The role of integrins in TGFβ activation in the tumour stroma

Is Osteopontin Involved in Cutaneous Fibroblast Activation? Its Hypothetical Role in Scleroderma Pathogenesis

(2017) C. Corallo et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

TGF  Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis

(2016) D. R. Principe et al.   CANCER RESEARCH

Human macrophages induce CD4+ Foxp3+ regulatory T cells via binding and re-release of TGF-β

(2016) Angelika Schmidt et al.   IMMUNOLOGY AND CELL BIOLOGY

Cilengitide with metronomic temozolomide, procarbazine, and standard radiotherapy in patients with glioblastoma and unmethylated MGMT gene promoter in ExCentric, an open-label phase II trial

(2016) Mustafa Khasraw et al.   JOURNAL OF NEURO-ONCOLOGY

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

(2016) Javed Mohammed et al.   NATURE IMMUNOLOGY

Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2

(2016) Robert J. Slack et al.   PHARMACOLOGY

The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer

(2016) Hai Hu et al.   TUMOR BIOLOGY

Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition

(2016) Anai Kothari et al.   Journal of Clinical Medicine

TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis

(2016) Xing Qin et al.   Scientific Reports

αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression

(2015) Anindita Dutta et al.   BIOCHEMICAL JOURNAL

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread

(2015) Ping-Pui Wong et al.   CANCER CELL

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

(2015) R. Hughes et al.   CANCER RESEARCH

Lysyl Oxidase Is Predictive of Unfavorable Outcomes and Essential for Regulation of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma

(2015) Jiye Zhu et al.   DIGESTIVE DISEASES AND SCIENCES

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination

(2015) Takahisa Yamaguchi et al.   Gastric Cancer

Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma

(2015) Xue Hou et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma

(2015) Timothy J Underwood et al.   JOURNAL OF PATHOLOGY

Suppression of TGFβand Angiogenesis by Type VII Collagen in Cutaneous SCC

(2015) V. L. Martins et al.   JNCI-Journal of the National Cancer Institute

Latent TGF-β-binding proteins

(2015) Ian B. Robertson et al.   MATRIX BIOLOGY

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

(2015) Ruchi Malik et al.   TRENDS IN BIOTECHNOLOGY

The role of osteopontin expression in melanoma progression

(2015) Timea Kiss et al.   TUMOR BIOLOGY

MicroRNAs, TGF-β signaling, and the inflammatory microenvironment in cancer

(2015) Lingling Guo et al.   TUMOR BIOLOGY

Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition

(2015) Xiaoping Zhu et al.   Oncotarget

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

Suppression of TGFβand Angiogenesis by Type VII Collagen in Cutaneous SCC

(2015) V. L. Martins et al.   JNCI-Journal of the National Cancer Institute

Polarisation of Tumor-Associated Macrophages toward M2 Phenotype Correlates with Poor Response to Chemoradiation and Reduced Survival in Patients with Locally Advanced Cervical Cancer

(2015) Marco Petrillo et al.   PLoS One

Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors

(2015) Constantin Jotzu et al.   Analytical Cellular Pathology

Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients withKRASwild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial

(2014) E. Élez et al.   ANNALS OF ONCOLOGY

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

(2014) Franco Klingberg et al.   JOURNAL OF CELL BIOLOGY

Therapeutic Targeting of Integrin αvβ6 in Breast Cancer

(2014) Kate M. Moore et al.   JNCI-Journal of the National Cancer Institute

Insidious Changes in Stromal Matrix Fuel Cancer Progression

(2014) Fayth L. Miles et al.   MOLECULAR CANCER RESEARCH

E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin αvβ6 and maintained through TGFβ signalling

(2014) C Eberlein et al.   ONCOGENE

Osteopontin mediates an MZF1–TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer

(2014) C E Weber et al.   ONCOGENE

Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment

(2014) Yorihisa Kotobuki et al.   Pigment Cell & Melanoma Research

Association of the G473A Polymorphism and Expression of Lysyl Oxidase with Breast Cancer Risk and Survival in European Women: A Hospital-Based Case-Control Study

