In Vivo Imaging in Pharmaceutical Development and Its Impact on the 3Rs

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

2015 FDA drug approvals

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Fluorescence guided resection (FGR): A primer for oncology

(2016) Ron R. Allison   Photodiagnosis and Photodynamic Therapy

Discovery of [ 11 C ] MK - 8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors

(2015) Christopher D. Cox et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New developments in optical coherence tomography

(2015) Tigran Kostanyan et al.   CURRENT OPINION IN OPHTHALMOLOGY

Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [11C]MK-8193

(2015) Eric D. Hostetler et al.   MOLECULAR IMAGING AND BIOLOGY

Hepatic Phospholipidosis Is Associated with Altered Hepatobiliary Function as Assessed by Gadoxetate Dynamic Contrast–enhanced Magnetic Resonance Imaging

(2015) Stephen C. Lenhard et al.   TOXICOLOGIC PATHOLOGY

Magnetic resonance imaging assessment of the ventricular system in the brains of adult and juvenile beagle dogs treated with posaconazole IV Solution

(2015) C.D.G. Hines et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A Quantitative Volumetric Micro-Computed Tomography Method to Analyze Lung Tumors in Genetically Engineered Mouse Models

(2015) Brian B. Haines et al.   NEOPLASIA

89Zr-trastuzumab and 89Zr-bevacizumab PET to Evaluate the Effect of the HSP90 Inhibitor NVP-AUY922 in Metastatic Breast Cancer Patients

(2014) S. B. M. Gaykema et al.   CLINICAL CANCER RESEARCH

Radioligand development for molecular imaging of the central nervous system with positron emission tomography

(2014) Michael Honer et al.   DRUG DISCOVERY TODAY

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

(2014) Mark R. Fielden et al.   TOXICOLOGIC PATHOLOGY

Micro-computed tomography imaging and analysis in developmental biology and toxicology

(2013) L. David Wise et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: A head-to-head comparison with alendronate

(2013) Donald S. Williams et al.   BONE

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Advances in Fluorescence and Bioluminescence Imaging

(2012) Takeaki Ozawa et al.   ANALYTICAL CHEMISTRY

Lack of efficacy of L-759274, a novel neurokinin 1 (substance P) receptor antagonist, for the treatment of generalized anxiety disorder

(2012) David Michelson et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies

(2012) James P. B. O'Connor et al.   Nature Reviews Clinical Oncology

The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey

(2012) Sean M. Smith et al.   NEUROPHARMACOLOGY

Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera

(2012) Manfred Kraus et al.   PLoS One

Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting

(2011) Richard Hargreaves et al.   Annals of the New York Academy of Sciences

PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia

(2011) Jan Kehler et al.   CURRENT PHARMACEUTICAL DESIGN

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

Micro-computed tomographic evaluation of fetal skeletal changes induced by all-trans-retinoic acid in rats and rabbits

(2010) L. David Wise et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Novel Luciferase-Based Reporter System to Monitor Activation of ErbB2/Her2/neu Pathway Noninvasively During Radiotherapy

(2010) Frank Wolf et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Cardiovascular Applications of Phase-Contrast MRI

(2009) Monvadi B. Srichai et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Real-time bioluminescence imaging of polycythemia vera development in mice

(2009) Yanhong Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Heat Shock Protein 90 as a Drug Target: Some Like It Hot

(2008) U. Banerji   CLINICAL CANCER RESEARCH

What we can do and what we cannot do with fMRI

(2008) Nikos K. Logothetis   NATURE