期刊
MOLECULAR CANCER
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12943-022-01528-6
关键词
Cancer; RNA; Nanoparticle; Antibody; Dendritic cells; T cells; Cytokine; Tumor immune microenvironment; RNA therapy; Immunotherapy
资金
- Ramalingaswami grant from the Department of Biotechnology, Ministry of Science and Technology, Government of India [BT/RLF/Re-entry/18/2017]
- Global Research Award, American Society of Hematology 2020, Washington, DC, USA
The tumor immune microenvironment (TIME) plays a crucial role in tumor growth and metastasis by influencing the balance of immune-suppressive and cytotoxic responses. RNA-based therapeutics targeting RNA regulators in the TIME show promise in cancer immunotherapy.
Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. Targeting or activating the TIME components show a promising therapeutic avenue to combat cancer. The success of immunotherapy is both astounding and unsatisfactory in the clinic. Advancements in RNA-based technology have improved understanding of the complexity and diversity of the TIME and its effects on therapy. TIME-related RNA or RNA regulators could be promising targets for anticancer immunotherapy. In this review, we discuss the available RNA-based cancer immunotherapies targeting the TIME. More importantly, we summarize the potential of various RNA-based therapeutics clinically available for cancer treatment. RNA-dependent targeting of the TIME, as monotherapy or combined with other evolving therapeutics, might be beneficial for cancer patients' treatment in the near future.
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