RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics

The tumor microenvironment impairs Th1 IFNγ secretion through alternative splicing modifications of Irf1 pre-mRNA

(2021) Antoine Bernard et al.   Cancer Immunology Research

N6-methyladenosine (m6A)-mediated messenger RNA signatures and the tumor immune microenvironment can predict the prognosis of hepatocellular carcinoma

(2021) Shen Shen et al.   Annals of Translational Medicine

Pan-cancer analysis of ligand-receptor crosstalk in the tumor microenvironment

(2021) Umesh Ghoshdastider et al.   CANCER RESEARCH

mRNA vaccine for cancer immunotherapy

(2021) Lei Miao et al.   Molecular Cancer

The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy

(2021) Zhixiao Fang et al.   Frontiers in Immunology

Recent Advances in Oligonucleotide Therapeutics in Oncology

(2021) Haoyu Xiong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The evolving landscape of N6-methyladenosine modification in the tumor microenvironment

(2021) Yunru Gu et al.   MOLECULAR THERAPY

Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression

(2021) Yingying Xing et al.   Frontiers in Immunology

Therapeutic inhibitory RNA in head and neck cancer via functional targeted lipid nanoparticles

(2021) Liyona Kampel et al.   JOURNAL OF CONTROLLED RELEASE

Emerging strategies to target RAS signaling in human cancer therapy

(2021) Kun Chen et al.   Journal of Hematology & Oncology

Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response

(2021) Tong Fu et al.   Journal of Hematology & Oncology

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

(2021) Jaclyn M. Einstein et al.   MOLECULAR CELL

Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

(2021) Christian Hotz et al.   Science Translational Medicine

Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

(2021) Yao-Xin Lin et al.   Science Translational Medicine

Long Non-Coding RNAs in the Tumor Immune Microenvironment: Biological Properties and Therapeutic Potential

(2021) Ya-Nan Pi et al.   Frontiers in Immunology

Assessing and Management of Neurotoxicity After CAR-T Therapy in Diffuse Large B-Cell Lymphoma

(2021) Omar Castaneda-Puglianini et al.   Journal of Blood Medicine

Results of the ADAPT phase 3 study of Rocapuldencel-T in combination with sunitinib as first-line therapy in patients with metastatic renal cell carcinoma

(2020) Robert A. Figlin et al.   CLINICAL CANCER RESEARCH

TLR3 Expression Induces Apoptosis in Human Non-Small-Cell Lung Cancer

(2020) Francesca Bianchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular nanovesicles‐transmitted circular RNA has_circ_0000190 suppresses osteosarcoma progression

(2020) Shenglong Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Noncoding RNAs in cancer immunity: functions, regulatory mechanisms, and clinical application

(2020) Le Zhang et al.   Molecular Cancer

RNA-based pharmacotherapy for tumors: From bench to clinic and back

(2020) Xiangping Liang et al.   BIOMEDICINE & PHARMACOTHERAPY

The role of cancer-derived microRNAs in cancer immune escape

(2020) Ming Yi et al.   Journal of Hematology & Oncology

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

(2020) Ugur Sahin et al.   NATURE

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

(2020) Na Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1

(2020) Theresa A. Proia et al.   CLINICAL CANCER RESEARCH

Mouse 4T1 Breast Cancer Cell–Derived Exosomes Induce Proinflammatory Cytokine Production in Macrophages via miR-183

(2020) Jian Guo et al.   JOURNAL OF IMMUNOLOGY

Tumoural activation of TLR3–SLIT2 axis in endothelium drives metastasis

(2020) Bernardo Tavora et al.   NATURE

Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis

(2020) Minhong Shen et al.   CANCER RESEARCH

Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer

(2020) Senlin Zhao et al.   Journal of Hematology & Oncology

Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

(2020) Simeng Wen et al.   Molecular Cancer

Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells

(2020) Nina Guyon et al.   Cell Death & Disease

Releasing the Immune System Brakes Using siRNAs Enhances Cancer Immunotherapy

(2019) Mouldy Sioud   Cancers

Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity

(2019) Abhishek S. Kashyap et al.   Journal for ImmunoTherapy of Cancer

Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

(2019) Alexandros Papachristofilou et al.   Journal for ImmunoTherapy of Cancer

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

(2019) Susannah L. Hewitt et al.   Science Translational Medicine

LncRNA GAS5 enhanced the killing effect of NK cell on liver cancer through regulating miR-544/RUNX3

(2019) Peipei Fang et al.   Innate Immunity

miR3609 sensitizes breast cancer cells to adriamycin by blocking the programmed death-ligand 1 immune checkpoint

(2019) Duolu Li et al.   EXPERIMENTAL CELL RESEARCH

The Landscape of Circular RNA in Cancer

(2019) Josh N. Vo et al.   CELL

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

(2019) Martin Sebastian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Therapeutic Antisense Oligonucleotides Are Coming of Age

(2019) C. Frank Bennett   Annual Review of Medicine

Repression of lncRNA NEAT1 enhances the antitumor activity of CD8+T cells against hepatocellular carcinoma via regulating miR-155/Tim-3

