T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis

Anti-inflammatory Properties of Simvastatin Mediate Improvement of Memory Function in Aged ApoE-/- Mice

(2018) Nicholas Don-Doncow et al.   ATHEROSCLEROSIS SUPPLEMENTS

Peripheral immune cells infiltrate into sites of secondary neurodegeneration after ischemic stroke

(2018) K.A. Jones et al.   BRAIN BEHAVIOR AND IMMUNITY

The emerging alliance of sphingosine-1-phosphate signalling and immune cells: from basic mechanisms to implications in hypertension

(2018) Nicholas Don-Doncow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Change of Peripheral Blood Treg/Thl7 in Cognitive Impairment with Chronic Renal Failure Patients

(2018) Jie Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

(2018) Giuseppe Faraco et al.   NATURE NEUROSCIENCE

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

The Clinical Significance and Potential Role of C-Reactive Protein in Chronic Inflammatory and Neurodegenerative Diseases

(2018) Ying-yi Luan et al.   Frontiers in Immunology

Neuroinflammation: Microglia and T Cells Get Ready to Tango

(2018) Sjoerd T. T. Schetters et al.   Frontiers in Immunology

Imbalance of Circulating Th17 and Regulatory T Cells in Alzheimer’s Disease: A Case Control Study

(2018) Timo Jan Oberstein et al.   Frontiers in Immunology

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

(2018) Dina Vojinovic et al.   Nature Communications

Systemic Inflammation Mediates Age-Related Cognitive Deficits

(2018) Tian Lin et al.   Frontiers in Aging Neuroscience

S1PR (Sphingosine-1-Phosphate Receptor) Signaling in the Regulation of Vascular Tone and Blood Pressure

(2017) Anja Meissner   HYPERTENSION

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

(2017) Annika Sommer et al.   Molecular Neurodegeneration

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

(2017) Sarah E. Lutz et al.   Cell Reports

Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation

(2017) Serena Quarta et al.   Frontiers in Molecular Neuroscience

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

(2016) Cyril Laurent et al.   BRAIN

Hypertension and the Brain: A Risk Factor for More Than Heart Disease

(2016) Anja Meissner   CEREBROVASCULAR DISEASES

Activation of Human T Cells in HypertensionNovelty and Significance

(2016) Hana A. Itani et al.   HYPERTENSION

Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion

(2016) Manhua Lv et al.   INFLAMMATION RESEARCH

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

(2016) Giuseppe Faraco et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension

(2016) Anja Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment

(2016) L. Riganti et al.   JOURNAL OF NEUROSCIENCE

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In VivoNovelty and Significance

(2015) Nicole Urtz et al.   CIRCULATION RESEARCH

Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia

(2015) Shuli Zheng et al.   EXPERIMENTAL NEUROLOGY

Characteristics of the peripheral T cell immune response of patients at different stages of vascular cognitive impairment

(2015) Peng Guoping et al.   IMMUNOLOGY LETTERS

Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling

(2015) Eunjung Moon et al.   MEDIATORS OF INFLAMMATION

Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel

(2015) Parker C. Wilson et al.   MOLECULAR ENDOCRINOLOGY

Tumor Necrosis Factor-  Underlies Loss of Cortical Dendritic Spine Density in a Mouse Model of Congestive Heart Failure

(2015) A. Meissner et al.   Journal of the American Heart Association

Inflammation and Hypertension: New Understandings and Potential Therapeutic Targets

(2014) Carmen De Miguel et al.   CURRENT HYPERTENSION REPORTS

Sphingosine-1-phosphate lyase is expressed by CD68+cells on the parenchymal side of marginal reticular cells in human lymph nodes

(2014) Saem Mul Park et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation

(2014) Guiying Deng et al.   JOURNAL OF NEUROIMMUNOLOGY

Differential Phenotypes of Tissue-Infiltrating T Cells during Angiotensin II-Induced Hypertension in Mice

(2014) Zihui Wei et al.   PLoS One

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Tumor Necrosis Factor-α–Mediated Downregulation of the Cystic Fibrosis Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Signaling in a Mouse Model of Heart Failure

(2012) Anja Meissner et al.   CIRCULATION

Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure via Tumor Necrosis Factor-α–Dependent Activation of Sphingosine-1-Phosphate Signaling

(2012) Jingli Yang et al.   CIRCULATION

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice

(2011) Gema Tarrasón et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lipid phosphate phosphatase 3 enables efficient thymic egress

(2011) Béatrice Bréart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Association between Hypertension and Dementia in the Elderly

(2011) Michiya Igase et al.   International Journal of Hypertension

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics

(2010) Shobha Thangada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The direct excitatory effect of IL-1β on cerebellar Purkinje cell

(2008) Kazumi Motoki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION

The brain expression of genes involved in inflammatory response, the ribosome and learning and memory is altered by centrally injected lipopolysaccharide in mice

(2008) R H Bonow et al.   PHARMACOGENOMICS JOURNAL

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA