αvβ8 integrin adhesion and signaling pathways in development, physiology and disease

Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

(2020) Melody G. Campbell et al.   CELL

A potential role for integrins in host cell entry by SARS-CoV-2

(2020) Christian JA Sigrist et al.   ANTIVIRAL RESEARCH

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction

(2019) Thomas D. Arnold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

(2019) Alex A. Pollen et al.   CELL

Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells

(2019) Toshiro Hirai et al.   IMMUNITY

β8 integrin mediates pancreatic cancer cell radiochemoresistance

(2019) Sha Jin et al.   MOLECULAR CANCER RESEARCH

Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy

(2019) Shiping Jiao et al.   CELL

Harnessing region-specific neurovascular signaling to promote germinal matrix vessel maturation and hemorrhage prevention

(2019) Devi Santhosh et al.   Disease Models & Mechanisms

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate

(2019) Vinidhra Mani et al.   SCIENCE

General structural features that regulate integrin affinity revealed by atypical αVβ8

(2019) Jianchuan Wang et al.   Nature Communications

A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma

(2018) Guobin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells

(2018) Zhihua Chen et al.   CANCER RESEARCH

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

(2018) Yan Qin et al.   CELL

Neurovascular Communication during CNS Development

(2018) Isidora Paredes et al.   DEVELOPMENTAL CELL

Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a

(2018) Shweta Tiwary et al.   Scientific Reports

Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-initiating Cells

(2018) Laure Malric et al.   MOLECULAR CANCER RESEARCH

Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension

(2018) Anthony Cormier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation

(2018) Aoife Kelly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

(2018) Stéphanie Liénart et al.   SCIENCE

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression

(2017) P A Guerrero et al.   ONCOGENE

Atypical interactions of integrin αVβ8with pro-TGF-β1

(2017) Jianchuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

(2017) Julie Stockis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β1 Signaling and Tissue Fibrosis

(2017) Kevin K. Kim et al.   Cold Spring Harbor Perspectives in Biology

Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy

(2017) Sam C. Kwiatkowski et al.   PLoS One

Therapy of leptomeningeal metastasis in solid tumors

(2016) F. Mack et al.   CANCER TREATMENT REVIEWS

Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin

(2016) Akio Ozawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage

(2016) Mathilde Boucard-Jourdin et al.   JOURNAL OF IMMUNOLOGY

The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma

(2016) Mujeeburahiman Cheerathodi et al.   MOLECULAR CANCER RESEARCH

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

(2016) T M Fenton et al.   Mucosal Immunology

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

(2016) Javed Mohammed et al.   NATURE IMMUNOLOGY

Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations

(2016) Efthimios Dardiotis et al.   NEUROMOLECULAR MEDICINE

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome

(2016) Michael Weller et al.   Oncotarget

Neuropilin 1 balances  8 integrin-activated TGF  signaling to control sprouting angiogenesis in the brain

(2015) S. Hirota et al.   DEVELOPMENT

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

(2015) John J. Worthington et al.   IMMUNITY

Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter

(2015) Oliver J. Brand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the nascent brain vascular network by neural progenitors

(2015) Devi Santhosh et al.   MECHANISMS OF DEVELOPMENT

Vascularisation of the central nervous system

(2015) Mathew Tata et al.   MECHANISMS OF DEVELOPMENT

Protein Tyrosine Phosphatase-PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells

(2015) Hye Shin Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry

(2015) Tatiana Gianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Integrin activation

(2015) Mark H. Ginsberg   BMB Reports

Structural determinants of integrin β-subunit specificity for latent TGF-β

(2014) Xianchi Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment

(2014) A Savar et al.   ONCOGENE

Selective Targeting of TGF-  Activation to Treat Fibroinflammatory Airway Disease

(2014) S. Minagawa et al.   Science Translational Medicine

αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion

(2013) Steve B. Reyes et al.   MOLECULAR BIOLOGY OF THE CELL

The Changing Integrin Expression and a Role for Integrin β8 in the Chondrogenic Differentiation of Mesenchymal Stem Cells

