Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions

m6A RNA methylation regulates the fate of endogenous retroviruses

(2021) Tomasz Chelmicki et al.   NATURE

METTL3 regulates heterochromatin in mouse embryonic stem cells

(2021) Wenqi Xu et al.   NATURE

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

(2021) Jiadong Liu et al.   NATURE

An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine

(2021) Guang Song et al.   Nature Communications

Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA

(2020) Min Zhang et al.   CELL RESEARCH

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

(2020) Jun Liu et al.   SCIENCE

TERT promoter mutations and telomeres during tumorigenesis

(2020) Franziska K Lorbeer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The origin of genomic N6-methyl-deoxyadenosine in mammalian cells

(2020) Michael U. Musheev et al.   Nature Chemical Biology

No evidence for DNA N6-methyladenine in mammals

(2020) Karolos Douvlataniotis et al.   Science Advances

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

New insights into abasic site repair and tolerance

(2020) Petria S. Thompson et al.   DNA REPAIR

METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

(2020) Canfeng Zhang et al.   MOLECULAR CELL

N6-methyladenine in DNA antagonizes SATB1 in early development

(2020) Zheng Li et al.   NATURE

N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2

(2020) Yuan Li et al.   NATURE GENETICS

Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA

(2020) Clayton B Woodcock et al.   NUCLEIC ACIDS RESEARCH

Altered DNA base could play key role in pregnancy

(2020) Elizabeth Pennisi   SCIENCE

Role of Melanin Chemiexcitation in Melanoma Progression and Drug Resistance

(2020) Sanjay Premi   Frontiers in Oncology

Peaking at the right time

(2020) Grant Miura   Nature Chemical Biology

A Role for N6-Methyladenine in DNA Damage Repair

(2020) Xing Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation

(2020) Jie Lan et al.   Nature Communications

New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

(2020) Tiziana Pierini et al.   Acta Neuropathologica Communications

Telomerase reverse transcriptase promoter mutations in thyroid carcinomas: implications in precision oncology—a narrative review

(2020) Xiaotian Yuan et al.   Annals of Translational Medicine

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

(2019) Huilin Huang et al.   NATURE

Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex

(2019) Debamita Paul et al.   NUCLEIC ACIDS RESEARCH

Sequencing abasic sites in DNA at single-nucleotide resolution

(2019) Zheng J. Liu et al.   Nature Chemistry

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intragenomic variability and extended sequence patterns in the mutational signature of ultraviolet light

(2019) Markus Lindberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site

(2019) John R. Horton et al.   Nature Communications

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

(2019) Daniel A. Kuppers et al.   Nature Communications

Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro

(2019) Clayton B. Woodcock et al.   Cell Discovery

Identification of YTH Domain-Containing Proteins as the Readers for N1-Methyladenosine in RNA

(2018) Xiaoxia Dai et al.   ANALYTICAL CHEMISTRY

Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

(2018) Qicong Shen et al.   NATURE

TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma

(2018) Sabine Spiegl-Kreinecker et al.   NEURO-ONCOLOGY

Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins

(2018) Deepak P. Patil et al.   TRENDS IN CELL BIOLOGY

Chemiexcitation and Its Implications for Disease

(2018) Douglas E. Brash et al.   TRENDS IN MOLECULAR MEDICINE

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

(2018) Peng Mao et al.   Nature Communications

N-methyladenine DNA Modification in Glioblastoma

(2018) Qi Xie et al.   CELL

Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers

(2018) Kerryn Elliott et al.   PLoS Genetics

Holliday junction-resolving enzymes-structures and mechanisms

(2017) David M. J. Lilley   FEBS LETTERS

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide

(2017) Shaoru Wang et al.   Chemical Science

Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome

(2017) Fedor Kouzine et al.   Cell Systems

Chemical excitation of electrons: A dark path to melanoma

(2016) Sanjay Premi et al.   DNA REPAIR

DNA methylation on N6-adenine in mammalian embryonic stem cells

(2016) Tao P. Wu et al.   NATURE

RNA modifications: what have we learned and where are we headed?

(2016) Michaela Frye et al.   NATURE REVIEWS GENETICS

Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution

(2016) Peng Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methyltransferase-Glo: a universal, bioluminescent and homogenous assay for monitoring all classes of methyltransferases

(2016) Kevin Hsiao et al.   Epigenomics

Influence of a cis,syn-cyclobutane pyrimidine dimer damage on DNA conformation studied by molecular dynamics simulations

(2015) Alexander Knips et al.   BIOPOLYMERS

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

(2015) Bogdan I. Fedeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis

(2015) Young-Sam Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis

(2015) Young-Sam Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

(2015) Yijin Liu et al.   Cell Reports

TERT promoter mutations and monoallelic activation of TERT in cancer

(2015) F W Huang et al.   Oncogenesis

The Carboxy-Terminal Domain of ROS1 Is Essential for 5-Methylcytosine DNA Glycosylase Activity

(2014) Samuel Hong et al.   JOURNAL OF MOLECULAR BIOLOGY

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

(2014) Bret D. Freudenthal et al.   NATURE

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

Frequency of TERT promoter mutations in primary tumors of the liver

(2014) Alexander Quaas et al.   VIRCHOWS ARCHIV

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

(2013) Marc Remke et al.   ACTA NEUROPATHOLOGICA

Base Pair Opening in a Deoxynucleotide Duplex Containing a cis-syn Thymine Cyclobutane Dimer Lesion

(2013) Belinda B. Wenke et al.   BIOCHEMISTRY

Apurinic/Apyrimidinic Endonuclease 1 Is the Essential Nuclease during Immunoglobulin Class Switch Recombination

(2013) S. Masani et al.   MOLECULAR AND CELLULAR BIOLOGY

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase  

(2013) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Use of knowledge-based restraints inphenix.refineto improve macromolecular refinement at low resolution

(2012) Jeffrey J. Headd et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

A New Generation of Crystallographic Validation Tools for the Protein Data Bank

(2011) Randy J. Read et al.   STRUCTURE

International Cancer Genome Consortium Data Portal--a one-stop shop for cancer genomics data

(2011) J. Zhang et al.   Database-The Journal of Biological Databases and Curation

Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

(2010) Tomoo Ogi et al.   MOLECULAR CELL

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

(2010) Toshiyuki Matsui et al.   NATURE

Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity

(2010) Kei-ichi Takata et al.   NUCLEIC ACIDS RESEARCH

An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase  

(2009) B. van Loon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thymine Dimer-Induced Structural Changes to the DNA Duplex Examined with Reactive Probes†

(2008) Amy E. Rumora et al.   BIOCHEMISTRY

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase   replication fidelity

(2008) Z. F. Pursell et al.   NUCLEIC ACIDS RESEARCH