Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb

In vitro mass multiplication and estimation of camptothecin (CPT) in Ophiorrhiza mungos L. var. angustifolia (Thw.) Hook. f.

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De novo transcriptome analyses reveals putative pathway genes involved in biosynthesis and regulation of camptothecin in Nothapodytes nimmoniana (Graham) Mabb.

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A differentially regulated AP2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in Catharanthus roseus

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Metabolite Diversity in Alkaloid Biosynthesis: A Multilane (Diastereomer) Highway for Camptothecin Synthesis in Camptotheca acuminata

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Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants

(2016) Bruno Leite Sampaio et al.   Scientific Reports

Production of natural products through metabolic engineering of Saccharomyces cerevisiae

(2015) Anastasia Krivoruchko et al.   CURRENT OPINION IN BIOTECHNOLOGY

NGS Transcriptomes and Enzyme Inhibitors Unravel Complexity of Picrosides Biosynthesis in Picrorhiza kurroa Royle ex. Benth

(2015) Kirti Shitiz et al.   PLoS One

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila

(2015) Lijie Cui et al.   Scientific Reports

Agrobacterium rhizogenes mediated hairy root induction in endangered Berberis aristata DC.

(2015) Latika Brijwal et al.   SpringerPlus

Pyrenacantha volubilis Wight, (Icacinaceae) a rich source of camptothecine and its derivatives, from the Coromandel Coast forests of India

(2014) Hirenallur Kumarappa Suma et al.   FITOTERAPIA

The seco-iridoid pathway from Catharanthus roseus

(2014) Karel Miettinen et al.   Nature Communications

The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway

(2013) Chun Li et al.   BMC PLANT BIOLOGY

Enzyme Inhibitor Studies Reveal Complex Control of Methyl-D-Erythritol 4-Phosphate (MEP) Pathway Enzyme Expression in Catharanthus roseus

(2013) Mei Han et al.   PLoS One

Efficient plant regeneration via direct organogenesis and Agrobacterium tumefaciens-mediated genetic transformation of Picrorhiza kurroa: an endangered medicinal herb of the alpine Himalayas

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Structure and Dynamics of the Isoprenoid Pathway Network

(2012) Eva Vranová et al.   Molecular Plant

Different Roles of the Mevalonate and Methylerythritol Phosphate Pathways in Cell Growth and Tanshinone Production of Salvia miltiorrhiza Hairy Roots

(2012) Dongfeng Yang et al.   PLoS One

Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport

(2011) Yongzhen Sun et al.   BMC GENOMICS

Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]

(2010) Ravi S Singh et al.   BMC MOLECULAR BIOLOGY

Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae)

(2010) Alessio Valletta et al.   BMC PLANT BIOLOGY

Complete blockage of the mevalonate pathway results in male gametophyte lethality

(2009) M. Suzuki et al.   JOURNAL OF EXPERIMENTAL BOTANY

Opportunities in metabolic engineering to facilitate scalable alkaloid production

(2009) Effendi Leonard et al.   Nature Chemical Biology

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Biosynthetic system of camptothecin, an anticancer plant product

(2008) Mami Yamazaki et al.   JOURNAL OF BIOTECHNOLOGY

Molecular characterization and expression analysis of a new cDNA encoding strictosidine synthase from Ophiorrhiza japonica

(2008) Yang Lu et al.   MOLECULAR BIOLOGY REPORTS

Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida

(2008) Shou-Fang Wu et al.   MOLECULES