Synthesis of CF2H-Substituted Pyrazolines by [3+2] Cycloaddition between CF2HCHN2and Electron-Deficient Alkenes

Preparation of difluoromethylthioethers through difluoromethylation of disulfides using TMS-CF2H

(2016) Joseph L. Howard et al.   CHEMICAL COMMUNICATIONS

Fluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines

(2016) Lucas Mertens et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids

(2016) Dmytro Havrylyuk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

(2016) Long Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorinated diazoalkanes – a versatile class of reagents for the synthesis of fluorinated compounds

(2016) Lucas Mertens et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Oxone-mediated facile access to substituted pyrazoles

(2016) Mitsuhiro Kashiwa et al.   TETRAHEDRON

In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes

(2015) Pavel K. Mykhailiuk   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-Catalyzed Difluoromethylation of Vinyl Bromides, Triflates, Tosylates, and Nonaflates

(2015) Dalu Chang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H

(2015) Sheng-Qing Zhu et al.   Organic Chemistry Frontiers

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

Generation of C2F5CHN2In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes

(2014) Pavel K. Mykhailiuk    CHEMISTRY-A EUROPEAN JOURNAL

Multigram Synthesis of Fluoroalkyl-Substituted Pyrazole-4-carboxylic Acids

(2014) Rustam T. Iminov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2Generated in situ: Optimized Synthesis of Tris(trifluoromethyl)pyrazole

(2014) Evgeniy Y. Slobodyanyuk et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery and Optimization of 1,3,5-Trisubstituted Pyrazolines as Potent and Highly Selective Allosteric Inhibitors of Protein Kinase C-ζ

(2014) Mohammad Abdel-Halim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Difluoromethylene Phosphabetaine as an Equivalent of Difluoromethyl Carbanion

(2014) Vitalij V. Levin et al.   ORGANIC LETTERS

Difluoromethylation and trifluoromethylation reagents derived from tetrafluoroethane β-sultone: Synthesis, reactivity and applications

(2013) Cheng-Pan Zhang et al.   COORDINATION CHEMISTRY REVIEWS

Discovery and Optimization of Pyrazoline Derivatives As Promising Monoamine Oxidase Inhibitors

(2013) Daniela Secci et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure–Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Containing Class of GluN2C/GluN2D Selective Antagonists

(2013) Timothy M. Acker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper(ii) ionic liquid catalyzed cyclization–aromatization of hydrazones with dimethyl acetylenedicarboxylate: a green synthesis of fully substituted pyrazoles

(2013) Shirin Safaei et al.   NEW JOURNAL OF CHEMISTRY

Umpolung of Fluoroform by CF Bond Activation: Direct Difluoromethylation of Lithium Enolates

(2012) Toshiaki Iida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Decarboxylative Allylation of Trifluoroethyl Sulfones and Approach to Difluoromethyl Compounds

(2012) Norio Shibata et al.   ORGANIC LETTERS

Synthesis, biological evaluation and docking studies of novel benzopyranone congeners for their expected activity as anti-inflammatory, analgesic and antipyretic agents

(2009) Amal A.M. Eissa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring: Synthesis and antibacterial activity

(2009) Lin Shan Bai et al.   CHINESE CHEMICAL LETTERS

Pyrazoline bearing benzimidazoles: Search for anticancer agent

(2009) Mohammad Shaharyar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles

(2009) Wei Zhang et al.   ORGANIC LETTERS

Synthesis, Structure, and Antibacterial Activity of Novel 5-Arylpyrazole Derivatives

(2008) Xin-Hua Liu et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors

(2008) M.V. Ramana Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY