1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells

Safety and Tolerability of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors in Oncology

(2019) Rashmi R. Shah et al.   DRUG SAFETY

Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer

(2019) Quanfu Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer

(2019) Li Li et al.   CANCER LETTERS

Calcitriol inhibits migration and invasion of RCC cells through suppressing Smad2/3‐, STAT3 and β‐catenin‐ mediated EMT

(2019) Shen Xu et al.   CANCER SCIENCE

Genome-wide identification of transcription factors that are critical to non-small cell lung cancer

(2018) Da-Lin Zhang et al.   CANCER LETTERS

NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 5.2018

(2018) David S. Ettinger et al.   Journal of the National Comprehensive Cancer Network

Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

(2018) Claudia Allemani et al.   LANCET

PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis

(2018) Hsi-Wen Yeh et al.   NATURE CELL BIOLOGY

FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC

(2018) Sisi Cao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

(2018) Rajeswara Rao Arasada et al.   Nature Communications

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

CD146-Mediated Acquisition of Stemness Phenotype Enhances Tumor Invasion and Metastasis after EGFR-TKI Resistance in Lung Cancer

(2018) Fan Zhang et al.   Clinical Respiratory Journal

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

(2018) Tatsunori Nishimura et al.   ONCOGENE

TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway

(2017) Lanfang Wu et al.   FEBS Journal

1,25(OH) 2 D 3 induces regulatory T cell differentiation by influencing the VDR/PLC-γ1/TGF-β1/pathway

(2017) Qiang Zhou et al.   MOLECULAR IMMUNOLOGY

TGF-β1 induces erlotinib resistance in non-small cell lung cancer by down-regulating PTEN

(2016) Hua Shen et al.   BIOMEDICINE & PHARMACOTHERAPY

Expression patterns of Irx genes in the developing chick inner ear

(2016) Sheila Cardeña-Núñez et al.   Brain Structure & Function

Irx4 Marks a Multipotent, Ventricular-Specific Progenitor Cell

(2016) Daryl O. Nelson et al.   STEM CELLS

Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib

(2015) Shinsuke Hashida et al.   CANCER SCIENCE

IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer

(2015) Yi-Nan Liu et al.   Oncotarget

Activation of Vitamin D Receptor Signaling Downregulates the Expression of Nuclear FOXM1 Protein and Suppresses Pancreatic Cancer Cell Stemness

(2014) Z. Li et al.   CLINICAL CANCER RESEARCH

Metformin Sensitizes EGFR-TKI-Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal

(2014) L. Li et al.   CLINICAL CANCER RESEARCH

A novel antagonist to the inhibitors of apoptosis (IAPs) potentiates cell death in EGFR-overexpressing non-small-cell lung cancer cells

(2014) S-H Lee et al.   Cell Death & Disease

Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell-like Properties in Cancer Cells

(2013) K. Shien et al.   CANCER RESEARCH

Genotyping and Genomic Profiling of Non–Small-Cell Lung Cancer: Implications for Current and Future Therapies

(2013) Tianhong Li et al.   JOURNAL OF CLINICAL ONCOLOGY

MiR-134/487b/655 Cluster Regulates TGF- -Induced Epithelial-Mesenchymal Transition and Drug Resistance to Gefitinib by Targeting MAGI2 in Lung Adenocarcinoma Cells

(2013) K. Kitamura et al.   MOLECULAR CANCER THERAPEUTICS

Nanog, a novel prognostic marker for lung cancer

(2013) Yaming Du et al.   SURGICAL ONCOLOGY-OXFORD

Differential response to 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in non-small cell lung cancer cells with distinct oncogene mutations

(2012) Qiuhong Zhang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation

(2012) Jyotirmoi Aich et al.   Nature Communications

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation

(2011) Juan J. Tena et al.   Nature Communications

TGF-  IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

(2010) Z. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Evidence that the Self-Renewal GeneNANOGRegulates Human Tumor Development

(2009) Collene R. Jeter et al.   STEM CELLS

Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a

(2008) Carmen Gloria Feijóo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE