Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway

β-arrestin 2 is essential for fluoxetine-mediated promotion of hippocampal neurogenesis in a mouse model of depression

(2021) Chen-xin Li et al.   ACTA PHARMACOLOGICA SINICA

Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3

(2021) Yinquan Fang et al.   CELL DEATH AND DIFFERENTIATION

Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans

(2021) Liam Anuj O'Leary et al.   GLIA

Neuroinflammation in Major Depressive Disorder: A Review of PET Imaging Studies Examining the 18-kDa Translocator Protein

(2021) Davide Gritti et al.   JOURNAL OF AFFECTIVE DISORDERS

Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression

(2020) Qingyu Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Revisiting the validity of the mouse tail suspension test: Systematic review and meta-analysis of the effects of prototypic antidepressants

(2020) Yelena Stukalin et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Inflammatory modulation of fluoxetine use in patients with depression: A systematic review and meta-analysis

(2020) Isabella Barros Almeida et al.   CYTOKINE

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

(2020) He-Yang Zhang et al.   Journal of Neuroinflammation

Dietary quercetin attenuates depressive-like behaviors by inhibiting astrocyte reactivation in response to stress

(2020) Jiajia Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The serotonin 2B receptor is required in neonatal microglia to limit neuroinflammation and sickness behavior in adulthood

(2020) Catherine Béchade et al.   GLIA

Astrocytes-induced neuronal inhibition contributes to depressive-like behaviors during chronic stress

(2020) Tianpao Hao et al.   LIFE SCIENCES

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance

(2020) Weixi Feng et al.   Alzheimers Research & Therapy

Depression and inflammation among children and adolescents: A meta-analysis

(2020) Marlena Colasanto et al.   JOURNAL OF AFFECTIVE DISORDERS

Perisynaptic astrocytes as a potential target for novel antidepressant drugs

(2020) Marcos E. Frizzo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation

(2019) Xiaowei Li et al.   Frontiers in Psychiatry

Therapeutic Potential of Targeting ß-Arrestin

(2019) Richard A. Bond et al.   Frontiers in Pharmacology

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration

(2019) Jared T. Hinkle et al.   MOVEMENT DISORDERS

Ammonium induced dysfunction of 5-HT2B receptor in astrocytes

(2019) Tingting Yue et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocyte–Neuron Interactions in the Striatum: Insights on Identity, Form, and Function

(2019) Baljit S. Khakh   TRENDS IN NEUROSCIENCES

5-HTT independent effects of fluoxetine on neuroplasticity

(2019) Marion J. F. Levy et al.   Scientific Reports

The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression

(2019) Xiaodong Shu et al.   Cell Death & Disease

Astrocyte molecular signatures in Huntington’s disease

(2019) Blanca Diaz-Castro et al.   Science Translational Medicine

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

(2018) Jialei Zhu et al.   CELL DEATH AND DIFFERENTIATION

Astroglial 5-HT2B receptor in mood disorders

(2018) Liang Peng et al.   Expert Review of Neurotherapeutics

Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies

(2018) Cristiano A. Köhler et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Astroglial 5-HT2B receptor in mood disorders

(2018) Liang Peng et al.   Expert Review of Neurotherapeutics

Inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway

(2018) Yahan Liu et al.   Journal of the American Heart Association

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

(2018) Manao Kinoshita et al.   EBioMedicine

Targeting G protein-coupled receptor signalling by blocking G proteins

(2018) Adrian P. Campbell et al.   NATURE REVIEWS DRUG DISCOVERY

Genetics Factors in Major Depression Disease

(2018) Maria Shadrina et al.   Frontiers in Psychiatry

CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination

(2018) Yuan Zhang et al.   MOLECULAR PSYCHIATRY

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs

(2017) M-X Li et al.   MOLECULAR PSYCHIATRY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice

(2016) Yinquan Fang et al.   Journal of Neuroinflammation

Pathogenesis of depression: Insights from human and rodent studies

(2016) C. Ménard et al.   NEUROSCIENCE

Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections

(2015) Marta Kolodziejczak et al.   ACS Chemical Neuroscience

The importance of cytokines and autoantibodies in depression

(2015) Mariana Postal et al.   AUTOIMMUNITY REVIEWS

Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive Gαi/oActivation in Astroglial Cells

(2015) Kazue Hisaoka-Nakashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Structure and function of serotonin G protein-coupled receptors

(2015) John D. McCorvy et al.   PHARMACOLOGY & THERAPEUTICS

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

(2015) Shuying Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects

(2014) Liang Peng et al.   Current Neuropharmacology

Fluoxetine: a case history of its discovery and preclinical development

(2014) Laura Perez-Caballero et al.   Expert Opinion on Drug Discovery

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

5-HT2B receptors are required for serotonin-selective antidepressant actions

(2011) S L Diaz et al.   MOLECULAR PSYCHIATRY

Functional Biomarkers of Depression: Diagnosis, Treatment and Pathophysiology

(2011) Heath D Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition

(2011) R. S. Ray et al.   SCIENCE

The Mouse Forced Swim Test

(2011) Adem Can et al.   Jove-Journal of Visualized Experiments

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation

(2008) Baoman Li et al.   PSYCHOPHARMACOLOGY