Toxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid-biosynthetic pathway

Metabolic survival adaptations of Plasmodium falciparum exposed to sub-lethal doses of fosmidomycin

(2021) Shivendra G. Tewari et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics

(2021) Simon A Cobbold et al.   Molecular Systems Biology

Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism

(2020) Aarti Krishnan et al.   Cell Host & Microbe

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

(2020) Russell P. Swift et al.   PLoS Pathogens

Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma

(2020) Xiaohan Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Strategies and Platforms for Industrial Isoprenoid Engineering

(2020) Georgios Daletos et al.   TRENDS IN BIOTECHNOLOGY

Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication

(2020) Kannan Venugopal et al.   PLoS Pathogens

Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum

(2020) Flavia M. Zimbres et al.   Scientific Reports

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance

(2020) Kumar Sachin Singh et al.   NATURE

Protein O- and C-Glycosylation pathways in Toxoplasma gondii and Plasmodium falciparum

(2019) Giulia Bandini et al.   PARASITOLOGY

Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb

(2019) Gulzar A. Rather et al.   BMC PLANT BIOLOGY

Investigation of the methylerythritol 4-phosphate pathway for microbial terpenoid production through metabolic control analysis

(2019) Daniel Christoph Volke et al.   Microbial Cell Factories

Delayed Death by Plastid Inhibition in Apicomplexan Parasites

(2019) Kit Kennedy et al.   TRENDS IN PARASITOLOGY

Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli

(2018) Kevin W. George et al.   METABOLIC ENGINEERING

On the Origin of Isoprenoid Biosynthesis

(2018) Yosuke Hoshino et al.   MOLECULAR BIOLOGY AND EVOLUTION

Recent Advances in the [Fe–S] Cluster Biogenesis (SUF) Pathway Functional in the Apicoplast of Plasmodium

(2018) Zarna Rajeshkumar Pala et al.   TRENDS IN PARASITOLOGY

Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in Toxoplasma gondii

(2018) Katherine Amberg-Johnson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CRISPR/Cas9 and glycomics tools for Toxoplasma glycobiology

(2018) Elisabet Gas-Pascual et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii plaque assays revisited: Improvements for ultrastructural and quantitative evaluation of lytic parasite growth

(2017) Christoph-Martin Ufermann et al.   EXPERIMENTAL PARASITOLOGY

Enhanced performance of the methylerythritol phosphate pathway by manipulation of redox reactions relevant to IspC, IspG, and IspH

(2017) Jia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli

(2017) Qingyan Li et al.   METABOLIC ENGINEERING

Autophagy-Related Protein ATG18 Regulates Apicoplast Biogenesis in Apicomplexan Parasites

(2017) Priyanka Bansal et al.   mBio

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

(2017) Barbara Castella et al.   Nature Communications

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Gliding Associated Proteins Play Essential Roles during the Formation of the Inner Membrane Complex of Toxoplasma gondii

(2016) Clare R. Harding et al.   PLoS Pathogens

Complex Ancestries of Isoprenoid Synthesis in Dinoflagellates

(2015) Bastian Bentlage et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Novel features of the ISC machinery revealed by characterization of Escherichia coli mutants that survive without iron-sulfur clusters

(2015) Naoyuki Tanaka et al.   MOLECULAR MICROBIOLOGY

Autophagy-Related Protein ATG8 Has a Noncanonical Function for Apicoplast Inheritance in Toxoplasma gondii

(2015) Maude F. Lévêque et al.   mBio

Escherichia coli pyruvate:flavodoxin oxidoreductase, YdbK - regulation of expression and biological roles in protection against oxidative stress

(2015) Takayuki Nakayama et al.   GENES & GENETIC SYSTEMS

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress

(2014) Julien Salamun et al.   FASEB JOURNAL

Protein-protein interaction studies provide evidence for electron transfer from ferredoxin to lipoic acid synthase inToxoplasma gondii

(2014) Nora Frohnecke et al.   FEBS LETTERS

Advantages and disadvantages of conditional systems for characterization of essential genes in Toxoplasma gondii

(2014) ELENA JIMÉNEZ-RUIZ et al.   PARASITOLOGY

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

(2013) Eva Vranová et al.   Annual Review of Plant Biology

Feedback Inhibition of Deoxy-d-xylulose-5-phosphate Synthase Regulates the Methylerythritol 4-Phosphate Pathway

(2013) Aparajita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinatorial Engineering of 1-Deoxy-D-Xylulose 5-Phosphate Pathway Using Cross-Lapping In Vitro Assembly (CLIVA) Method

(2013) Ruiyang Zou et al.   PLoS One

Toxoplasma gondii Relies on Both Host and Parasite Isoprenoids and Can Be Rendered Sensitive to Atorvastatin

(2013) Zhu-Hong Li et al.   PLoS Pathogens

Patterns of Evolutionary Conservation of Essential Genes Correlate with Their Compensability

(2012) Tobias Bergmiller et al.   PLoS Genetics

Apicoplast and Endoplasmic Reticulum Cooperate in Fatty Acid Biosynthesis in Apicomplexan ParasiteToxoplasma gondii

(2011) Srinivasan Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance inToxoplasma gondii

(2011) Sethu C. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations

(2011) Genglin Jin et al.   PLoS One

Fosmidomycin Uptake into Plasmodium and Babesia-Infected Erythrocytes Is Facilitated by Parasite-Induced New Permeability Pathways

(2011) Stefan Baumeister et al.   PLoS One

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

(2011) M. L. Reese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY

Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)

(2010) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioorganometallic mechanism of action, and inhibition, of IspH

(2010) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids

(2010) J. Janouskovec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Gene Replacements inToxoplasma gondiiStrains Deficient for Nonhomologous End Joining

(2009) Barbara A. Fox et al.   EUKARYOTIC CELL

Circular Polymerase Extension Cloning of Complex Gene Libraries and Pathways

(2009) Jiayuan Quan et al.   PLoS One

The Dual Origin ofToxoplasma gondiiN-Glycans†

(2008) Estelle Garénaux et al.   BIOCHEMISTRY