Review
Biochemistry & Molecular Biology
Julie Stoufflet, Sylvia Tielens, Laurent Nguyen
Summary: The cerebral cortex, responsible for processing motor and sensory information and shaping personality, relies on cell communication for development and functional organization. Disrupting this cellular crosstalk can lead to neurodevelopmental disorders. This review focuses on how the interaction between migrating cells and their environment influences various aspects of cerebral cortex development.
Article
Oncology
Alison E. Obr, Joseph J. Bulatowicz, Yun-Juan Chang, Virginia Ciliento, Alexander Lemenze, Krystopher Maingrette, Quan Shang, Emily J. Gallagher, Derek LeRoith, Teresa L. Wood
Summary: The reduction of IGF1R expression is associated with the upregulation of pathways necessary for promoting metastasis in breast cancer. Functional analysis reveals that decreased IGF1R signaling leads to a dysregulation of cadherin expression, resulting in reduced cell adhesion.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemical Research Methods
Harris B. Krause, Alexis L. Karls, Megan N. McClean, Pamela K. Kreeger
Summary: Cellular signaling dynamics are sensitive to ligand identity, levels, and temporal patterns. The larger context that cells experience impacts these dynamics, but the reasons for different signaling patterns are not always clear. In this study, ERK signaling in human mammary epithelial cells was compared between well culture and microfluidic culture. The results showed extended ERK activation in well culture and transient activity in microfluidic culture, suggesting that shear stress and autocrine factors played a role in these differences. Growth differentiation factor-15 was identified as a candidate factor that led to extended ERK activation. These findings highlight the importance of considering different contexts in understanding cell signaling dynamics.
Review
Genetics & Heredity
Xin Zhang, Patrick Leavey, Haley Appel, Neoklis Makrides, Seth Blackshaw
Summary: This review provides insights into the recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on comparative single cell multiomic analysis. It discusses the mechanisms by which extrinsic factors trigger transcriptional changes and the core evolutionarily conserved gene regulatory networks that influence retinal progenitor cells and neurogenesis.
TRENDS IN GENETICS
(2023)
Review
Cell Biology
Carl G. Gahmberg, Mikaela Gronholm, Sudarrshan Madhavan
Summary: Most cells express multiple integrins, which can respond to cellular functions and needs through their activation state and regulation of each other. The mechanisms of integrin crosstalk are not fully understood, but they likely involve intracellular signaling pathways shared with other cell surface receptors. Phosphorylation of integrins and key intracellular molecules play a pivotal role in integrin-cytoplasmic interactions and affect integrin activity and crosstalk. Integrin beta-chains are central in regulating crosstalk. Additionally, crosstalk may also occur between integrins and related receptors such as adhesion receptors, growth factor, and SARS-CoV-2 receptors.
Article
Dermatology
Ahmed E. I. Hamouda, Carmen Schalla, Antonio Sechi, Martin Zenke, Rebekka K. Schneider, Thomas Hieronymus
Summary: This study investigates the importance of HGF receptor/Met signaling in the migration of skin-resident Langerhans cells (LCs) and dermal dendritic cells (DCs) towards draining lymph nodes. It demonstrates that Met deficiency impairs podosome formation and gelatin degradation in DCs, leading to inefficient crossing of the basement membrane. HGF-dependent Met activation reduces adhesion and enhances motility of DCs in collagen matrices, while Met signaling has no impact on integrin-independent amoeboid migration.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yongqiang Sha, Beibei Zhang, Liping Chen, Huhai Hong, Qingjia Chi
Summary: Excessive mechanical stress can cause sublethal injury to ACL fibroblasts and hinder their mobility and regeneration. Mechano growth factor (MGF) can mitigate these effects and enhance the physiological behaviors of the cells. This study investigated the effects of MGF on cell mobility and relevant molecular expression in injured ACL fibroblasts. The findings suggest that MGF can improve cell mobility and promote ACL repair, making it a potential treatment approach for ACL rupture in the medical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Kaili Luo, Lei Zhang, Yuan Liao, Hongyu Zhou, Hongying Yang, Min Luo, Chen Qing
Summary: Eps8, overexpressed in most malignant tumors, plays a crucial role in regulating malignant phenotypes and is associated with patient prognosis, making it a potential biomarker for tumor diagnosis and prognosis. Its potential as a therapeutic target for cancer therapy is also explored.