(2014) Andrea Friesenhengst et al.   PLoS One

 1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGF -miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer

(2014) H. H. Truong et al.   Science Signaling

Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells

(2014) Jelena Krstic et al.   TheScientificWorldJOURNAL

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion

(2013) Hildegonda P.H. Naber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of  v 6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence

(2013) M. D. Allen et al.   CLINICAL CANCER RESEARCH

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Integrin β1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts

(2013) Andrew Leask   Advances in Wound Care

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

TGF-  and  v 6 Integrin Act in a Common Pathway to Suppress Pancreatic Cancer Progression

(2012) A. F. Hezel et al.   CANCER RESEARCH

Suppression, subversion and escape: the role of regulatory T cells in cancer progression

(2012) K. Oleinika et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells

(2012) Hongyu Tian et al.   EMBO JOURNAL

Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin  V 8-Mediated Activation of Transforming Growth Factor- 

(2012) T. D. Arnold et al.   JOURNAL OF NEUROSCIENCE

A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis and modulates key biomarkers in vivo

(2012) C Eberlein et al.   ONCOGENE

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

The Metastasis-Associated Extracellular Matrix Protein Osteopontin Forms Transient Structure in Ligand Interaction Sites

(2011) Gerald Platzer et al.   BIOCHEMISTRY

Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by  8 Integrin

(2011) J. H. Tchaicha et al.   CANCER RESEARCH

CCN1/CYR61: the very model of a modern matricellular protein

(2011) Lester F. Lau   CELLULAR AND MOLECULAR LIFE SCIENCES

Switching TGFβ from a tumor suppressor to a tumor promoter

(2011) Gareth J Inman   CURRENT OPINION IN GENETICS & DEVELOPMENT

aV integrins and TGF-β-induced EMT: a circle of regulation

(2011) Fahmy A. Mamuya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis

(2011) A. McNally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin αvβ3, ± dacarbazine in patients with stage IV metastatic melanoma

(2010) Peter Hersey et al.   CANCER

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

Interaction between Periostin and BMP-1 Promotes Proteolytic Activation of Lysyl Oxidase

(2010) Takumi Maruhashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stromal features are predictive of disease mortality in oral cancer patients

(2010) Daniel Marsh et al.   JOURNAL OF PATHOLOGY

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

A mosaic mouse model of astrocytoma identifies αvβ8 integrin as a negative regulator of tumor angiogenesis

(2010) J H Tchaicha et al.   ONCOGENE

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Plasminogen Activator Inhibitor-1 Regulates Integrin αvβ3 Expression and Autocrine Transforming Growth Factor β Signaling

(2009) Benjamin S. Pedroja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice that lack activity of  v 6- and  v 8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

(2009) P. Aluwihare et al.   JOURNAL OF CELL SCIENCE

Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

(2009) Silvia Giampieri et al.   NATURE CELL BIOLOGY

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

Fibulin-5, an integrin-binding matricellular protein: its function in development and disease

(2009) Hiromi Yanagisawa et al.   Journal of Cell Communication and Signaling

Integrins

(2008) Rita Silva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Involvement of Cyr61 in growth, migration and metastasis of prostate cancer cells

(2008) Z-J Sun et al.   BRITISH JOURNAL OF CANCER

Antibody-Mediated Blockade of Integrin  v 6 Inhibits Tumor Progression In vivo by a Transforming Growth Factor- Regulated Mechanism

(2008) L. A. Koopman Van Aarsen et al.   CANCER RESEARCH

 v 6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation

(2008) D. Marsh et al.   CANCER RESEARCH

Transforming Growth Factor  : Tumor Suppressor or Promoter? Are Host Immune Cells the Answer?

(2008) L. Yang et al.   CANCER RESEARCH

Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-  in mammary epithelial cells via a MMP-dependent mechanism

(2008) Y.-H. Lee et al.   CARCINOGENESIS

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Osteopontin Expression Is Required for Myofibroblast Differentiation

(2007) Yair Lenga et al.   CIRCULATION RESEARCH