Therapeutic CFTR Correction Normalizes Systemic and Lung-Specific S1P Level Alterations Associated with Heart Failure

Ceramide and sphingosine-1 phosphate in COPD lungs

(2021) Evgeny V Berdyshev et al.   THORAX

Plasma S1P (Sphingosine-1-Phosphate) Links to Hypertension and Biomarkers of Inflammation and Cardiovascular Disease: Findings From a Translational Investigation

(2021) Amra Jujic et al.   HYPERTENSION

Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts

(2021) SiddabasaveGowda B. Gowda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Spns2 Transporter Contributes to the Accumulation of S1P in Cystic Fibrosis Human Bronchial Epithelial Cells

(2021) Aida Zulueta et al.   Biomedicines

Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation

(2020) Guadalupe Ortiz-Muñoz et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition?

(2020) Emina Halilbasic et al.   Nutrients

Heterozygous Cystic Fibrosis Transmembrane Regulator Gene Missense Variants Are Associated With Worse Cardiac Function in Patients With Duchenne Muscular Dystrophy

(2020) Xuan Jiang et al.   Journal of the American Heart Association

Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke

(2020) Jia Liu et al.   Frontiers in Neurology

T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis

(2019) Nicholas Don-Doncow et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke

(2019) Angélica Salas-Perdomo et al.   Scientific Reports

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice

(2019) Hideru Obinata et al.   JOURNAL OF LIPID RESEARCH

Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum

(2019) Abigail J. Marklew et al.   Scientific Reports

The emerging alliance of sphingosine-1-phosphate signalling and immune cells: from basic mechanisms to implications in hypertension

(2018) Nicholas Don-Doncow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Macrophages: Their role, activation and polarization in pulmonary diseases

(2018) Shweta Arora et al.   IMMUNOBIOLOGY

A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells

(2018) Gao Yi et al.   INFLAMMATION RESEARCH

Sphingosine 1-Phosphate and Atherosclerosis

(2018) Makoto Kurano et al.   Journal of Atherosclerosis and Thrombosis

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells

(2018) Naoki Kobayashi et al.   Scientific Reports

CFTR dysfunction in cystic fibrosis and chronic obstructive pulmonary disease

(2018) Elena Fernandez Fernandez et al.   Expert Review of Respiratory Medicine

CD86 Expression by Monocytes Influences an Immunomodulatory Profile in Asymptomatic Patients with Chronic Chagas Disease

(2018) Bruna F. Pinto et al.   Frontiers in Immunology

S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and PressureNovelty and Significance

(2017) Anna Cantalupo et al.   HYPERTENSION

Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease

(2017) Amin Polzin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?

(2017) Nigel J. Pyne et al.   TRENDS IN MOLECULAR MEDICINE

Different Regulation of Interleukin-1 Production and Activity in Monocytes and Macrophages: Innate Memory as an Endogenous Mechanism of IL-1 Inhibition

(2017) Mariusz P. Madej et al.   Frontiers in Pharmacology

Vascular transcriptome profiling identifies Sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction

(2017) Mateusz Siedlinski et al.   Scientific Reports

S1P1 deletion differentially affects TH17 and Regulatory T cells

(2017) Ahmet Eken et al.   Scientific Reports

Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931

(2016) Mieke Veltman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sphingolipids Contribute to Human Atherosclerotic Plaque InflammationHighlights

(2016) Andreas Edsfeldt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Non-allergic asthma as a CFTR-related disorder

(2016) Angela Schulz et al.   Journal of Cystic Fibrosis

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress

(2016) Jesus Zamora-Pineda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

(2016) L. A. Borthwick   Seminars in Immunopathology

Pilot evaluation of ivacaftor for chronic bronchitis

(2016) George M Solomon et al.   Lancet Respiratory Medicine

Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors

(2016) Rachael Wiltshire et al.   Scientific Reports

Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR

(2015) Xiaohua Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sphingosine-1-Phosphate Signaling Regulates Myogenic Responsiveness in Human Resistance Arteries

(2015) Sonya Hui et al.   PLoS One

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

(2015) Firhan A. Malik et al.   PLoS One

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction

(2015) Christoph Tabeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage

(2015) Kenji Yagi et al.   STROKE

The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension

(2014) Jiwang Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate

(2014) Andreas V. Thuy et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels

(2014) Fatemat Hassan et al.   RESPIRATORY RESEARCH

Loss of Cystic Fibrosis Transmembrane Conductance Regulator Impairs Lung Endothelial Cell Barrier Function and Increases Susceptibility to Microvascular Damage from Cigarette Smoke

(2014) Mary Beth Brown et al.   Pulmonary Circulation

Cigarette smoke and CFTR: implications in the pathogenesis of COPD

(2013) Andras Rab et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function

(2013) S. Vamsee Raju et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Post-Transcriptional Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Expression and Function by MicroRNAs

(2013) Shyam Ramachandran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in the Lower Airways in COPD

(2013) Mark T. Dransfield et al.   CHEST

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

(2013) Tsukasa Okiyoneda et al.   Nature Chemical Biology

Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL-Receptor Deficient Mice

(2013) Martine Bot et al.   PLoS One

Low Sphingosine-1–Phosphate Impairs Lung Dendritic Cells in Cystic Fibrosis

(2012) Yaqin Xu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tumor Necrosis Factor-α–Mediated Downregulation of the Cystic Fibrosis Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Signaling in a Mouse Model of Heart Failure

(2012) Anja Meissner et al.   CIRCULATION

Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure via Tumor Necrosis Factor-α–Dependent Activation of Sphingosine-1-Phosphate Signaling

(2012) Jingli Yang et al.   CIRCULATION

Absence of the cystic fibrosis transmembrane regulator (Cftr ) from myeloid-derived cells slows resolution of inflammation and infection

(2012) T. L. Bonfield et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression

(2012) Irina Gorshkova et al.   JOURNAL OF LIPID RESEARCH

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease

(2011) Fabian Cordts et al.   LIFE SCIENCES

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

(2011) Evgeny V. Berdyshev et al.   PLoS One

CFTR: folding, misfolding and correcting the ΔF508 conformational defect

(2011) Gergely L. Lukacs et al.   TRENDS IN MOLECULAR MEDICINE

Sphingosine-1-Phosphate–Dependent Activation of p38 MAPK Maintains Elevated Peripheral Resistance in Heart Failure Through Increased Myogenic Vasoconstriction

(2010) Judith Hoefer et al.   CIRCULATION RESEARCH

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Design and validation of Segment - freely available software for cardiovascular image analysis

(2010) Einar Heiberg et al.   BMC MEDICAL IMAGING

The Phosphorylation Motif at Serine 225 Governs the Localization and Function of Sphingosine Kinase 1 in Resistance Arteries

(2009) Darcy Lidington et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection

(2009) K. Sattler et al.   CARDIOVASCULAR RESEARCH

Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling

(2009) Hiroko Hamai et al.   JOURNAL OF LIPID RESEARCH

Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

(2008) Krishnan Venkataraman et al.   CIRCULATION RESEARCH