(2019) Kai Yan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Immunomodulatory MicroRNAs in cancer: targeting immune checkpoints and the tumor microenvironment

(2019) Hany A. Omar et al.   FEBS Journal

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

(2019) Yuxin Lin et al.   Journal of Hematology & Oncology

Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN

(2019) Qun Lu et al.   Molecular Cancer

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

(2019) Qingsong Hu et al.   NATURE IMMUNOLOGY

Long Non-coding RNAs: Regulators of the Activity of Myeloid-Derived Suppressor Cells

(2019) Gabriela Leija Montoya et al.   Frontiers in Immunology

Methods for analysis of circular RNAs

(2019) Poonam R. Pandey et al.   Wiley Interdisciplinary Reviews-RNA

Harnessing Natural Killer Cell Antitumor Immunity: From the Bench to Bedside

(2019) Karrune V. Woan et al.   Cancer Immunology Research

Mechanisms of Relapse After CD19 CAR T-Cell Therapy for Acute Lymphoblastic Leukemia and Its Prevention and Treatment Strategies

(2019) Xinjie Xu et al.   Frontiers in Immunology

The Role of Long Non-coding RNAs in Immunotherapy Resistance

(2019) Yuwen Zhou et al.   Frontiers in Oncology

EBV microRNA-BHRF1-2-5p targets the 3′UTR of immune checkpoint ligands PD-L1 and PD-L2

(2019) Alexandre S. Cristino et al.   BLOOD

Comparison of DNA and mRNA vaccines against cancer

(2019) Zohreh Jahanafrooz et al.   DRUG DISCOVERY TODAY

Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment

(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

Targeting myeloid-derived suppressor cells for cancer immunotherapy

(2018) Yijun Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

RNA-Targeted Therapeutics

(2018) Stanley T. Crooke et al.   Cell Metabolism

Epstein−Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas

(2018) Eleni Anastasiadou et al.   LEUKEMIA

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC

(2018) Jie Ji et al.   Cell Death & Disease

Widespread intronic polyadenylation diversifies immune cell transcriptomes

(2018) Irtisha Singh et al.   Nature Communications

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

(2018) André Kahles et al.   CANCER CELL

Lnc-DC regulates cellular turnover and the HBV-induced immune response by TLR9/STAT3 signaling in dendritic cells

(2018) Lifan Zhuang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

MicroRNA-497-5p down-regulation increases PD-L1 expression in clear cell renal cell carcinoma

(2018) Fajun Qu et al.   JOURNAL OF DRUG TARGETING

T7 Peptide-Conjugated Lipid Nanoparticles for Dual Modulation of Bcl-2 and Akt-1 in Lung and Cervical Carcinomas

(2018) Xinwei Cheng et al.   MOLECULAR PHARMACEUTICS

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia

(2018) Shih-Han Lee et al.   NATURE

NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death

(2018) Di Huang et al.   NATURE IMMUNOLOGY

An RNA toolbox for cancer immunotherapy

(2018) Fernando Pastor et al.   NATURE REVIEWS DRUG DISCOVERY

Cytokines in clinical cancer immunotherapy

(2018) Pedro Berraondo et al.   BRITISH JOURNAL OF CANCER

Natural Killer-derived exosomal miR-186 inhibits neuroblastoma growth and immune escape mechanisms.

(2018) Paolo Neviani et al.   CANCER RESEARCH

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation

(2018) Sara J. Dubbury et al.   NATURE

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

(2018) Matthew J. Reilley et al.   Journal for ImmunoTherapy of Cancer

Second- and third-generation drugs for immuno-oncology treatment—The more the better?

(2017) Wolfram C.M. Dempke et al.   EUROPEAN JOURNAL OF CANCER

Targeting Immune Checkpoints in Cancer Therapy

(2017) Suzanne L. Topalian   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses

(2017) Nicholas W. Mathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

Aptamer-Targeted Attenuation of IL-2 Signaling in CD8 + T Cells Enhances Antitumor Immunity

(2017) Anugraha Rajagopalan et al.   MOLECULAR THERAPY

Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels

(2017) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA)

(2017) Mario Martínez Soldevilla et al.   PLoS One

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

(2017) Sarah J. Ross et al.   Science Translational Medicine

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

(2017) Daniel Ajona et al.   Cancer Discovery

Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade

(2017) Dirk Zboralski et al.   Cancer Immunology Research

Monocyte-Derived Dendritic Cells with Silenced PD-1 Ligands and Transpresenting Interleukin-15 Stimulate Strong Tumor-Reactive T-cell Expansion

(2017) Johan M.J. Van den Bergh et al.   Cancer Immunology Research

Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma

(2017) Jing Lin et al.   Molecular Therapy-Nucleic Acids

Targeting inhibition of Foxp3 by a CD28 2′-Fluro oligonucleotide aptamer conjugated to P60-peptide enhances active cancer immunotherapy

