Antitumoral effects of dovitinib in triple-negative breast cancer are synergized by calcitriol in vivo and in vitro

FGFR3 signaling and function in triple negative breast cancer

(2020) Nicole J. Chew et al.   Cell Communication and Signaling

Identification of synergistic drug combinations using breast cancer patient-derived xenografts

(2020) Tia H. Turner et al.   Scientific Reports

1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells

(2020) Zhirong Jia et al.   Cell Death & Disease

The FGF/FGFR System in Breast Cancer: Oncogenic Features and Therapeutic Perspectives

(2020) Maria Francesca Santolla et al.   Cancers

Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets

(2019) Žiga Skok et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synergistic Antitumorigenic Activity of Calcitriol with Curcumin or Resveratrol is Mediated by Angiogenesis Inhibition in Triple Negative Breast Cancer Xenografts

(2019) Janice García-Quiroz et al.   Cancers

Exploring the binding interaction of calf thymus DNA with lapatinib, a tyrosine kinase inhibitor: multi-spectroscopic techniques combined with molecular docking

(2018) Ke-Ying Chen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Synergistic anti-angiogenic treatment effects by dual FGFR1 and VEGFR1 inhibition in FGFR1-amplified breast cancer

(2018) Kristina Golfmann et al.   ONCOGENE

Receptor Tyrosine Kinase-Targeted Cancer Therapy

(2018) Toshimitsu Yamaoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calcitriol promotes proangiogenic molecules in keratinocytes in a diabetic foot ulcer model

(2017) Valentin Trujillo et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The crossroads of breast cancer progression: insights into the modulation of major signaling pathways

(2017) Fernando Janczur Velloso et al.   OncoTargets and Therapy

Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism

(2016) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial

(2016) A. Pearson et al.   Cancer Discovery

Dovitinib (CHIR258, TKI258): structure, development and preclinical and clinical activity

(2015) Camillo Porta et al.   Future Oncology

Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells

(2015) Mariana Segovia-Mendoza et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanistic Effects of Calcitriol in Cancer Biology

(2015) Lorenza Díaz et al.   Nutrients

Blocking Lipid Synthesis Overcomes Tumor Regrowth and Metastasis after Antiangiogenic Therapy Withdrawal

(2014) Nor Eddine Sounni et al.   Cell Metabolism

The Three Receptor Tyrosine Kinases c-KIT, VEGFR2 and PDGFRα, Closely Spaced at 4q12, Show Increased Protein Expression in Triple-Negative Breast Cancer

(2014) Sara Jansson et al.   PLoS One

Targeting FGFR with Dovitinib (TKI258): Preclinical and Clinical Data in Breast Cancer

(2013) F. Andre et al.   CLINICAL CANCER RESEARCH

Doxorubicin induces atypical NF-κB activation through c-Abl kinase activity in breast cancer cells

(2013) José Esparza-López et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Dovitinib induces mitotic defects and activates the G2DNA damage checkpoint

(2013) Wing Yu Man et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: Implications for tumor angiogenesis

(2013) Janice García-Quiroz et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II

(2012) Brian B. Hasinoff et al.   BIOCHEMICAL PHARMACOLOGY

Population Pharmacokinetic/Pharmacodynamic Modeling to Assist Dosing Schedule Selection for Dovitinib

(2012) Xiaofeng Wang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

1,25(OH)2vitamin D3 enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C2C12 skeletal muscle cells

(2012) Leah A. Garcia et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Fulminant Acneiform Eruptions After Administration of Dovitinib in a Patient With Renal Cell Carcinoma

(2011) Ya-Wen Hsiao et al.   JOURNAL OF CLINICAL ONCOLOGY

Mitotic Catastrophe in Malignant Epithelial Tumors: The Pathologist’s Viewpoint

(2011) Rosario Caruso et al.   ULTRASTRUCTURAL PATHOLOGY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

The Effects of G2-Phase Enrichment and Checkpoint Abrogation on Low-Dose Hyper-Radiosensitivity

(2010) Sarah A. Krueger et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

(2010) N Turner et al.   ONCOGENE

A phase I and pharmacokinetics study of intravenous calcitriol in combination with oral dexamethasone and gefitinib in patients with advanced solid tumors

(2009) Josephia R. Muindi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Calcitriol inhibits Ether-à go-go potassium channel expression and cell proliferation in human breast cancer cells

(2009) Rocío García-Becerra et al.   EXPERIMENTAL CELL RESEARCH

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION