The exon junction complex: a lifelong guardian of mRNA fate

The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay

(2016) Eleen Y. Shum et al.   CELL

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export

(2016) Michaela Müller-McNicoll et al.   GENES & DEVELOPMENT

Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing

(2016) Tassa Saldi et al.   JOURNAL OF MOLECULAR BIOLOGY

Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain

(2016) Louis-Jan Pilaz et al.   NEURON

A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs

(2016) Agnieszka M. Gromadzka et al.   NUCLEIC ACIDS RESEARCH

mRNA biogenesis-related helicase eIF4AIII from Arabidopsis thaliana is an important factor for abiotic stress adaptation

(2016) Cecilia Pascuan et al.   PLANT CELL REPORTS

A New Mutation, hap1-2, Reveals a C Terminal Domain Function in AtMago Protein and Its Biological Effects in Male Gametophyte Development in Arabidopsis thaliana

(2016) Kevin Cilano et al.   PLoS One

Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins

(2016) Christian Hauer et al.   Cell Reports

Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

(2016) Evangelos D. Karousis et al.   Wiley Interdisciplinary Reviews-RNA

The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion

(2015) Guramrit Singh et al.   Annual Review of Biochemistry

Control of mRNA Stability in Fungi by NMD, EJC and CBC Factors Through 3′UTR Introns

(2015) Ying Zhang et al.   GENETICS

Rbm8a Haploinsufficiency Disrupts Embryonic Cortical Development Resulting in Microcephaly

(2015) H. Mao et al.   JOURNAL OF NEUROSCIENCE

Antisense oligonucleotide–directed inhibition of nonsense-mediated mRNA decay

(2015) Tomoki T Nomakuchi et al.   NATURE BIOTECHNOLOGY

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The structure of the SOLE element of oskar mRNA

(2015) B. Simon et al.   RNA

Control of mRNA Stability in Fungi by NMD, EJC and CBC Factors Through 3′UTR Introns

(2015) Ying Zhang et al.   GENETICS

The exon junction complex is required for definition and excision of neighboring introns inDrosophila

(2014) Rippei Hayashi et al.   GENES & DEVELOPMENT

The exon junction complex controls transposable element activity by ensuring faithful splicing of thepiwitranscript

(2014) Colin D. Malone et al.   GENES & DEVELOPMENT

Expression, Purification, and Identification of Associated Proteins of the Full-length hCDK12/CyclinK Complex

(2014) Bartlomiej Bartkowiak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RNA Helicase DHX34 Activates NMD by Promoting a Transition from the Surveillance to the Decay-Inducing Complex

(2014) Nele Hug et al.   Cell Reports

The EJC Binding and Dissociating Activity of PYM Is Regulated in Drosophila

(2014) Sanjay Ghosh et al.   PLoS Genetics

A Noncoding Expansion in EIF4A3 Causes Richieri-Costa-Pereira Syndrome, a Craniofacial Disorder Associated with Limb Defects

(2013) Francine P. Favaro et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes

(2013) Debra L. Silver et al.   DEVELOPMENTAL BIOLOGY

Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay

(2013) Akio Yamashita   GENES TO CELLS

Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway

(2013) Alexandre Jose Christino Quaresma et al.   MOLECULAR BIOLOGY OF THE CELL

Nonsense-mediated mRNA decay: Inter-individual variability and human disease

(2013) Lam Son Nguyen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain

(2013) G. Buchwald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EJC core component MLN51 interacts with eIF3 and activates translation

(2013) P.-E. Chazal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactome of Two Diverse RNA Granules Links mRNA Localization to Translational Repression in Neurons

(2013) Renate Fritzsche et al.   Cell Reports

Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy

(2013) Inna Shcherbakova et al.   Cell Reports

Trafficking of mRNAs containing ALREX-promoting elements through nuclear speckles

(2013) Abdalla Akef et al.   Nucleus

The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus

(2012) Guramrit Singh et al.   CELL

Eif4a3 is required for accurate splicing of the Xenopus laevis ryanodine receptor pre-mRNA

(2012) Tomomi Haremaki et al.   DEVELOPMENTAL BIOLOGY

Proximal microdeletions and microduplications of 1q21.1 contribute to variable abnormal phenotypes

(2012) Jill A Rosenfeld et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The RNA polymerase II CTD coordinates transcription and RNA processing

(2012) J.-P. Hsin et al.   GENES & DEVELOPMENT

Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome

(2012) Cornelis A Albers et al.   NATURE GENETICS

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

(2012) Jérôme Saulière et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA

(2012) Sanjay Ghosh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

(2012) Isabelle Barbosa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay

(2012) A. Alexandrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly

(2012) Anna-Lena Steckelberg et al.   Cell Reports

Proteins Associated with the Exon Junction Complex Also Control the Alternative Splicing of Apoptotic Regulators

(2011) L. Michelle et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes

(2011) Can Cenik et al.   PLoS Genetics

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

(2011) María S. Domínguez-Sánchez et al.   PLoS Genetics

The nosology of Richieri-Costa/Guion-Almeida syndrome(s)

(2010) Marco Castori et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Richieri-Costa-Pereira syndrome: A unique acrofacial dysostosis type. An overview of the Brazilian cases

(2010) Francine Pinheiro Favaro et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The Exon Junction Complex Controls the Splicing of mapk and Other Long Intron-Containing Transcripts in Drosophila

(2010) Dariel Ashton-Beaucage et al.   CELL

Exon Junction Complex Subunits Are Required to Splice Drosophila MAP Kinase, a Large Heterochromatic Gene

(2010) Jean-Yves Roignant et al.   CELL

Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe

(2010) Jikai Wen et al.   EMBO JOURNAL

Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs

(2010) James R Boyne et al.   EMBO JOURNAL

Localization, anchoring and translational control ofoskar,gurken,bicoidandnanosmRNA during Drosophila oogenesis

(2010) Jan-Michael Kugler et al.   FLY

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

(2010) I. Kashima et al.   GENES & DEVELOPMENT

Nuclear Import Mechanism of the EJC Component Mago-Y14 Revealed by Structural Studies of Importin 13

(2010) Fulvia Bono et al.   MOLECULAR CELL

The exon junction complex component Magoh controls brain size by regulating neural stem cell division

(2010) Debra L Silver et al.   NATURE NEUROSCIENCE

The exon junction complex differentially marks spliced junctions

(2010) Jérôme Saulière et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

(2010) G. Buchwald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for TREX components in the release of spliced mRNA from nuclear speckle domains

(2010) Anusha P. Dias et al.   Nature Communications

Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation

(2009) Assen Marintchev et al.   CELL

Disassembly of Exon Junction Complexes by PYM

(2009) Niels H. Gehring et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones

(2009) X.-Y. Zhong et al.   GENES & DEVELOPMENT

Uncoupling of hTREX demonstrates that UAP56 and hTHO-complex recruitment onto herpesvirus saimiri intronless transcripts is required for replication

(2009) K. J. Colgan et al.   JOURNAL OF GENERAL VIROLOGY

Mago Nashi is involved in meristem organization, pollen formation, and seed development in Arabidopsis

(2009) Nam-Il Park et al.   PLANT SCIENCE

The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay

(2009) Niels H. Gehring et al.   PLOS BIOLOGY

Genome-Wide Identification of Alternative Splice Forms Down-Regulated by Nonsense-Mediated mRNA Decay in Drosophila

(2009) Kasper Daniel Hansen et al.   PLoS Genetics

Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

(2008) Olaf Isken et al.   CELL

SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs

(2008) Xiaoju Max Ma et al.   CELL

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Isolation of an active step I spliceosome and composition of its RNP core

(2008) Sergey Bessonov et al.   NATURE

Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities

(2008) Nicola Brunetti-Pierri et al.   NATURE GENETICS

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recurrent Rearrangements of Chromosome 1q21.1 and Variable Pediatric Phenotypes

(2008) Heather C. Mefford et al.   NEW ENGLAND JOURNAL OF MEDICINE

Flexibility in the site of exon junction complex deposition revealed by functional group and RNA secondary structure alterations in the splicing substrate

(2008) D. M. Mishler et al.   RNA

Mechanism of ATP turnover inhibition in the EJC

(2008) K. H. Nielsen et al.   RNA

Coupling and coordination in gene expression processes: a systems biology view

(2007) Suzanne Komili et al.   NATURE REVIEWS GENETICS