(2013) Vanessa L. S. LaPointe et al.   PLoS One

 v Integrins in Angiogenesis and Cancer

(2013) S. M. Weis et al.   Cold Spring Harbor Perspectives in Medicine

αvβ6- and αvβ8-Integrins Serve As Interchangeable Receptors for HSV gH/gL to Promote Endocytosis and Activation of Membrane Fusion

(2013) Tatiana Gianni et al.   PLoS Pathogens

Spinophilin: A New Tumor Suppressor at 17q21

(2012) A. Carnero   CURRENT MOLECULAR MEDICINE

Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin  V 8-Mediated Activation of Transforming Growth Factor- 

(2012) T. D. Arnold et al.   JOURNAL OF NEUROSCIENCE

Endothelial Expression of TGFβ Type II Receptor Is Required to Maintain Vascular Integrity during Postnatal Development of the Central Nervous System

(2012) Kathleen R. Allinson et al.   PLoS One

Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST)

(2012) Yanhua Zheng et al.   Chinese Journal of Cancer

Mesangial Cell Integrin αvβ8 Provides Glomerular Endothelial Cell Cytoprotection by Sequestering TGF-β and Regulating PECAM-1

(2011) Shenaz Khan et al.   AMERICAN JOURNAL OF PATHOLOGY

Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by  8 Integrin

(2011) J. H. Tchaicha et al.   CANCER RESEARCH

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

The astrocyte-expressed integrin  v 8 governs blood vessel sprouting in the developing retina

(2011) S. Hirota et al.   DEVELOPMENT

βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8

(2011) Jing Liu et al.   DEVELOPMENTAL BIOLOGY

β8 integrin is essential for neuroblast migration in the rostral migratory stream

(2011) Aaron K. Mobley et al.   GLIA

Interleukin-1β Induces Increased Transcriptional Activation of the Transforming Growth Factor-β-activating Integrin Subunit β8 through Altering Chromatin Architecture

(2011) Jennifer A. Markovics et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

(2011) Hideya Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of αv integrin protein expression in human eyelid and periorbital squamous cell carcinomas

(2011) Adam Hsu et al.   JOURNAL OF CUTANEOUS PATHOLOGY

TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development

(2011) Ha-Long Nguyen et al.   LABORATORY INVESTIGATION

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Transcription of the Transforming Growth Factor β Activating Integrin β8 Subunit Is Regulated by SP3, AP-1, and the p38 Pathway

(2010) Jennifer A. Markovics et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice

(2010) Andrew C. Melton et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

(2010) Etienne Boulter et al.   NATURE CELL BIOLOGY

MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8

(2010) L Fang et al.   ONCOGENE

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Integrins as triggers of Epstein-Barr virus fusion and epithelial cell infection

(2010) Lindsey M. Hutt-Fletcher et al.   Virulence

Reduced Expression of Integrin αvβ8 Is Associated with Brain Arteriovenous Malformation Pathogenesis

(2009) Hua Su et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

(2009) Silvia Peñuelas et al.   CANCER CELL

Cell adhesion and signaling networks in brain neurovascular units

(2009) Joseph H McCarty   CURRENT OPINION IN HEMATOLOGY

Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects

(2009) David S. Harburger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice that lack activity of  v 6- and  v 8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

(2009) P. Aluwihare et al.   JOURNAL OF CELL SCIENCE

 8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain

(2009) A. K. Mobley et al.   JOURNAL OF CELL SCIENCE

Blood vessels form a migratory scaffold in the rostral migratory stream

(2009) Mary C. Whitman et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Intraventricular Hemorrhage in Premature Infants: Mechanism of Disease

(2009) Praveen Ballabh   PEDIATRIC RESEARCH

Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function

(2009) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Ablation of αv Integrins in Epithelial Cells of the Eyelid Skin and Conjunctiva Leads to Squamous Cell Carcinoma

(2008) Joseph H. McCarty et al.   AMERICAN JOURNAL OF PATHOLOGY

TGFβ in Cancer

(2008) Joan Massagué   CELL

 v Integrins Lead the Way for Colorectal Metastases

(2008) J. H. McCarty   CLINICAL CANCER RESEARCH

The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via  v Integrin Ligation

(2008) J. A. Conti et al.   CLINICAL CANCER RESEARCH

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

(2008) Yelena Glinka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

(2007) S. O. Park et al.   BLOOD