Nuclear mRNA Quality Control and Cytoplasmic NMD Are Linked by the Guard Proteins Gbp2 and Hrb1

Cargo transport through the nuclear pore complex at a glance

(2021) Giulia Paci et al.   JOURNAL OF CELL SCIENCE

Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay

(2021) Sebastian Grosse et al.   RNA Biology

RGG-motif containing mRNA export factor Gbp2 acts as a translation repressor

(2021) Gopalakrishna Poornima et al.   RNA Biology

Different Patterns of mRNA Nuclear Retention during Meiotic Prophase in Larch Microsporocytes

(2021) Karolina Majewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recurrent SRSF2 mutations in MDS affect both splicing and NMD

(2020) Mohammad Alinoor Rahman et al.   GENES & DEVELOPMENT

LncRNA AGAP2‐AS1 accelerates cell proliferation, migration, invasion and EMT process in colorectal cancer via regulating miR‐4668‐3p/SRSF1 axis

(2020) Hesheng Li et al.   JOURNAL OF GENE MEDICINE

Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants

(2020) Lucas D Serdar et al.   eLife

A Day in the Life of the Exon Junction Complex

(2020) Lena P. Schlautmann et al.   Biomolecules

SRSF1 regulates exosome microRNA enrichment in human cancer cells

(2020) Yi-Fan Xu et al.   Cell Communication and Signaling

Perspective in Alternative Splicing Coupled to Nonsense-Mediated mRNA Decay

(2020) Juan F. García-Moreno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system

(2020) Sean Paz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Long noncoding RNA SMUL suppresses SMURF2 production-mediated muscle atrophy via nonsense-mediated mRNA decay

(2020) Bolin Cai et al.   Molecular Therapy-Nucleic Acids

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

(2019) Tatsuaki Kurosaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alternative splicing in aging and longevity

(2019) Malini Bhadra et al.   HUMAN GENETICS

microRNA-mediated regulation of splicing factors SRSF1, SRSF2 and hnRNP A1 in context of their alternatively spliced 3′UTRs

(2018) Elżbieta Sokół et al.   EXPERIMENTAL CELL RESEARCH

Splicing mutations in human genetic disorders: examples, detection, and confirmation

(2018) Abramowicz Anna et al.   JOURNAL OF APPLIED GENETICS

Controlling nuclear RNA levels

(2018) Manfred Schmid et al.   NATURE REVIEWS GENETICS

Nuclear retention of mRNAs – quality control, gene regulation and human disease

(2018) Marius Wegener et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression

(2018) Sofia Nasif et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nonsense-Mediated mRNA Decay Begins Where Translation Ends

(2018) Evangelos D. Karousis et al.   Cold Spring Harbor Perspectives in Biology

Protein Synthesis Initiation in Eukaryotic Cells

(2018) William C. Merrick et al.   Cold Spring Harbor Perspectives in Biology

Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1

(2018) Isabel Aznarez et al.   Cell Reports

Surveillance-ready transcription: nuclear RNA decay as a default fate

(2018) Stefan Bresson et al.   Open Biology

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

Quality control of mRNAs at the entry of the nuclear pore: Cooperation in a complex molecular system

(2018) Mohammad Soheilypour et al.   Nucleus

Quality control of mRNAs at the entry of the nuclear pore: Cooperation in a complex molecular system

(2018) Mohammad Soheilypour et al.   Nucleus

Intron retention as a component of regulated gene expression programs

(2017) Aishwarya G. Jacob et al.   HUMAN GENETICS

Cellular differentiation state modulates the mRNA export activity of SR proteins

(2017) Valentina Botti et al.   JOURNAL OF CELL BIOLOGY

Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay

(2017) Teresa Carvalho et al.   JOURNAL OF CELL SCIENCE

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay

(2017) Puneet Gupta et al.   MOLECULAR BIOLOGY REPORTS

Nuclear speckles: molecular organization, biological function and role in disease

(2017) Lukasz Galganski et al.   NUCLEIC ACIDS RESEARCH

High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection

(2017) Alper Celik et al.   RNA

Control of gene expression through the nonsense-mediated RNA decay pathway

(2017) Andrew Nickless et al.   Cell and Bioscience

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export

(2016) Michaela Müller-McNicoll et al.   GENES & DEVELOPMENT

Evolutionarily Conserved Polyadenosine RNA Binding Protein Nab2 Cooperates with Splicing Machinery To Regulate the Fate of Pre-mRNA

(2016) Sharon Soucek et al.   MOLECULAR AND CELLULAR BIOLOGY

Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure

(2016) Maxime Wery et al.   MOLECULAR CELL

mRNA quality control is bypassed for immediate export of stress-responsive transcripts

(2016) Gesa Zander et al.   NATURE

A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs

(2016) Agnieszka M. Gromadzka et al.   NUCLEIC ACIDS RESEARCH

Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways

(2016) Martino Colombo et al.   RNA

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

(2016) Lucas D. Serdar et al.   Nature Communications

The exon junction complex: a lifelong guardian of mRNA fate

(2016) Lauren A. Woodward et al.   Wiley Interdisciplinary Reviews-RNA

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story

(2015) Feng He et al.   Annual Review of Genetics

Co-transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae

(2015) Dominik M. Meinel et al.   BIOESSAYS

RNA mis-splicing in disease

(2015) Marina M. Scotti et al.   NATURE REVIEWS GENETICS

A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells

(2015) Masahiko Ajiro et al.   NUCLEIC ACIDS RESEARCH

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities

(2015) Francesca Fiorini et al.   Nature Communications

Transcriptome Maps of mRNP Biogenesis Factors Define Pre-mRNA Recognition

(2014) Carlo Baejen et al.   MOLECULAR CELL

Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs

(2014) Hugo Bretes et al.   NUCLEIC ACIDS RESEARCH

Inhibition of U4 snRNA in Human Cells Causes the Stable Retention of Polyadenylated Pre-mRNA in the Nucleus

(2014) Anne Hett et al.   PLoS One

Quality control of mRNP biogenesis: Networking at the transcription site

(2014) Andrea B. Eberle et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1

(2014) Alexandra Hackmann et al.   Nature Communications

A Transcriptome-wide Atlas of RNP Composition Reveals Diverse Classes of mRNAs and lncRNAs

(2013) Alex Charles Tuck et al.   CELL

Splicing factor SRSF3 represses the translation of programmed cell death 4 mRNA by associating with the 5′-UTR region

(2013) J Kim et al.   CELL DEATH AND DIFFERENTIATION

Regulation of splicing by SR proteins and SR protein-specific kinases

(2013) Zhihong Zhou et al.   CHROMOSOMA

Removal of Retained Introns Regulates Translation in the Rapidly Developing Gametophyte of Marsilea vestita

(2013) Thomas C. Boothby et al.   DEVELOPMENTAL CELL

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

(2013) B. Loh et al.   GENES & DEVELOPMENT

Monosome Formation during Translation Initiation Requires the Serine/Arginine-Rich Protein Npl3

(2013) C. Baierlein et al.   MOLECULAR AND CELLULAR BIOLOGY

Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing

(2013) Ka-Yiu Edwin Kong et al.   NUCLEIC ACIDS RESEARCH

Recruitment of TREX to the Transcription Machinery by Its Direct Binding to the Phospho-CTD of RNA Polymerase II

(2013) Dominik M. Meinel et al.   PLoS Genetics

Dbp5 — From nuclear export to translation

(2012) Bettina Tieg et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus

(2012) Guramrit Singh et al.   CELL

Co-transcriptional degradation of aberrant pre-mRNA by Xrn2

(2012) Lee Davidson et al.   EMBO JOURNAL

Function of alternative splicing

(2012) Olga Kelemen et al.   GENE

Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins

(2012) Purusharth Rajyaguru et al.   MOLECULAR CELL

Localization of Nucleoporin Tpr to the Nuclear Pore Complex Is Essential for Tpr Mediated Regulation of the Export of Unspliced RNA

(2012) Kalpana Rajanala et al.   PLoS One

Ski2-like RNA helicase structures

(2012) Sean J. Johnson et al.   RNA Biology

Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae

(2012) S. Sayani et al.   RNA

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

(2012) Cyrille Girard et al.   Nature Communications

The intronome of budding yeasts

(2011) Cécile Neuvéglise et al.   COMPTES RENDUS BIOLOGIES

The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits

(2011) Alexandra Hackmann et al.   EMBO REPORTS

Shuttling SR proteins: more than splicing factors

(2011) Laure Twyffels et al.   FEBS Journal

The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes

(2011) S. Chanarat et al.   GENES & DEVELOPMENT

Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3′ end of human genes

(2011) Sandra Bento Martins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

(2011) Yukiko Okada-Katsuhata et al.   NUCLEIC ACIDS RESEARCH

Proofreading and spellchecking: A two-tier strategy for pre-mRNA splicing quality control

(2011) D. E. Egecioglu et al.   RNA

The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway

(2011) J. H. Coyle et al.   RNA

Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay

(2010) Tobias M. Franks et al.   CELL

Decapping Activators in Saccharomyces cerevisiae Act by Multiple Mechanisms

(2010) Tracy Nissan et al.   MOLECULAR CELL

A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination

(2010) Sérgio F. de Almeida et al.   NUCLEIC ACIDS RESEARCH

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

(2010) G. Buchwald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

(2010) D. R. McIlwain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of nuclear mRNA quality control

(2010) Milo B. Fasken et al.   RNA Biology

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

(2010) R. M. Lardelli et al.   RNA

Nuclear export of mRNA

(2010) Murray Stewart   TRENDS IN BIOCHEMICAL SCIENCES

A role for TREX components in the release of spliced mRNA from nuclear speckle domains

(2010) Anusha P. Dias et al.   Nature Communications

An active role for splicing in 3′-end formation

(2010) Harold G. Martinson   Wiley Interdisciplinary Reviews-RNA

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

(2009) A. Yamashita et al.   GENES & DEVELOPMENT

The Shuttling Protein Npl3 Promotes Translation Termination Accuracy in Saccharomyces cerevisiae

(2009) Luis A. Estrella et al.   JOURNAL OF MOLECULAR BIOLOGY

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

(2009) Zbigniew Warkocki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polyadenylation releases mRNA from RNA polymerase II in a process that is licensed by splicing

(2009) F. Rigo et al.   RNA

Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans

(2009) S. Barberan-Soler et al.   RNA

Genome-Wide Identification of Alternative Splice Forms Down-Regulated by Nonsense-Mediated mRNA Decay in Drosophila

(2009) Kasper Daniel Hansen et al.   PLoS Genetics

The SR protein family of splicing factors: master regulators of gene expression

(2008) Jennifer C. Long et al.   BIOCHEMICAL JOURNAL

Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

(2008) Olaf Isken et al.   CELL

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL

P bodies promote stress granule assembly inSaccharomyces cerevisiae

(2008) J. Ross Buchan et al.   JOURNAL OF CELL BIOLOGY

Widespread Impact of Nonsense-Mediated mRNA Decay on the Yeast Intronome

(2008) Shakir Sayani et al.   MOLECULAR CELL

A Single SR-like Protein, Npl3, Promotes Pre-mRNA Splicing in Budding Yeast

(2008) Tracy L. Kress et al.   MOLECULAR CELL

Translational control of intron splicing in eukaryotes

(2008) Olivier Jaillon et al.   NATURE

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unphosphorylated SR-Like Protein Npl3 Stimulates RNA Polymerase II Elongation

(2008) Jessica L. Dermody et al.   PLoS One

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

(2008) E. Huntzinger et al.   RNA

An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes

(2008) Michal Skružný et al.   PLOS BIOLOGY

The dynamics of pre-mRNAs and poly(A)+ RNA at speckles in living cells revealed by iFRAP studies

(2007) Yo Ishihama et al.   EXPERIMENTAL CELL RESEARCH