Selective Targeting of TGF-  Activation to Treat Fibroinflammatory Airway Disease

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

αVβ3 Integrin Crystal Structures and Their Functional Implications

(2012) Xianchi Dong et al.   BIOCHEMISTRY

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

Mesangial Cell Integrin αvβ8 Provides Glomerular Endothelial Cell Cytoprotection by Sequestering TGF-β and Regulating PECAM-1

(2011) Shenaz Khan et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of integrin affinity on cell surfaces

(2011) Thomas Schürpf et al.   EMBO JOURNAL

Interleukin-1β Induces Increased Transcriptional Activation of the Transforming Growth Factor-β-activating Integrin Subunit β8 through Altering Chromatin Architecture

(2011) Jennifer A. Markovics et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

(2011) Hideya Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiotensin receptor blockade attenuates cigarette smoke–induced lung injury and rescues lung architecture in mice

(2011) Megan Podowski et al.   JOURNAL OF CLINICAL INVESTIGATION

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

P2X7 Receptor and Caspase 1 Activation Are Central to Airway Inflammation Observed after Exposure to Tobacco Smoke

(2011) Suffwan Eltom et al.   PLoS One

Chronic Obstructive Pulmonary Disease Exacerbations in the COPDGene Study: Associated Radiologic Phenotypes

(2011) MeiLan K. Han et al.   RADIOLOGY

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

(2011) Mark J. Anderton et al.   TOXICOLOGIC PATHOLOGY

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD

(2010) Camille Doe et al.   CHEST

Modulation of Integrin Activation by an Entropic Spring in the β-Knee

(2010) Benoit J. Smagghe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

TGF-β Induces Surface LAP Expression on Murine CD4 T Cells Independent of Foxp3 Induction

(2010) Takatoku Oida et al.   PLoS One

Requirement of open headpiece conformation for activation of leukocyte integrin  X 2

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homeostatic Role of Transforming Growth Factor-β in the Oral Cavity and Esophagus of Mice and Its Expression by Mast Cells in These Tissues

(2009) Allison Vitsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrin-Mediated Transforming Growth Factor-β Activation, a Potential Therapeutic Target in Fibrogenic Disorders

(2009) Stephen L. Nishimura   AMERICAN JOURNAL OF PATHOLOGY

Noninvasive and Invasive Pulmonary Function in Mouse Models of Obstructive and Restrictive Respiratory Diseases

(2009) Jeroen A. J. Vanoirbeek et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Integrin αIIbβ3 Activation in Chinese Hamster Ovary Cells and Platelets Increases Clustering Rather than Affinity

(2009) Thomas A. Bunch   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

(2009) Jian-Ping Xiong et al.   JOURNAL OF CELL BIOLOGY

Mice that lack activity of  v 6- and  v 8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

(2009) P. Aluwihare et al.   JOURNAL OF CELL SCIENCE

Linking integrin conformation to function

(2009) J. A. Askari et al.   JOURNAL OF CELL SCIENCE

Imbalances Between Interleukin-1 and Tumor Necrosis Factor Agonists and Antagonists in Stable COPD

(2009) Elizabeth Sapey et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Correlation between serum biomarkers and BODE index in patients with stable COPD

(2009) Shih-Feng LIU et al.   RESPIROLOGY

The Role of Interleukin-1β in Murine Cigarette Smoke–Induced Emphysema and Small Airway Remodeling

(2008) Andrew Churg et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Interleukin-1β Causes Acute Lung Injury via αvβ5 and αvβ6 Integrin–Dependent Mechanisms

(2008) Michael T. Ganter et al.   CIRCULATION RESEARCH