(2016) Teresa Lozano et al.   BIOMATERIALS

4-1BB agonism: adding the accelerator to cancer immunotherapy

(2016) Cariad Chester et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation

(2016) Shi-Yong Li et al.   JOURNAL OF CONTROLLED RELEASE

Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

(2016) Richard S Finkel et al.   LANCET

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy

(2016) Dangge Wang et al.   NANO LETTERS

Myeloid cells as orchestrators of the tumor microenvironment: novel targets for nanoparticular cancer therapy

(2016) Andrea Tuettenberg et al.   Nanomedicine

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames

(2016) Xue-hai Liang et al.   NATURE BIOTECHNOLOGY

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

(2016) Mario Martínez Soldevilla et al.   Oncotarget

Utilising inorganic nanocarriers for gene delivery

(2016) Xian Jun Loh et al.   Biomaterials Science

Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer

(2016) Thomas K Ni et al.   eLife

Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

(2016) William M Mitchell   Expert Review of Clinical Pharmacology

Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy

(2016) Wei He et al.   Scientific Reports

Preclinical and clinical development of siRNA-based therapeutics

(2015) Gulnihal Ozcan et al.   ADVANCED DRUG DELIVERY REVIEWS

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8+ T cells in NOD/SCID/IL2Rg(null) mice

(2015) Anniek B. van der Waart et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Differentiation of mammary tumors and reduction in metastasis uponMalat1lncRNA loss

(2015) Gayatri Arun et al.   GENES & DEVELOPMENT

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Identification of TIM3 2’-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy

(2015) Sandra Hervas-Stubbs et al.   Oncotarget

Long-term survival correlates with immunological responses in renal cell carcinoma patients treated with mRNA-based immunotherapy

(2015) Susanne M. Rittig et al.   OncoImmunology

Phase I clinical trial of adoptive cellular immunotherapy with APN401 in patients with solid tumors

(2015) Pierre Triozzi et al.   Journal for ImmunoTherapy of Cancer

Survival with AGS-003, an autologous dendritic cell–based immunotherapy, in combination with sunitinib in unfavorable risk patients with advanced renal cell carcinoma (RCC): Phase 2 study results

(2015) Asim Amin et al.   Journal for ImmunoTherapy of Cancer

Nanoparticle-Delivered Transforming Growth Factor-β siRNA Enhances Vaccination against Advanced Melanoma by Modifying Tumor Microenvironment

(2014) Zhenghong Xu et al.   ACS Nano

Polymer nanoparticles for enhanced immune response: Combined delivery of tumor antigen and small interference RNA for immunosuppressive gene to dendritic cells

(2014) Min Beom Heo et al.   Acta Biomaterialia

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

(2014) Andreas Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic targeting of microRNAs: current status and future challenges

(2014) Zhonghan Li et al.   NATURE REVIEWS DRUG DISCOVERY

The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

(2014) P. Wang et al.   SCIENCE

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Long non-coding RNAs and control of gene expression in the immune system

(2014) Maninjay K. Atianand et al.   TRENDS IN MOLECULAR MEDICINE

T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy

(2014) I. Melero et al.   Cancer Discovery

Targeting 4-1BB Costimulation to the Tumor Stroma with Bispecific Aptamer Conjugates Enhances the Therapeutic Index of Tumor Immunotherapy

(2014) B. Schrand et al.   Cancer Immunology Research

Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression

(2013) S. Lianoglou et al.   GENES & DEVELOPMENT

Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity

(2013) Alexey Berezhnoy et al.   JOURNAL OF CLINICAL INVESTIGATION

Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis

(2013) Yuhua Wang et al.   MOLECULAR THERAPY

Alternative cleavage and polyadenylation: extent, regulation and function

(2013) Ran Elkon et al.   NATURE REVIEWS GENETICS

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Reprogramming Tumor-Associated Dendritic Cells In Vivo Using miRNA Mimetics Triggers Protective Immunity against Ovarian Cancer

(2012) J. R. Cubillos-Ruiz et al.   CANCER RESEARCH

Cationic polymers and their therapeutic potential

(2012) Sangram Keshari Samal et al.   CHEMICAL SOCIETY REVIEWS

Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model

(2012) Xiufen Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

(2012) Alexey Berezhnoy et al.   MOLECULAR THERAPY

Overcoming HLA restriction in clinical trials

(2012) An M.T. Van Nuffel et al.   OncoImmunology

Gene silencing of TGF-β1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells

(2011) Helen Conroy et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Blocking the immunosuppressive axis with small interfering RNA targeting interleukin (IL)-10 receptor enhances dendritic cell-based vaccine potency

(2011) J. H. Kim et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

(2011) Fernando Pastor et al.   MOLECULAR THERAPY

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Cytokines in Cancer Immunotherapy

(2011) Sylvia Lee et al.   Cancers

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

Hypercostimulation through 4-1BB Distorts Homeostasis of Immune Cells

(2009) S.-W. Lee et al.   JOURNAL OF IMMUNOLOGY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY