Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
Authors
Keywords
-
Journal
Science Translational Medicine
Volume 13, Issue 610, Pages -
Publisher
American Association for the Advancement of Science (AAAS)
Online
2021-09-09
DOI
10.1126/scitranslmed.abc7804
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression
- (2020) Florent Petitprez et al. Genome Medicine
- Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs
- (2019) Susannah L. Hewitt et al. Science Translational Medicine
- Local delivery of OX40L, CD80, and CD86 mRNA kindles global anti-cancer immunity.
- (2019) Ole Audun Werner Haabeth et al. CANCER RESEARCH
- A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA
- (2019) Markus Baiersdörfer et al. Molecular Therapy-Nucleic Acids
- Mechanisms of resistance to immune checkpoint inhibitors
- (2018) Russell W Jenkins et al. BRITISH JOURNAL OF CANCER
- Starting the fight in the tumor: expert recommendations for the development of human intratumoral immunotherapy (HIT-IT)
- (2018) A Marabelle et al. ANNALS OF ONCOLOGY
- Cytokines in clinical cancer immunotherapy
- (2018) Pedro Berraondo et al. BRITISH JOURNAL OF CANCER
- Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening
- (2018) Alexandra G. Orlandini von Niessen et al. MOLECULAR THERAPY
- A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo
- (2018) Mathias Vormehr et al. OncoImmunology
- In situ administration of cytokine combinations induces tumor regression in mice
- (2018) Jinyu Zhang et al. EBioMedicine
- IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade
- (2017) Mark Ayers et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumour heterogeneity and resistance to cancer therapies
- (2017) Ibiayi Dagogo-Jack et al. Nature Reviews Clinical Oncology
- Mutant MHC class II epitopes drive therapeutic immune responses to cancer
- (2015) Sebastian Kreiter et al. NATURE
- Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells
- (2015) S. Van Lint et al. Cancer Immunology Research
- Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity
- (2015) Kevin Van der Jeught et al. Oncotarget
- Cytokine therapy reverses NK cell anergy in MHC-deficient tumors
- (2014) Michele Ardolino et al. JOURNAL OF CLINICAL INVESTIGATION
- Therapeutic Activity of High-Dose Intratumoral IFN-β Requires Direct Effect on the Tumor Vasculature
- (2014) Robbert M. Spaapen et al. JOURNAL OF IMMUNOLOGY
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells
- (2013) M. J. Selby et al. Cancer Immunology Research
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- U.S. Food and Drug Administration Approval: Peginterferon-alfa-2b for the Adjuvant Treatment of Patients with Melanoma
- (2012) T. M. Herndon et al. ONCOLOGIST
- Direct Effects of Type I Interferons on Cells of the Immune System
- (2011) S. Hervas-Stubbs et al. CLINICAL CANCER RESEARCH
- The Two Faces of Interferon- in Cancer
- (2011) M. R. Zaidi et al. CLINICAL CANCER RESEARCH
- Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
- (2011) Katalin Karikó et al. NUCLEIC ACIDS RESEARCH
- Cytokines in Cancer Immunotherapy
- (2011) Sylvia Lee et al. Cancers
- Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
- (2010) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started