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Title
Integrins as a drug target in liver fibrosis
Authors
Keywords
-
Journal
LIVER INTERNATIONAL
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2022-01-20
DOI
10.1111/liv.15157
References
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Note: Only part of the references are listed.- Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis
- (2021) Norihisa Nishimichi et al. JOURNAL OF PATHOLOGY
- Therapeutic pipeline in nonalcoholic steatohepatitis
- (2021) Raj Vuppalanchi et al. Nature Reviews Gastroenterology & Hepatology
- Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells
- (2021) Zuoning Han et al. BIOCHEMICAL JOURNAL
- New drugs for NASH
- (2021) Somaya A. M. Albhaisi et al. LIVER INTERNATIONAL
- Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial
- (2021) Stephen A. Harrison et al. NATURE MEDICINE
- Selective depletion of hepatic stellate cells‐specific LOXL1 alleviates liver fibrosis
- (2021) Aiting Yang et al. FASEB JOURNAL
- New Therapeutic Targets for Hepatic Fibrosis in the Integrin Family, α8β1 and α11β1, Induced Specifically on Activated Stellate Cells
- (2021) Yasuyuki Yokosaki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Novel targeted therapies for the management of liver fibrosis
- (2020) Juan P. Trivella et al. EXPERT OPINION ON EMERGING DRUGS
- Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials
- (2020) Stephen A. Harrison et al. JOURNAL OF HEPATOLOGY
- The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease
- (2020) F. Anthony Romero et al. JOURNAL OF MEDICINAL CHEMISTRY
- Expression of hepatic stellate cell activation-related genes in HBV-, HCV-, and nonalcoholic fatty liver disease-associated fibrosis
- (2020) Lu He et al. PLoS One
- Effects of Nintedanib in an Animal Model of Liver Fibrosis
- (2020) Lutz Wollin et al. Biomed Research International
- αvβ8 integrin adhesion and signaling pathways in development, physiology and disease
- (2020) Joseph H. McCarty JOURNAL OF CELL SCIENCE
- Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core
- (2020) Rhys A. Lippa et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH
- (2020) Brian Finan et al. Molecular Metabolism
- An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis
- (2019) Yanping Li et al. JOURNAL OF CONTROLLED RELEASE
- Emerging strategies to disrupt the central TGF-β axis in kidney fibrosis
- (2019) Michael Rauchman et al. Translational Research
- Adhesion and growth factor receptor crosstalk mechanisms controlling cell migration
- (2019) Joanna R. Thomas et al. Essays in Biochemistry
- Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis
- (2019) Niall A. Anderson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacotherapy and adjunctive treatment for idiopathic pulmonary fibrosis (IPF)
- (2019) Shigeki Saito et al. Journal of Thoracic Disease
- The therapy of idiopathic pulmonary fibrosis: what is next?
- (2019) Vivien Somogyi et al. European Respiratory Review
- Progress in promising anti-fibrotic therapies
- (2019) Rosanna Santoro et al. Expert Review of Gastroenterology & Hepatology
- The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis
- (2019) Hintermann et al. Cells
- Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
- (2019) Zobair M Younossi et al. LANCET
- TGF-β1 – A truly transforming growth factor in fibrosis and immunity
- (2019) Monika Lodyga et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery
- (2018) Jonas Schnittert et al. ADVANCED DRUG DELIVERY REVIEWS
- An αv-RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities
- (2018) Richard J. D. Hatley et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- High Prevalence of Liver Fibrosis Among European Adults With Unknown Liver Disease: A Population-Based Study
- (2018) Llorenç Caballería et al. Clinical Gastroenterology and Hepatology
- Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants
- (2018) Charlotte H. Maden et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis
- (2018) Shambhu Aryal et al. EXPERT OPINION ON EMERGING DRUGS
- Resolution of organ fibrosis
- (2018) Joon-Il Jun et al. JOURNAL OF CLINICAL INVESTIGATION
- Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening
- (2018) Patrick Marcellin et al. LIVER INTERNATIONAL
- Targeting TGF-β signaling for the treatment of fibrosis
- (2018) Andrea Hermina Györfi et al. MATRIX BIOLOGY
- Liver fibrosis: Direct antifibrotic agents and targeted therapies
- (2018) Detlef Schuppan et al. MATRIX BIOLOGY
- Discovery of (S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis
- (2018) Panayiotis A. Procopiou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacological characterisation of a tool αvβ1 integrin small molecule RGD-mimetic inhibitor
- (2018) Alex L. Wilkinson et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- JKB-122 is effective, alone or in combination with prednisolone in Con A-induced hepatitis
- (2017) Mei-Chi Hsu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins
- (2017) Lisa M. Miller et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacologic Blockade of α v β 1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo
- (2017) Yongen Chang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Integrin extension enables ultrasensitive regulation by cytoskeletal force
- (2017) Jing Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
- (2017) I. R. Murray et al. Nature Communications
- Reversal of liver cirrhosis: current evidence and expectations
- (2017) Young Kul Jung et al. KOREAN JOURNAL OF INTERNAL MEDICINE
- Integrins as Therapeutic Targets: Successes and Cancers
- (2017) Sabine Raab-Westphal et al. Cancers
- Determining the True Selectivity Profile of αv Integrin Ligands Using Radioligand Binding: Applying an Old Solution to a New Problem
- (2017) James E. Rowedder et al. SLAS Discovery
- αv integrins: key regulators of tissue fibrosis
- (2016) Kylie P. Conroy et al. CELL AND TISSUE RESEARCH
- The role of integrins in TGFβ activation in the tumour stroma
- (2016) Zareen Khan et al. CELL AND TISSUE RESEARCH
- Recent progress on targeting the αvβ1 integrin for the treatment of tissue fibrosis
- (2016) James R. Smith et al. Expert Opinion on Drug Discovery
- TGF-β signalling and liver disease
- (2016) Isabel Fabregat et al. FEBS Journal
- In Vivo Imaging in Pharmaceutical Development and Its Impact on the 3Rs
- (2016) Barry R. Campbell et al. ILAR JOURNAL
- TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis
- (2016) Fengyun Xu et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
- (2016) Elena Buzzetti et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Integrin-based therapeutics: biological basis, clinical use and new drugs
- (2016) Klaus Ley et al. NATURE REVIEWS DRUG DISCOVERY
- TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
- (2016) Masato Morikawa et al. Cold Spring Harbor Perspectives in Biology
- αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease
- (2015) Gauri Saini et al. EUROPEAN RESPIRATORY JOURNAL
- Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis
- (2015) Zhen-Wei Peng et al. HEPATOLOGY
- Hepatic inflammation and fibrosis: Functional links and key pathways
- (2015) Ekihiro Seki et al. HEPATOLOGY
- Role and New Insights of Pirfenidone in Fibrotic Diseases
- (2015) David Alejandro Lopez-de la Mora et al. International Journal of Medical Sciences
- Hepatic fibrosis: Concept to treatment
- (2015) Christian Trautwein et al. JOURNAL OF HEPATOLOGY
- Antifibrotic Therapies in the Liver
- (2015) D. Schuppan et al. SEMINARS IN LIVER DISEASE
- Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis
- (2014) Satish K. Madala et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction
- (2014) Vincent Sarrazy et al. CARDIOVASCULAR RESEARCH
- Integrin β-8, But Not β-5 or -6, Protein Expression Is Increased in Livers of Children With Biliary Atresia
- (2014) Tatiana Iordanskaia et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Selective Targeting of TGF- Activation to Treat Fibroinflammatory Airway Disease
- (2014) S. Minagawa et al. Science Translational Medicine
- Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents
- (2014) James Adams et al. ACS Medicinal Chemistry Letters
- Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
- (2013) Neil C Henderson et al. NATURE MEDICINE
- Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury
- (2013) Marike Marjolijn van Beuge et al. PLoS One
- Integrins as therapeutic targets
- (2012) Simon L. Goodman et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Mechanisms of hepatic fibrogenesis
- (2011) Ursula E. Lee et al. BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
- A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma
- (2011) S O'Day et al. BRITISH JOURNAL OF CANCER
- Integrin inside-out signaling and the immunological synapse
- (2011) Timothy A Springer et al. CURRENT OPINION IN CELL BIOLOGY
- Cross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix
- (2011) J. S. Munger et al. Cold Spring Harbor Perspectives in Biology
- Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing
- (2010) Coert Margadant et al. EMBO REPORTS
- Pirfenidone: an anti-fibrotic therapy for progressive kidney disease
- (2010) Monique E Cho et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The pathogenesis of idiopathic pulmonary fibrosis
- (2010) William R. Coward et al. Therapeutic Advances in Respiratory Disease
- Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis
- (2009) Eleonora Patsenker et al. HEPATOLOGY
- The Integrin Antagonist Cilengitide Activates αVβ3, Disrupts VE-Cadherin Localization at Cell Junctions and Enhances Permeability in Endothelial Cells
- (2009) Gian Carlo Alghisi et al. PLoS One
- Integrin αvβ3-targeted cancer therapy
- (2008) Zhaofei Liu et al. DRUG DEVELOPMENT RESEARCH
- Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression
- (2008) Eleonora Patsenker et al. GASTROENTEROLOGY
- Mechanisms of Hepatic Fibrogenesis
- (2008) Scott L. Friedman GASTROENTEROLOGY
- Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
- (2008) Yury Popov et al. JOURNAL OF HEPATOLOGY
- Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation
- (2007) Gerald S. Horan et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Cellular and molecular mechanisms of fibrosis
- (2007) TA Wynn JOURNAL OF PATHOLOGY
- Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis
- (2007) M. Petersen et al. KIDNEY INTERNATIONAL
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