Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1

(2017) Yashi Mi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

dl-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling Pathway

(2017) Zhengwei Liu et al.   NEUROCHEMICAL RESEARCH

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme

(2016) Marcus O.W. Grimm et al.   Biochemistry and Cell Biology

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

(2016) Dah Ihm Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction

(2016) Ming-Chang Chiang et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

(2016) Isaac G. Onyango et al.   Aging and Disease

PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease

(2015) Patricia Martín-Maestro et al.   HUMAN MOLECULAR GENETICS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP

(2013) Ari Robinson et al.   AGING CELL

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Physiological functions of mitochondrial fusion

(2010) Hsiuchen Chen et al.   Annals of the New York Academy of Sciences

Alzheimer Disease

(2010) Rudy J. Castellani et al.   DM DISEASE-A-MONTH

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Mitochondrial dysfunction and Alzheimer's disease

(2010) Aleksandra Maruszak et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE