Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Oncology
Ann H. Rosendahl, Sofie Bjorner, Maria Ygland Rodstrom, Karin Jirstrom, Signe Borgquist, Christian Ingvar, Michael N. Pollak, Helena Jernstrom
Summary: The study found that circulating levels of IGF-I and IGFBP-3 in breast cancer patients are significantly associated with recurrence-risk, while the correlation with IGFBP-7 levels is weaker. There is a significant interaction between IGFBP-7 levels and recurrence-risk in patients with IGF-IRm positivity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Wojciech Czogala, Wojciech Strojny, Przemyslaw Tomasik, Miroslaw Bik Multanowski, Malgorzata Wojcik, Klaudia Miklusiak, Emil Krzysztofik, Albert Wrobel, Karol Miklusiak, Szymon Skoczen
Summary: This study analyzed the expression of IGF-axis genes and protein concentrations in obese children compared to healthy controls, finding higher expression of IGFBP7 and lower expression of IGF2 and IGFBP1 in obese children. In addition, IGFBP4 concentration was significantly higher in obese children while IGFBP3 showed a rising trend. The study also found correlations between IGFs and IGFBPs with obesity metabolic parameters.
Article
Nutrition & Dietetics
Wojciech Strojny, Wojciech Czogala, Przemyslaw Tomasik, Miroslaw Bik-Multanowski, Malgorzata Wojcik, Klaudia Miklusiak, Karol Miklusiak, Przemyslaw Halubiec, Szymon Skoczen
Summary: The study compared IGF and IGFBP levels in children before and after hematopoietic stem cell transplantation (HSCT) with healthy controls, finding no significant differences in gene expression before and after HSCT, but lower IGF and IGFBP levels in children treated with HSCT.
Article
Endocrinology & Metabolism
Laith M. Haj-Ahmad, Muhannad M. Mahmoud, Nabil W. G. Sweis, Isam Bsisu, Ahmad M. Alghrabli, Alaa M. Ibrahim, Ayman A. Zayed
Summary: The serum IGF-1/IGFBP-3 ratio is a useful marker for the diagnosis of growth hormone deficiency in children. Combining serum IGF-1, IGFBP-3, and the IGF-1/IGFBP-3 ratio can improve the specificity of the diagnosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Kerstin Brismar, Agneta Hilding, Ishrath Ansurudeen, Allan Flyvbjerg, Jan Frystyk, Claes-Goran Ostenson
Summary: Adiponectin, IGFBP-1, and IGFBP-2 are biomarkers of insulin sensitivity. Low levels of adiponectin, IGFBP-1, and IGFBP-2 are independently associated with future abnormal glucose tolerance in both genders. In women, IGFBP-2 is the strongest predictor for prediabetes, while adiponectin is the strongest predictor for type 2 diabetes. In men, IGFBP-1 is the strongest predictor for both prediabetes and type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Anna Sophie L. Kjaer, Rikke Beck Jensen, Jorgen H. Petersen, Allan Linneberg, Line Lund Karhus, Louise Scheutz Henriksen, Trine Holm Johannsen, Katharina M. Main, Andrew R. Hoffman, Anders Juul
Summary: This study found that the levels of IGF-I and IGFBP-3 remain stable throughout an individual's lifetime, thus a single measurement of IGF-I can reliably reflect lifetime exposure. GH therapy has only a slight effect on lifetime exposure to IGF-I and remains below the average exposure in the reference population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Christos Charalambous, James C. Moon, Jeff M. P. Holly, Nishi Chaturvedi, Alun D. Hughes, Gabriella Captur
Summary: The study found that decreasing levels and bioavailability of IGF-I are associated with prolongation of the QTc interval in older individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Wei Wang, Ying Sun, De-Gang Mo, Tai Li, Heng-Chen Yao
Summary: The study found that levels of IGF-1 and IGFBP-2 are associated with risk stratification in ACS patients and can be used as predictive biomarkers. IGF-1 is negatively correlated with TIMI risk levels, while IGFBP-2 is positively correlated with TIMI risk levels.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Emmie N. Upners, Marie Lindhardt Ljubicic, Alexander S. Busch, Margit Bistrup Fischer, Kristian Almstrup, Jorgen H. Petersen, Rikke Beck Jensen, Casper P. Hagen, Anders Juul
Summary: This study evaluated the rapid changes in weight and length, as well as the determinants, in healthy infants and established reference curves for IGF-I and IGFBP-3 in children aged 0 to 1 years. The findings showed a significant association between IGF-I and infant weight gain in girls, but not with longitudinal growth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Charlott Hoerenz, Mandy Vogel, Kerstin Wirkner, Uta Ceglarek, Joachim Thiery, Roland Pfaeffle, Wieland Kiess, Juergen Kratzsch
Summary: This study examines the effects of BMI, contraceptive drugs, and hormone replacement therapy on serum levels of IGF-I and IGFBP-3. The results indicate that obesity and contraceptive drugs can influence the levels of IGF-I and IGFBP-3 in different age groups.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Multidisciplinary
Hui Wang, Ruyue Yu, Meng Wang, Shikun Wang, Xingyu Ouyang, Zhiwen Yan, Shuai Chen, Wei Wang, Fei Wu, Cunyi Fan
Summary: Tendon injury is a common musculoskeletal disorder that limits joint mobility and reduces quality of life. Insulin-like growth factor binding protein 4 (IGFBP-4) has been identified as a potential therapeutic protein for tendon healing. In this study, an electrospun membrane was fabricated using IGFBP4-encapsulated dextran particles and poly (L-lactic acid) (PLLA) solution, which showed excellent cytocompatibility and sustained release of IGFBP-4. In rat Achilles tendon injury model, this scaffold promoted tendon healing at molecular, functional, ultrastructural, and biomechanical levels, potentially through IGF-1/AKT signaling pathway. This study suggests that the IGFBP4-PLLA electrospun membrane holds promise as a therapeutic strategy for tendon injury.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Hideyuki Iwayama, Sachiko Kitagawa, Jyun Sada, Ryosuke Miyamoto, Tomohito Hayakawa, Yoshiyuki Kuroyanagi, Taichiro Muto, Hirokazu Kurahashi, Wataru Ohashi, Junko Takagi, Akihisa Okumura
Summary: The study evaluated the diagnostic accuracy of IGF-1 for screening growth hormone deficiency (GHD) and found that IGF-1 level had poor diagnostic accuracy as a screening test for GHD and should not be used alone for screening. A predictive biomarker for GHD should be developed in the future.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Amrit Bhangoo, Rishi Gupta, Steve P. Shelov, Dennis E. Carey, Siham Accacha, Ilene Fennoy, Lisa Altshuler, Barbara Lowell, Robert Rapaport, Warren Rosenfeld, Phyllis W. Speiser, Svetlana Ten, Michael Rosenbaum
Summary: This study found that IGFBP-1 could identify the presence of insulin resistance in children with a BMI of 1 to 2 SDS, even before known markers of insulin resistance such as elevated triglyceride levels and decreased adiponectin and HDL levels are identified.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ana Isabel Martin, Teresa Priego, Alvaro Moreno-Ruperez, Daniel Gonzalez-Hedstrom, Miriam Granado, Asuncion Lopez-Calderon
Summary: Inflammation triggers a broad response from the neuroendocrine system, affecting all the endocrine axes, particularly the hypothalamic-growth hormone-insulin-like growth factor-1 axis. While the endocrine and metabolic responses to acute inflammation support organism survival, chronic inflammation contributes to catabolic processes leading to muscle wasting and weakness. The inhibition of the hypothalamic-GH-IGF-1 axis plays a role in this mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Preneet Cheema Brar
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2019)
Review
Endocrinology & Metabolism
Shilpa Mehta, Preneet Cheema Brar
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Manish Raisingani, Preneet Cheema Brar
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2019)
Article
Cardiac & Cardiovascular Systems
Preneet Cheema Brar, Anne Chun, Xiazhou Fan, Vivek Jani, Mary Craft, Puneet Bhatla, Shelby Kutty
CARDIOVASCULAR DIABETOLOGY
(2019)
Article
Endocrinology & Metabolism
Preneet Cheema Brar, Ryan Heksch, Kristina Cossen, Diva D. De Leon, Manmohan K. Kamboj, Seth D. Marks, Bess A. Marshall, Ryan Miller, Laura Page, Takara Stanley, Deborah Mitchell, Paul Thornton
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Surgery
Jamie R. Oliver, Kepal N. Patel, Clifford M. Chang, Chelsey K. Baldwin, Preneet C. Brar, Luc G. T. Morris, Babak Givi
Summary: Pediatric medullary thyroid carcinoma has lower rates of lymph node metastases compared to adults. The youngest children have lower risk of lymph node disease, while older children (6-19 years) are at considerable risk for occult metastases. Multifocal tumors increase the risk of metastases in adults, but not in children.
