Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis

(2021) Aliza P. Wingo et al.   NATURE GENETICS

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

LAMP2 deficiency attenuates the neurodegeneration markers induced by HSV-1 infection

(2021) Henrike Kristen et al.   NEUROCHEMISTRY INTERNATIONAL

Autophagy as a Cellular Stress Response Mechanism in the Nervous System

(2020) Nesibe Peker et al.   JOURNAL OF MOLECULAR BIOLOGY

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

(2020) Tosha Williams et al.   Molecular Neurodegeneration

ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

(2020) Haruka Chino et al.   TRENDS IN CELL BIOLOGY

Deficient Chaperone-Mediated Autophagy Promotes Lipid Accumulation in Macrophage

(2020) Lei Qiao et al.   Journal of Cardiovascular Translational Research

Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy

(2020) Li-qun Lu et al.   LIFE SCIENCES

Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

(2020) Eran Schmukler et al.   Cell Death & Disease

Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

(2020) Yuta Ogasawara et al.   Nature Communications

PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

(2020) Priyanka Narayan et al.   Cell Reports

Proteomic Profiling of Mitochondrial-Derived Vesicles in Brain Reveals Enrichment of Respiratory Complex Sub-assemblies and Small TIM Chaperones

(2020) Rosalind F. Roberts et al.   JOURNAL OF PROTEOME RESEARCH

Direct lysosome-based autophagy of lipid droplets in hepatocytes

(2020) Ryan J. Schulze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

(2019) Brandon Farmer et al.   Cells

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

(2019) Paolo Abondio et al.   Genes

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease

(2019) Celia G. Fernandez et al.   Frontiers in Aging Neuroscience

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

(2019) Masaya Tachibana et al.   JOURNAL OF CLINICAL INVESTIGATION

LC3-associated phagocytosis at a glance

(2019) Bradlee L. Heckmann et al.   JOURNAL OF CELL SCIENCE

Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways

(2019) Ilaria Fregno et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation

(2019) Ellen Hubin et al.   FEBS LETTERS

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

(2019) Yu-Wen Alvin Huang et al.   JOURNAL OF NEUROSCIENCE

Protein folding state-dependent sorting at the Golgi apparatus

(2019) Doris Hellerschmied et al.   MOLECULAR BIOLOGY OF THE CELL

LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells

(2019) Francesca De Faveri et al.   Autophagy

The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo

(2019) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina

(2019) Shoji Notomi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

(2018) Paul A. Parcon et al.   Alzheimers & Dementia

Cell culture models of fatty acid overload: Problems and solutions

(2018) Nour Alsabeeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

Regulation of Apolipoprotein E Trafficking by Hepatitis C Virus-Induced Autophagy

(2018) Ja Yeon Kim et al.   JOURNAL OF VIROLOGY

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

(2018) Hari Prasad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

(2018) Ilaria Fregno et al.   EMBO JOURNAL

Combining autophagy-inducing peptides and brefeldin A delivered by perinuclear-localized mesoporous silica nanoparticles: a manipulation strategy for ER-phagy

(2018) Yimin Wang et al.   Nanoscale

LAMP-2B regulates human cardiomyocyte function by mediating autophagosome–lysosome fusion

(2018) Congwu Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical autophagy at ER exit sites regulates procollagen turnover

(2018) Shakib Omari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

(2018) Xunde Xian et al.   eLife

Rubicon: LC3-associated phagocytosis and beyond

(2017) Sing-Wai Wong et al.   FEBS Journal

Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis

(2017) Torbjörn Persson et al.   JOURNAL OF ALZHEIMERS DISEASE

Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes

(2017) Dario Armando Leone et al.   JOURNAL OF IMMUNOLOGY

Mutant Huntingtin Disrupts the Nuclear Pore Complex

(2017) Jonathan C. Grima et al.   NEURON

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Green fluorescent protein-tagged apolipoprotein E: A useful marker for the study of hepatic lipoprotein egress

(2017) Constantin N. Takacs et al.   TRAFFIC

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

(2017) Tal Nuriel et al.   Frontiers in Neuroscience

Transmembrane domain quality control systems operate at the endoplasmic reticulum and Golgi apparatus

(2017) Kit Briant et al.   PLoS One

The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes

(2016) Takashi Nozawa et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

Direct Transcriptional Effects of Apolipoprotein E

(2016) V. Theendakara et al.   JOURNAL OF NEUROSCIENCE

Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy

(2016) Ying Gao et al.   Cell Death & Disease

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes

(2016) Virginie Hubert et al.   Biology Open

Plasma levels of apolipoprotein E and risk of dementia in the general population

(2015) Katrine L. Rasmussen et al.   ANNALS OF NEUROLOGY

Role for Lipid Droplet Biogenesis and Microlipophagy in Adaptation to Lipid Imbalance in Yeast

(2015) Jason D. Vevea et al.   DEVELOPMENTAL CELL

Induced oligomerization targets Golgi proteins for degradation in lysosomes

(2015) Ritika Tewari et al.   MOLECULAR BIOLOGY OF THE CELL

Rubicon swaps autophagy for LAP

(2015) Keith B. Boyle et al.   NATURE CELL BIOLOGY

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Low Plasma ApoE Levels Are Associated with Smaller Hippocampal Size in the Alzheimer's Disease Neuroimaging Initiative Cohort

(2015) Edmond Teng et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Degradation mechanism of a Golgi-retained distal renal tubular acidosis mutant of the kidney anion exchanger 1 in renal cells

(2014) Carmen Y. Chu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin

(2014) Ritika Tewari et al.   MOLECULAR BIOLOGY OF THE CELL

Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases

(2014) Haijian Wu et al.   MOLECULAR NEUROBIOLOGY

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease

(2014) Judes Poirier et al.   NEUROBIOLOGY OF AGING

A Super-Ecliptic, pHluorin-mKate2, Tandem Fluorescent Protein-Tagged Human LC3 for the Monitoring of Mammalian Autophagy

(2014) Isei Tanida et al.   PLoS One

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

The Endosomal Protein-Sorting Receptor Sortilin Has a Role in Trafficking  -1 Antitrypsin

(2012) C. L. Gelling et al.   GENETICS

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

(2011) Lisa von Kleist et al.   CELL

Relieving Autophagy and 4EBP1 from Rapamycin Resistance

(2011) B. Nyfeler et al.   MOLECULAR AND CELLULAR BIOLOGY

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Apolipoprotein E ε4 Prevalence in Alzheimer’s Disease Patients Varies across Global Populations: A Systematic Literature Review and Meta-Analysis

(2010) Sheila Crean et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Glycosylation and Sialylation of Macrophage-derived Human Apolipoprotein E Analyzed by SDS-PAGE and Mass Spectrometry

(2010) Youra Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Role for LAMP-2 in endosomal cholesterol transport

(2009) Alexander Schneede et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection

(2009) Yoshihito Ishida et al.   MOLECULAR BIOLOGY OF THE CELL

Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

(2009) Toshiyuki Nakamura et al.   Molecular Neurodegeneration

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Selective Processing and Metabolism of Disease-Causing Mutant Prion Proteins

(2009) Aarthi Ashok et al.   PLoS Pathogens

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall

(2008) Godfrey S. Getz et al.   JOURNAL OF LIPID RESEARCH

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Apolipoprotein E isoform-specific binding to the low-density lipoprotein receptor

(2007) Taichi Yamamoto et al.   ANALYTICAL BIOCHEMISTRY