Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs

Emerging role of m 6 A modification in cardiovascular diseases

(2022) Liming Peng et al.   CELL BIOLOGY INTERNATIONAL

Insights into N6-methyladenosine and programmed cell death in cancer

(2022) Li Liu et al.   Molecular Cancer

The role of m6A RNA methylation in cancer metabolism

(2022) Yuanyuan An et al.   Molecular Cancer

Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima

(2021) Dan Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

(2021) Ryan A. Flynn et al.   CELL

The cap-specific m6A methyltransferase, PCIF1/CAPAM, is dynamically recruited to the gene promoter in a transcription-dependent manner

(2021) Ai Sugita et al.   JOURNAL OF BIOCHEMISTRY

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

(2021) Sébastien Relier et al.   Nature Communications

Types of nuclear localization signals and mechanisms of protein import into the nucleus

(2021) Juane Lu et al.   Cell Communication and Signaling

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions

(2021) Dan Yu et al.   NUCLEIC ACIDS RESEARCH

Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-β

(2021) Michael A. Tartell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional interplay within the epitranscriptome: Reality or fiction?

(2021) Lina Worpenberg et al.   BIOESSAYS

The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features

(2021) Helena Covelo-Molares et al.   NUCLEIC ACIDS RESEARCH

Inhibition of cytoplasmic cap methylation identifies 5′ TOP mRNAs as recapping targets and reveals recapping sites downstream of native 5′ ends

(2020) Daniel del Valle Morales et al.   NUCLEIC ACIDS RESEARCH

A computational platform for high-throughput analysis of RNA sequences and modifications by mass spectrometry

(2020) Samuel Wein et al.   Nature Communications

The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues

(2020) Radha Raman Pandey et al.   Cell Reports

The origin and evolution of a distinct mechanism of transcription initiation in yeasts

(2020) Zhaolian Lu et al.   GENOME RESEARCH

Identification of unrecognized host factors promoting HIV-1 latency

(2020) Zichong Li et al.   PLoS Pathogens

FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

(2019) Mathieu Ringeard et al.   NATURE

CAPAM: The mRNA Cap Adenosine N6-Methyltransferase

(2019) Victoria H. Cowling   TRENDS IN BIOCHEMICAL SCIENCES

Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates

(2019) Xiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA 5′ ends targeted by cytoplasmic recapping cluster at CAGE tags and select transcripts are alternatively spliced

(2019) Mikaela R. Berger et al.   FEBS LETTERS

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression

(2019) Erdem Sendinc et al.   MOLECULAR CELL

Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro

(2019) Clayton B. Woodcock et al.   Cell Discovery

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

Role for first zinc finger of WT1 in DNA sequence specificity: Denys–Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites

(2017) Dongxue Wang et al.   NUCLEIC ACIDS RESEARCH

Chromosomes Orchestrate Their Own Liberation: Nuclear Envelope Disassembly

(2017) Alfonso Fernández-Álvarez et al.   TRENDS IN CELL BIOLOGY

Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments

(2017) Yuval Malka et al.   Nature Communications

RNA modifications go viral

(2017) Nandan S. Gokhale et al.   PLoS Pathogens

Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

(2017) Ana Tamarkin-Ben-Harush et al.   eLife

Breaching the Barrier—The Nuclear Envelope in Virus Infection

(2016) Thomas C. Mettenleiter   JOURNAL OF MOLECULAR BIOLOGY

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

Methyltransferase-Glo: a universal, bioluminescent and homogenous assay for monitoring all classes of methyltransferases

(2016) Kevin Hsiao et al.   Epigenomics

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins

(2013) Yazan M. Abbas et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

(2010) Yanli Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

(2010) Cheng Lu et al.   STRUCTURE

Ribose 2'-O Methylation of the Vesicular Stomatitis Virus mRNA Cap Precedes and Facilitates Subsequent Guanine-N-7 Methylation by the Large Polymerase Protein

(2009) A. A. Rahmeh et al.   JOURNAL OF VIROLOGY

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

(2008) Guifang Jia et al.   FEBS LETTERS