Mendelian Randomization Analysis Reveals Causal Effects of Plasma Proteome on Body Composition Traits

Large-scale association analyses identify host factors influencing human gut microbiome composition

(2021) Alexander Kurilshikov et al.   NATURE GENETICS

Revealing the role of the human blood plasma proteome in obesity using genetic drivers

(2021) Shaza B. Zaghlool et al.   Nature Communications

Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates

(2021) Lucy J. Goudswaard et al.   INTERNATIONAL JOURNAL OF OBESITY

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

(2021) Veronika W Skrivankova et al.   BMJ-British Medical Journal

Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet–induced obesity

(2020) Ruhang Tang et al.   Science Advances

Circulating cell adhesion molecules in metabolically healthy obesity

(2020) Arij Mulhem et al.   INTERNATIONAL JOURNAL OF OBESITY

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

(2020) Jie Zheng et al.   NATURE GENETICS

Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass

(2019) Yeonhee Joo et al.   INTERNATIONAL JOURNAL OF OBESITY

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Wnt/β-Catenin Signaling and Obesity

(2018) Na Chen et al.   Frontiers in Physiology

SOX6 rs7117858 polymorphism is associated with osteoporosis and obesity-related phenotypes

(2018) María Correa-Rodríguez et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Co-regulatory networks of human serum proteins link genetics to disease

(2018) Valur Emilsson et al.   SCIENCE

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

(2018) Chen Yao et al.   Nature Communications

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes

(2018) Natalie J. Haywood et al.   Molecular Metabolism

Interpreting findings from Mendelian randomization using the MR-Egger method

(2017) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

(2017) Jack Bowden et al.   STATISTICS IN MEDICINE

Connecting genetic risk to disease end points through the human blood plasma proteome

(2017) Karsten Suhre et al.   Nature Communications

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

(2017) Lasse Folkersen et al.   PLoS Genetics

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

(2017) Gibran Hemani et al.   PLoS Genetics

Efficient strategies for leave-one-out cross validation for genomic best linear unbiased prediction

(2017) Hao Cheng et al.   Journal of Animal Science and Biotechnology

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

The transgenic expression of human follistatin-344 increases skeletal muscle mass in pigs

(2016) Fei Chang et al.   TRANSGENIC RESEARCH

The Use of the Linear Mixed Model in Human Genetics

(2015) Claire Dandine-Roulland et al.   HUMAN HEREDITY

Quantitative variability of 342 plasma proteins in a human twin population

(2015) Y. Liu et al.   Molecular Systems Biology

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

(2015) Momoko Horikoshi et al.   PLoS Genetics

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

The genetics of fat distribution

(2014) Dorit Schleinitz et al.   DIABETOLOGIA

Insulin-like growth factor-I and insulin-like growth factor binding protein-1 are related to cardiovascular disease biomarkers in obese adolescents

(2014) Lorraine E Levitt Katz et al.   PEDIATRIC DIABETES

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

(2013) Ching-Ti Liu et al.   PLoS Genetics

Functional Inactivation of the Genome-Wide Association Study Obesity Gene Neuronal Growth Regulator 1 in Mice Causes a Body Mass Phenotype

(2012) Angela W. S. Lee et al.   PLoS One

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

(2010) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Bioavailable IGF-I Is Associated with Fat-Free Mass Gains after Physical Training in Women

(2010) BRADLEY C. NINDL et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Adipogenesis and WNT signalling

(2008) Constantinos Christodoulides et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)

(2008) David Melzer et al.   PLoS Genetics

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE