Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice

Central Artery Stiffness in Hypertension and Aging

(2016) Jay D. Humphrey et al.   CIRCULATION RESEARCH

Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number

(2016) Manja Wachsmuth et al.   PLoS Genetics

Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function

(2016) Kelly L. Stauch et al.   Aging-US

Mitochondrial dysfunction and longevity in animals: Untangling the knot

(2015) Y. Wang et al.   SCIENCE

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

(2014) Jonas Mengel-From et al.   HUMAN GENETICS

Control of mitochondrial integrity in ageing and disease

(2014) R. Szklarczyk et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

(2013) J. L. O. Pohjoismaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress

(2013) Siegfried Hekimi   OncoImmunology

Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding

(2012) Anna Picca et al.   AGE

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis

(2011) Elisabeth Jemt et al.   NUCLEIC ACIDS RESEARCH

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

(2010) John R. Mercer et al.   CIRCULATION RESEARCH

High mitochondrial DNA copy number has detrimental effects in mice

(2010) Emil Ylikallio et al.   HUMAN MOLECULAR GENETICS

Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness

(2010) Charalambos Vlachopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS