The FGF/FGFR System in Breast Cancer: Oncogenic Features and Therapeutic Perspectives
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Title
The FGF/FGFR System in Breast Cancer: Oncogenic Features and Therapeutic Perspectives
Authors
Keywords
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Journal
Cancers
Volume 12, Issue 10, Pages 3029
Publisher
MDPI AG
Online
2020-10-19
DOI
10.3390/cancers12103029
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Note: Only part of the references are listed.- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- FGFR3 signaling and function in triple negative breast cancer
- (2020) Nicole J. Chew et al. Cell Communication and Signaling
- HER2-positive Advanced Breast Cancer Treatment in 2020
- (2020) Marcelle G Cesca et al. CANCER TREATMENT REVIEWS
- Cancer associated fibroblasts: role in breast cancer and potential as therapeutic targets
- (2020) Rosamaria Lappano et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments
- (2020) Navid Sobhani et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- FGFR4: A promising therapeutic target for breast cancer and other solid tumors
- (2020) Kevin M. Levine et al. PHARMACOLOGY & THERAPEUTICS
- Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer
- (2020) Jamie R. Kutasovic et al. Cancers
- The Landscape of Targeted Therapies in TNBC
- (2020) Elena Vagia et al. Cancers
- Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches
- (2020) Harman Saman et al. Cancers
- Communication in the Cancer Microenvironment as a Target for Therapeutic Interventions
- (2020) Agnieszka Dominiak et al. Cancers
- TIAM1 Upregulation Confers NVP-BEZ235 Resistance to Breast Cancer Cells Through FGFR/STAT3 Pathway
- (2020) Jingjing Qiao et al. BIOCHEMICAL GENETICS
- Fibroblast growth factor‐2, derived from cancer‐associated fibroblasts, stimulates growth and progression of human breast cancer cells via FGFR1 signaling
- (2020) Jinyoung Suh et al. MOLECULAR CARCINOGENESIS
- New Therapeutics in HER2-Positive Advanced Breast Cancer: Towards a Change in Clinical Practices?
- (2020) Essia Mezni et al. Cancers
- Shallow Whole-Genome Sequencing from Plasma Identifies FGFR1 Amplified Breast Cancers and Predicts Overall Survival
- (2020) Chantal Bourrier et al. Cancers
- Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis
- (2020) Ekaterina Ivanova et al. Frontiers in Molecular Biosciences
- GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells Toward Breast Tumor Progression
- (2019) Maria Francesca Santolla et al. Cells
- Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer
- (2019) Luigi Formisano et al. Nature Communications
- Liquid biopsy in breast cancer: A comprehensive review
- (2019) Sahar Alimirzaie et al. CLINICAL GENETICS
- FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer
- (2019) Dominika Piasecka et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins
- (2019) Latko et al. Cells
- PCA-PAM50 improves consistency between breast cancer intrinsic and clinical subtyping reclassifying a subset of luminal A tumors as luminal B
- (2019) Praveen-Kumar Raj-Kumar et al. Scientific Reports
- A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment
- (2019) Jinho Kang et al. Scientific Reports
- Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors
- (2019) Shuyan Dai et al. Cells
- Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells
- (2019) Burcu Emine Celik-Selvi et al. Cells
- Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis
- (2019) Jinglin Zhang et al. Cells
- Fibroblast Growth Factor Receptor Signaling in Skin Cancers
- (2019) Malgorzata Czyz Cells
- Fibroblast Growth Factor Receptor Functions in Glioblastoma
- (2019) Ana Jimenez-Pascual et al. Cells
- Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models
- (2019) Xia Peng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cancer-associated adipocytes: key players in breast cancer progression
- (2019) Qi Wu et al. Journal of Hematology & Oncology
- The Immune Microenvironment of Breast Cancer Progression
- (2019) Tower et al. Cancers
- Targeting FGFR pathway in breast cancer
- (2018) J. Perez-Garcia et al. BREAST
- Effects of FGFR1 Gene Polymorphisms on the Risk of Breast Cancer and FGFR1 Protein Expression
- (2018) Junqiang Wu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs)
- (2018) Rosamaria Lappano et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial–mesenchymal transition, and metastasis in FGFR1-amplified lung cancer
- (2018) Kaixuan Wang et al. ONCOGENE
- Synergistic anti-angiogenic treatment effects by dual FGFR1 and VEGFR1 inhibition in FGFR1-amplified breast cancer
- (2018) Kristina Golfmann et al. ONCOGENE
- Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2
- (2018) Joao Incio et al. Science Translational Medicine
- Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
- (2018) Aurélie S. Cazet et al. Nature Communications
- The LIS1/NDE1 Complex Is Essential for FGF Signaling by Regulating FGF Receptor Intracellular Trafficking
- (2018) Liansheng Liu et al. Cell Reports
- Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer
- (2018) Navid Sobhani et al. Cells
- Sprouty2—a Novel Therapeutic Target in the Nervous System?
- (2018) Barbara Hausott et al. MOLECULAR NEUROBIOLOGY
- Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
- (2018) Sangwon Lee et al. NATURE
- Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
- (2018) Mihriban Karaayvaz et al. Nature Communications
- Effects of FGFR gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-docetaxel-based chemotherapy in breast cancer patients
- (2018) Lu Chen et al. BMC CANCER
- Fibroblast growth factor receptors as treatment targets in clinical oncology
- (2018) Masaru Katoh Nature Reviews Clinical Oncology
- The Yin and Yang of Myeloid Derived Suppressor Cells
- (2018) Snehil Budhwar et al. Frontiers in Immunology
- Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study
- (2017) Lucia Nogova et al. JOURNAL OF CLINICAL ONCOLOGY
- FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells
- (2017) Lukasz Turczyk et al. NEOPLASIA
- Phase 1 study of ODM-203, a selective dual FGFR/VEGFR inhibitor, in patients with advanced solid tumours
- (2016) J. Rodón et al. ANNALS OF ONCOLOGY
- Somatic mutation, copy number and transcriptomic profiles of primary and matched metastatic estrogen receptor-positive breast cancers
- (2016) D. Fumagalli et al. ANNALS OF ONCOLOGY
- Discovering and understanding oncogenic gene fusions through data intensive computational approaches
- (2016) Natasha S. Latysheva et al. NUCLEIC ACIDS RESEARCH
- Blocking the FGF/FGFR system as a ⿿two-compartment⿿ antiangiogenic/antitumor approach in cancer therapy
- (2016) Arianna Giacomini et al. PHARMACOLOGICAL RESEARCH
- Dysregulated FGF signalling in neoplastic disorders
- (2016) Yasmine Tanner et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells
- (2016) Dominika Piasecka et al. Oncotarget
- Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
- (2016) James Campbell et al. Cell Reports
- Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis
- (2016) Celine Lefebvre et al. PLOS MEDICINE
- A phase I, first in human study of FP-1039 (GSK3052230), a novel FGF ligand trap, in patients with advanced solid tumors
- (2015) A. W. Tolcher et al. ANNALS OF ONCOLOGY
- Rationale for targeting fibroblast growth factor receptor signaling in breast cancer
- (2015) Fabrice André et al. BREAST CANCER RESEARCH AND TREATMENT
- Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
- (2015) Giovanni Ciriello et al. CELL
- Fibroblast growth factor family aberrations in cancers: clinical and molecular characteristics
- (2015) A Parish et al. CELL CYCLE
- Targeting multiple tyrosine kinase receptors with Dovitinib blocks invasion and the interaction between tumor cells and cancer-associated fibroblasts in breast cancer
- (2015) Chuanbing Zang et al. CELL CYCLE
- The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing
- (2015) T. Helsten et al. CLINICAL CANCER RESEARCH
- Fibroblast Growth Factor Signaling in the Vasculature
- (2015) Xuehui Yang et al. Current Atherosclerosis Reports
- Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site
- (2015) Vijay K. Ulaganathan et al. NATURE
- Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
- (2015) Chiara Degirolamo et al. NATURE REVIEWS DRUG DISCOVERY
- FGFR1 is an adverse outcome indicator for luminal A breast cancers
- (2015) Yu-Jie Shi et al. Oncotarget
- The Fibroblast Growth Factor signaling pathway
- (2015) David M. Ornitz et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth
- (2015) Kazuyoshi Shiga et al. Cancers
- Abstract 5446: FPA144: A therapeutic antibody for treating patients with gastric cancers bearing FGFR2 gene amplification
- (2015) Abigael T. Gemo et al. CANCER RESEARCH
- Low Prognostic Implication of Fibroblast Growth Factor Family Activation in Triple-negative Breast Cancer Subsets
- (2014) Hee Jin Lee et al. ANNALS OF SURGICAL ONCOLOGY
- Reductions in Myeloid-Derived Suppressor Cells and Lung Metastases using AZD4547 Treatment of a Metastatic Murine Breast Tumor Model
- (2014) Li Liu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis
- (2014) X. Zhang et al. DEVELOPMENT
- COSMIC: exploring the world's knowledge of somatic mutations in human cancer
- (2014) Simon A. Forbes et al. NUCLEIC ACIDS RESEARCH
- Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis
- (2014) Sunday S. Oladipupo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4
- (2014) Julie A. Tucker et al. STRUCTURE
- Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors
- (2013) R. Dienstmann et al. ANNALS OF ONCOLOGY
- Targeting FGFR with Dovitinib (TKI258): Preclinical and Clinical Data in Breast Cancer
- (2013) F. Andre et al. CLINICAL CANCER RESEARCH
- Identification of Targetable FGFR Gene Fusions in Diverse Cancers
- (2013) Yi-Mi Wu et al. Cancer Discovery
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- 621 A Phase I Dose-escalation Study of MFGR1877S, a Human Monoclonal Anti-fibroblast Growth Factor Receptor 3 (FGFR3) Antibody, in Patients (pts) with Advanced Solid Tumors
- (2012) P. ODonnell et al. EUROPEAN JOURNAL OF CANCER
- Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
- (2012) M. J. Potthoff et al. GENES & DEVELOPMENT
- Breast cancer susceptibility associated with rs1219648 (fibroblast growth factor receptor 2) and postmenopausal hormone therapy use in a population-based United States study
- (2012) Shaneda Warren Andersen et al. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
- Macrophages Promote Fibroblast Growth Factor Receptor-Driven Tumor Cell Migration and Invasion in a Cxcr2-Dependent Manner
- (2012) L. R. Bohrer et al. MOLECULAR CANCER RESEARCH
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- Fibroblast Growth Factor Receptor 1 Activation in Mammary Tumor Cells Promotes Macrophage Recruitment in a CX3CL1-Dependent Manner
- (2012) Johanna R. Reed et al. PLoS One
- Fibroblast Growth Factor Receptor Signaling Is Essential for Normal Mammary Gland Development and Stem Cell Function
- (2012) Adam C. Pond et al. STEM CELLS
- Switching addictions between HER2 and FGFR2 in HER2-positive breast tumor cells: FGFR2 as a potential target for salvage after lapatinib failure
- (2011) Koichi Azuma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Interaction between FGFR-2, STAT5, and Progesterone Receptors in Breast Cancer
- (2011) J. P. Cerliani et al. CANCER RESEARCH
- FGFR Signaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both In Vitro and In Vivo
- (2011) Rachel Sharpe et al. CLINICAL CANCER RESEARCH
- Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Antiangiogenesis
- (2011) C. Lieu et al. CLINICAL CANCER RESEARCH
- Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor
- (2011) Elisa Frullanti et al. EUROPEAN JOURNAL OF CANCER PREVENTION
- Mechanisms of FGFR3 actions in endocrine resistant breast cancer
- (2011) D.C. Tomlinson et al. INTERNATIONAL JOURNAL OF CANCER
- Increased expression of fibroblastic growth factor receptor 2 is correlated with poor prognosis in patients with breast cancer
- (2011) Shanshan Sun et al. JOURNAL OF SURGICAL ONCOLOGY
- rs2981582 is associated with FGFR2 expression in normal breast
- (2010) Chang Sun et al. CANCER GENETICS AND CYTOGENETICS
- Potential for Targeting the Fibroblast Growth Factor Receptors in Breast Cancer
- (2010) N. E. Hynes et al. CANCER RESEARCH
- GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling
- (2010) A. Bai et al. CANCER RESEARCH
- FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer
- (2010) N. Turner et al. CANCER RESEARCH
- Biology of FGFRL1, the fifth fibroblast growth factor receptor
- (2010) Beat Trueb CELLULAR AND MOLECULAR LIFE SCIENCES
- Roles of Fibroblast Growth Factor Receptors in Carcinogenesis
- (2010) E. M. Haugsten et al. MOLECULAR CANCER RESEARCH
- Histological types of breast cancer: How special are they?
- (2010) Britta Weigelt et al. Molecular Oncology
- Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets
- (2010) N Turner et al. ONCOGENE
- High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors
- (2009) Laureen S. Ojalvo et al. AMERICAN JOURNAL OF PATHOLOGY
- Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
- (2009) Joel S. Parker et al. JOURNAL OF CLINICAL ONCOLOGY
- FGFR2 Abnormalities Underlie a Spectrum of Bone, Skin, and Cancer Pathologies
- (2009) Masaru Katoh JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma
- (2009) Michael G. Gartside et al. MOLECULAR CANCER RESEARCH
- Gene-Expression Signatures in Breast Cancer
- (2009) Christos Sotiriou et al. NEW ENGLAND JOURNAL OF MEDICINE
- Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
- (2009) S S Kwek et al. ONCOGENE
- De-regulated FGF receptors as therapeutic targets in cancer
- (2009) Victoria Knights et al. PHARMACOLOGY & THERAPEUTICS
- Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase
- (2008) J. Matsui et al. CLINICAL CANCER RESEARCH
- Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling
- (2008) Sara Parsa et al. DEVELOPMENTAL BIOLOGY
- Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer
- (2008) D. Meijer et al. ENDOCRINE-RELATED CANCER
- Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis
- (2008) Sebastián Giulianelli et al. INTERNATIONAL JOURNAL OF CANCER
- Allele-Specific Up-Regulation of FGFR2 Increases Susceptibility to Breast Cancer
- (2008) Kerstin B Meyer et al. PLOS BIOLOGY
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