Article
Cell Biology
Yan Zou, Le Pan, Yi Shen, Xiang Wang, Chenxing Huang, Hao Wang, Xuejuan Jin, Chao Yin, Ying Wang, Jianguo Jia, Juying Qian, Yunzeng Zou, Hui Gong, Junbo Ge
Summary: Progressive cardiac fibrosis is accelerated by elevated serum levels of Wnt5a and Wnt11 in hypertension patients, leading to diastolic dysfunction. Pressure overload increases the secretion of Wnt5a and Wnt11 from cardiomyocytes and cardiac fibroblasts, promoting cardiac fibrosis through the activation of FZD5 and EGFR crosstalk.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Shaopeng Yuan, Katherine S. Stewart, Yihao Yang, Merve Deniz Abdusselamoglu, S. Martina Parigi, Tamar Y. Feinberg, Karen Tumaneng, Hanseul Yang, John M. Levorse, Lisa Polak, David Ng, Elaine Fuchs
Summary: This study demonstrates that after activation of the oncogenic RAS gene, cancer stem cells in mice rewire their gene expression and engage in abnormal signaling crosstalk with their tissue microenvironment, driving malignant progression. These findings have important implications for cancer therapeutics.
Review
Biochemical Research Methods
Nunzia Di Maggio, Andrea Banfi
Summary: Recent studies have shown that blood vessels have a regulatory role in bone development and repair, beyond their traditional function of supplying nutrients and oxygen. Type H endothelium, a specialized type of endothelial cells, plays a crucial role in regulating the proliferation and differentiation of osteoblasts and osteoclasts through the secretion of angiocrine signals, facilitating communication between different cell populations in the bone microenvironment. Targeting Type H vessels has become a focus of translational research for bone repair, but there are still unanswered questions about their presence and potential stimulation through pharmacological treatments in non-stereotyped tissues.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Cell Biology
Mireia Perez Verdaguer, Tian Zhang, Joao A. Paulo, Steven Gygi, Simon C. Watkins, Hiroaki Sakurai, Alexander Sorkin
Summary: This study dissects the mechanisms of p38-induced endocytosis of EGFR using a pH-sensitive model, proposing a unifying model of crosstalk between multiple endocytosis pathways. The research reveals that p38-dependent EGFR endocytosis is essential for the interaction with the sigma 2 subunit of clathrin adaptor AP2, and is additive to CME induced by cytokines but constrained to internalizing ligand-free EGFRs due to Grb2 recruitment by ligand-activated EGFRs.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Michael Welsh
Summary: This review discusses the role of the vasculature in regulating the tumor immune cell response and highlights the need for further exploration of the underlying mechanisms. It emphasizes that the vasculature can directly influence immune cell infiltration into tumors and alter the tumor microenvironment, thereby affecting the tumor's immune status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sergi Marco, Matthew Neilson, Madeleine Moore, Arantxa Perez-Garcia, Holly Hall, Louise Mitchell, Sergio Lilla, Giovani R. Blanco, Ann Hedley, Sara Zanivan, Jim C. Norman
Summary: The study explores how EphA2 endosomes are captured at the nuclear surface, triggering signaling cascade in the nucleus, leading to gene transcription and behaviors like cell scattering.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Xiang Tao, Can Chen, Yingxiang Chen, Luoying Zhang, Jiong Hu, Hongjun Yu, Minglu Liang, Qin Fu, Kai Huang
Summary: This study reveals that beta(2)-adrenergic receptor (beta(2)AR) plays a critical role in liver regeneration by interacting with c-met and activating ERK signaling, leading to increased hepatocyte proliferation.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna I. Wolanska, Mark R. Morgan
BIOCHEMICAL SOCIETY TRANSACTIONS
(2015)
Review
Cell Biology
Jonathan D. Humphries, Nikki R. Paul, Martin J. Humphries, Mark R. Morgan
TRENDS IN CELL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. Boettcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini, Donatella Valdembri
NATURE COMMUNICATIONS
(2016)
Article
Oncology
Jo Tod, Christopher J. Hanley, Mark R. Morgan, Marta Rucka, Toby Mellows, Maria-Antoinette Lopez, Philip Kiely, Karwan A. Moutasim, Steven J. Frampton, Durgagauri Sabnis, David R. Fine, Colin Johnson, John F. Marshall, Giorgio Scita, Veronika Jenei, Gareth J. Thomas
JOURNAL OF PATHOLOGY
(2017)
Article
Cell Biology
Mark D. Bass, Rosalind C. Williamson, Robert D. Nunan, Jonathan D. Humphries, Adam Byron, Mark R. Morgan, Paul Martin, Martin J. Humphries
DEVELOPMENTAL CELL
(2011)
Correction
Cell Biology
Mark D. Bass, Rosalind C. Williamson, Robert D. Nunan, Jonathan D. Humphries, Adam Byron, Mark R. Morgan, Paul Martin, Martin J. Humphries
DEVELOPMENTAL CELL
(2012)
Article
Cell Biology
Mark R. Morgan, Hellyeh Hamidi, Mark D. Bass, Stacey Warwood, Christoph Ballestrem, Martin J. Humphries
DEVELOPMENTAL CELL
(2013)
Article
Cell Biology
Guillaume Jacquemet, Mark R. Morgan, Adam Byron, Jonathan D. Humphries, Colin K. Choi, Christopher S. Chen, Patrick T. Caswell, Martin J. Humphries
JOURNAL OF CELL SCIENCE
(2013)
Article
Biochemistry & Molecular Biology
M. R. Morgan, M. Jazayeri, A. G. Ramsay, G. J. Thomas, M. J. Boulanger, I. R. Hart, J. F. Marshall
Article
Chemistry, Multidisciplinary
Christopher J. Hill, Jennifer R. Fleming, Masoumeh Mousavinejad, Rachael Nicholson, Svetomir B. Tzokov, Per A. Bullough, Julius Bogomolovas, Mark R. Morgan, Olga Mayans, Patricia Murray
ADVANCED MATERIALS
(2019)
Article
Biochemistry & Molecular Biology
Colin D. Paul, Kevin Bishop, Alexus Devine, Elliott L. Paine, Jack R. Staunton, Sarah M. Thomas, Joanna R. Thomas, Andrew D. Doyle, Lisa M. Miller Jenkins, Nicole Y. Morgan, Raman Sood, Kandice Tanner
Review
Oncology
Jordan M. Hotz, Joanna R. Thomas, Emily N. Katz, Robert W. Robey, Sachi Horibata, Michael M. Gottesman
Summary: The blood-brain barrier is a network of specialized cells that protect the brain from toxins, allowing only essential molecules to enter. It employs various mechanisms to prevent harmful substances from entering, such as tight junctions and energy-dependent transporters like ABC transporters. Research on ABC transporters in zebrafish is ongoing to understand their role in the BBB and their potential as a model system for further study.
CANCER DRUG RESISTANCE
(2021)
Article
Ophthalmology
Ruchi P. Patel, Joanna R. Thomas, Katherine M. Curt, Christina M. Fitzsimmons, Pedro J. Batista, Susan E. Bates, Michael M. Gottesman, Robert W. Robey
Summary: The combination of romidepsin with mTOR inhibitors was found to effectively induce apoptosis in uveal melanoma cell lines by increasing caspase-3 and PARP cleavage. RNA sequencing analysis revealed significant changes in the apoptosis pathway, with increased pro-apoptotic gene BCL2L11 and decreased anti-apoptotic genes BIRC5 and BCL2L1 at the protein level in response to this combination treatment.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)