Review
Pediatrics
Esha Brar, Anish Saxena, Claudia Dukler, Fangxi Xu, Deepak Saxena, Preneet Cheema Brar, Yuqi Guo, Xin Li
Summary: The use of e-cigarettes and smoking among adolescents has increased significantly in the past decade, potentially compromising their lung defenses and making them more susceptible to the effects of COVID-19. Studies suggest that smoking may upregulate ACE2 receptors, exacerbating the risk of ARDS in MIS-C.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Ambika P. Ashraf, Bhuvana Sunil, Vaneeta Bamba, Emily Breidbart, Preneet Cheema Brar, Stephanie Chung, Anshu Gupta, Aditi Khokhar, Seema Kumar, Marissa Lightbourne, Manmohan K. Kamboj, Ryan S. Miller, Nivedita Patni, Vandana Raman, Amy S. Shah, Don P. Wilson, Brenda Kohn
Summary: Pediatric endocrinologists play a crucial role in early intervention for dyslipidemia in children, with different treatment strategies needed for various cases. Timely identification and management are extremely important for preventing cardiovascular disease in at-risk youth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Amit Lahoti, Christine Yu, Preneet Cheema Brar, Austin Dalgo, Evgenia Gourgari, Rebecca Harris, Manmohan K. Kamboj, Seth Marks, Radha Nandagopal, Laura Page, Vandana Raman, Danielle G. Reynolds, Kyriakie Sarafoglou, Carrie Terrell, Takara L. Stanley
Summary: This review discusses the necessity and factors affecting the suppression of menstruation and/or ovarian function in adolescent girls, including medical options, efficacy, side effects, and potential negative impacts on bone health. There is a need for further research in this area to better understand the implications of these modalities on bone mass accrual during adolescence.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Preneet Cheema Brar, Shoshana Tell, Shilpa Mehta, Bonita Franklin
Summary: H-DKA is a distinct clinical entity that overlaps with DKA and HHS. Patients with H-DKA present at an average age of 10-13 years, with severe dehydration and renal complications being common features.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Endocrinology & Metabolism
Ana Gutierrez Alvarez, Naomi Yachelevich, Brenda Kohn, Preneet Cheema Brar
Summary: This study reports a case of severe hypertriglyceridemia in a 16-year-old female with FPLD3, treated with measures such as bowel rest, insulin infusion, plasmapheresis, low-fat diet, and fenofibrate. Genetic testing revealed a pathogenic variant in the PPARG gene, and the patient also had type 2 diabetes mellitus (T2DM).
ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Mary Ellen Vajravelu, Joseph M. Kindler, Babette S. Zemel, Abbas Jawad, Dorit Koren, Preneet Brar, Lee J. Brooks, Jessica Reiner, Lorraine E. Levitt Katz
Summary: Among obese adolescents, visceral adiposity is associated with insulin resistance, sleep-disordered breathing, and inflammation.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Nidhi Bansal, Seema Kumar, Preneet Cheema Brar
Summary: Atherosclerosis and cardiovascular risk factors can start in childhood, so it is important to manage dyslipidaemia early. However, many youths with hypercholesterolemia are not receiving appropriate treatment. This review discusses current therapies, drugs under investigation, and potential future directions for the management of paediatric dyslipidaemia to provide new evidence and options for future use.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2023)
Review
Peripheral Vascular Disease
Preneet Cheema Brar
Summary: This review discusses the use of non-invasive measurements, such as arterial stiffness, as surrogate markers for early detection of atherosclerosis and ASCVD risk stratification. These surrogate markers are influenced by age, gender, and ethnicity, and are also affected by the physiological changes during puberty and somatic growth in children and adolescents. Currently, there is no consensus on the ideal measurement method and standardized imaging protocols for youth (<18 years of age). Pediatric normative data are available but not generalizable.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Endocrinology & Metabolism
Merilyn Baby, Jeniece Ilkowitz, Preneet Cheema Brar
Summary: The COVID-19 pandemic has had a significant impact on physical and mental health, potentially leading to an increase in idiopathic central precocious puberty (ICPP) in females. This study retrospectively compared biochemical and radiological parameters of females diagnosed with ICPP during the pandemic and pre-pandemic periods, and examined the associations between BMI, screen time, isolation, stress, and early puberty. The results showed that females diagnosed during the pandemic had higher levels of estradiol and LH, as well as larger ovarian volumes.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)