Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome

Memantine Normalizes Several Phenotypic Features in the Ts65Dn Mouse Model of Down Syndrome

(2017) Noemí Rueda et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   JOURNAL OF PINEAL RESEARCH

Emergence of naturally occurring melatonin isomers and their proposed nomenclature

(2012) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities

(2012) Noemí Rueda et al.   NEURAL PLASTICITY

The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats

(2011) Alper Karakaş et al.   BEHAVIOURAL BRAIN RESEARCH

Neurobiological Elements of Cognitive Dysfunction in Down Syndrome: Exploring the Role of APP

(2011) Martha Millan Sanchez et al.   BIOLOGICAL PSYCHIATRY

The use of mouse models to understand and improve cognitive deficits in Down syndrome

(2011) I. Das et al.   Disease Models & Mechanisms

The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-XL antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death

(2011) Noemí Rueda et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Melatonin and Elimination of Kynurenines in Children with Down's Syndrome

(2011) J. Uberos et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

Melatonin improves d-galactose-induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB expression

(2011) Dae Young Yoo et al.   JOURNAL OF PINEAL RESEARCH

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

(2011) Jörg H. Stehle et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

(2011) Sergio A. Rosales-Corral et al.   JOURNAL OF PINEAL RESEARCH

Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

(2011) Xiaolu Sturgeon et al.   MAMMALIAN GENOME

Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

(2011) Renata Bartesaghi et al.   REVIEWS IN THE NEUROSCIENCES

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

(2010) William J. Netzer et al.   PLoS One

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis

(2009) Pallab Maity et al.   JOURNAL OF PINEAL RESEARCH

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease

(2009) James M. Olcese et al.   JOURNAL OF PINEAL RESEARCH

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

(2008) Jason Lockrow et al.   EXPERIMENTAL NEUROLOGY

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

(2008) N. Rueda et al.   NEUROSCIENCE LETTERS

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome

(2007) N RUEDA   BEHAVIOURAL BRAIN RESEARCH

Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2

(2007) Flavia Radogna et al.   JOURNAL OF PINEAL RESEARCH

Melatonin preserves superoxide dismutase activity in hypoglossal motoneurons of adult rats following peripheral nerve injury

(2007) Hung-Ming Chang et al.   JOURNAL OF PINEAL RESEARCH