Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima

An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation

(2020) Shaobo Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

(2020) Jun Liu et al.   SCIENCE

The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila

(2020) Jessica Leismann et al.   EMBO REPORTS

The emerging role of RNA modifications in the regulation of mRNA stability

(2020) Sung Ho Boo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

(2020) Valentina V. Ignatova et al.   GENES & DEVELOPMENT

The origin of genomic N6-methyl-deoxyadenosine in mammalian cells

(2020) Michael U. Musheev et al.   Nature Chemical Biology

No evidence for DNA N6-methyladenine in mammals

(2020) Karolos Douvlataniotis et al.   Science Advances

The 18S rRNA m 6 A methyltransferase METTL 5 promotes mouse embryonic stem cell differentiation

(2020) Ming Xing et al.   EMBO REPORTS

Characterization of SETD3 methyltransferase–mediated protein methionine methylation

(2020) Shaobo Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors

(2020) Guangping Dong et al.   ACS Combinatorial Science

A positive perspective on DNA methylation: regulatory functions of DNA methylation outside of host defense in Gram-positive bacteria

(2020) Taylor M. Nye et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation

(2020) Yang Zeng et al.   GENES & DEVELOPMENT

The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues

(2020) Radha Raman Pandey et al.   Cell Reports

Insight into m 6 A methylation from occurrence to functions

(2020) Wenxiu Ru et al.   Open Biology

Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth

(2020) Bowen Rong et al.   Cell Reports

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression

(2019) Erdem Sendinc et al.   MOLECULAR CELL

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

(2019) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112

(2019) Clayton B. Woodcock et al.   Cell Discovery

Structural insight into human N6amt1–Trm112 complex functioning as a protein methyltransferase

(2019) Wenjing Li et al.   Cell Discovery

The bacterial epigenome

(2019) María A. Sánchez-Romero et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis for the target specificity of actin histidine methyltransferase SETD3

(2019) Shaobo Dai et al.   Nature Communications

From parts lists to functional significance—RNA–protein interactions in gene regulation

(2019) Cornelia Kilchert et al.   Wiley Interdisciplinary Reviews-RNA

The timeline of epigenetic drug discovery: from reality to dreams

(2019) A. Ganesan et al.   Clinical Epigenetics

Interaction of Na+, K+, Mg2+ and Ca2+ counter cations with RNA

(2018) Stefan K. Kolev et al.   Metallomics

Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes

(2018) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor

(2018) Katelyn A. Doxtader et al.   MOLECULAR CELL

Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development

(2018) Mateusz Mendel et al.   MOLECULAR CELL

RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions

(2018) Lilia Ayadi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

N-methyladenine DNA Modification in Glioblastoma

(2018) Qi Xie et al.   CELL

Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase

(2018) Hanxiao Sun et al.   CELL RESEARCH

The Golgi ‘casein kinase’ Fam20C is a genuine ‘phosvitin kinase’ and phosphorylates polyserine stretches devoid of the canonical consensus

(2018) Giorgio Cozza et al.   FEBS Journal

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

The non-specific adenine DNA methyltransferase M.EcoGII

(2017) Iain A Murray et al.   NUCLEIC ACIDS RESEARCH

S -Adenosylmethionine Synthesis Is Regulated by Selective N 6 -Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

(2017) Hiroki Shima et al.   Cell Reports

ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions

(2017) D. Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

DNA methylation on N6-adenine in mammalian embryonic stem cells

(2016) Tao P. Wu et al.   NATURE

RNA modifications: what have we learned and where are we headed?

(2016) Michaela Frye et al.   NATURE REVIEWS GENETICS

Macromolecular Crowding In Vitro , In Vivo , and In Between

(2016) Germán Rivas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Methyltransferase-Glo: a universal, bioluminescent and homogenous assay for monitoring all classes of methyltransferases

(2016) Kevin Hsiao et al.   Epigenomics

A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins

(2015) Alexey G. Kikhney et al.   FEBS LETTERS

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Widespread occurrence ofN6-methyladenosine in bacterial mRNA

(2015) Xin Deng et al.   NUCLEIC ACIDS RESEARCH

The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization

(2013) Alexander Wolf et al.   BIOCHEMICAL JOURNAL

Inhibitory zinc sites in enzymes

(2013) Wolfgang Maret   BIOMETALS

A New Structural Form in the SAM/Metal-Dependent O‑Methyltransferase Family: MycE from the Mycinamicin Biosynthetic Pathway

(2011) David L. Akey et al.   JOURNAL OF MOLECULAR BIOLOGY

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily

(2009) Inmaculada Gómez García et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

(2009) Yanqi Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II

(2008) Yutaka Hirose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure and Mechanism of the Rebeccamycin Sugar 4′-O-Methyltransferase RebM

(2008) Shanteri Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY