Site-Selective C–H alkylation of Complex Arenes by a Two-Step Aryl Thianthrenation-Reductive Alkylation Sequence

Nickel-Catalyzed Chain-Walking Cross-Electrophile Coupling of Alkyl and Aryl Halides and Olefin Hydroarylation Enabled by Electrochemical Reduction

(2020) Gadde Sathish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

General C(sp2)-C(sp3) Cross-Electrophile Coupling Reactions Enabled by Overcharge Protection of Homogeneous Electrocatalysts

(2020) Blaise L. Truesdell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Chlorides with Primary Alkyl Chlorides

(2020) Seoyoung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Selective C–H Functionalization–Sulfination Sequence to Access Aryl Sulfonamides

(2020) Eva Maria Alvarez et al.   ORGANIC LETTERS

Cross-Electrophile Coupling of Unactivated Alkyl Chlorides

(2020) Holt A. Sakai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions

(2020) Kelsey E. Poremba et al.   ACS Catalysis

Site-selective and versatile aromatic C−H functionalization by thianthrenation

(2019) Florian Berger et al.   NATURE

Late-Stage Functionalization of Peptides and Cyclopeptides Using Organozinc Reagents

(2019) Marcel Leroux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–N Cross-Couplings for Site-Selective Late-Stage Diversification via Aryl Sulfonium Salts

(2019) Pascal S. Engl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination

(2019) Jiakun Li et al.   Nature Chemistry

Nickel-Catalyzed Electrochemical Reductive Relay Cross-Coupling of Alkyl Halides to Aryl Halides

(2019) Ke-Jin Jiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol

(2018) Ren-Jin Tang et al.   JOURNAL OF ORGANIC CHEMISTRY

Beyond Friedel and Crafts: Directed Alkylation of C-H Bonds in Arenes

(2018) Gwilherm Evano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ni-Catalyzed Reductive Coupling of Electron-Rich Aryl Iodides with Tertiary Alkyl Halides

(2018) Xuan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Preparation of α-C-Vinyl/Aryl Glycosides via Nickel-Catalyzed Reductive Coupling of Glycosyl Halides with Vinyl and Aryl Halides

(2018) Jiandong Liu et al.   ORGANIC LETTERS

Electrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides

(2017) Robert J. Perkins et al.   ORGANIC LETTERS

Recent Advances in Nickel Catalysis Enabled by Stoichiometric Metallic Reducing Agents

(2017) Edward Richmond et al.   SYNTHESIS-STUTTGART

Pd-PEPPSI-IHeptCl: A General-Purpose, Highly Reactive Catalyst for the Selective Coupling of Secondary Alkyl Organozincs

(2016) Bruce Atwater et al.   CHEMISTRY-A EUROPEAN JOURNAL

Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile Coupling

(2016) Patricia Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Promoted Atom Transfer Radical Cyclization of Unactivated Alkyl Iodides

(2016) Yangyang Shen et al.   ACS Catalysis

Recent Developments in Negishi Cross-Coupling Reactions

(2016) Diana Haas et al.   ACS Catalysis

Methods and Mechanisms for Cross-Electrophile Coupling of Csp2 Halides with Alkyl Electrophiles

(2015) Daniel J. Weix   ACCOUNTS OF CHEMICAL RESEARCH

Engaging Nonaromatic, Heterocyclic Tosylates in Reductive Cross-Coupling with Aryl and Heteroaryl Bromides

(2015) Gary A. Molander et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Reductive Coupling of Aryl Bromides with Tertiary Alkyl Halides

(2015) Xuan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of C–H Bond Functionalization from Methane to Methodology

(2015) John F. Hartwig   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-catalyzed reductive coupling of alkyl halides with other electrophiles: concept and mechanistic considerations

(2015) Jun Gu et al.   Organic Chemistry Frontiers

Reductive Cross-Coupling Reactions between Two Electrophiles

(2014) Christiane E. I. Knappke et al.   CHEMISTRY-A EUROPEAN JOURNAL

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reductive Cross-Coupling of Nonaromatic, Heterocyclic Bromides with Aryl and Heteroaryl Bromides

(2014) Gary A. Molander et al.   JOURNAL OF ORGANIC CHEMISTRY

Cross-Electrophile Coupling: Principles of Reactivity and Selectivity

(2014) Daniel A. Everson et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides

(2014) Yang Yang et al.   ORGANIC LETTERS

Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

(2013) Thomas H. Marsilje et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism and Selectivity in Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Halides with Alkyl Halides

(2013) Soumik Biswas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increasing small molecule drug developability in sub-optimal chemical space

(2013) Timothy J. Ritchie et al.   MedChemComm

Replacing Conventional Carbon Nucleophiles with Electrophiles: Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides

(2012) Daniel A. Everson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Reductive Coupling of Aryl Halides with Secondary Alkyl Bromides and Allylic Acetate

(2012) Shulin Wang et al.   ORGANIC LETTERS

Photoinduced Ullmann C-N Coupling: Demonstrating the Viability of a Radical Pathway

(2012) S. E. Creutz et al.   SCIENCE

Escape from Flatland 2: complexity and promiscuity

(2012) Frank Lovering   MedChemComm

Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners

(2011) Ranjan Jana et al.   CHEMICAL REVIEWS

Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors

(2011) Eugen F. Mesaros et al.   JOURNAL OF MEDICINAL CHEMISTRY

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides

(2011) Amruta Joshi-Pangu et al.   ORGANIC LETTERS

Direct Method for Carbon-Carbon Bond Formation: The Functional Group Tolerant Cobalt-Catalyzed Alkylation of Aryl Halides

(2010) Muriel Amatore et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Alkyl Halides

(2010) Daniel A. Everson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Secondary Alkyl Halides in Transition-Metal-Catalyzed Cross-Coupling Reactions

(2009) Alena Rudolph et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides

(2009) Chong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zn-Mediated, Pd-Catalyzed Cross-Couplings in Water at Room TemperatureWithoutPrior Formation of Organozinc Reagents

(2009) Arkady Krasovskiy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Cobalt-Catalyzed Cross-Coupling Between Aryl and Alkyl Halides

(2009) Axel Jacobi von Wangelin et al.   SYNLETT

Domino Iron Catalysis: Direct Aryl-Alkyl Cross-Coupling

(2008) Waldemar Maximilian Czaplik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Negishi Cross-Coupling Reactions of In Situ Generated Zinc Reagents with Aryl Chlorides, Bromides, and Triflates

(2008) Shohei Sase et al.   JOURNAL OF ORGANIC CHEMISTRY

Negishi Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Hydrogen Atoms with Organozinc Reagents

(2008) Georg Manolikakes et al.   ORGANIC LETTERS