The p38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer

The EGFR‐P38 MAPK axis up‐regulates PD‐L1 through miR‐675‐5p and down‐regulates HLA‐ABC via hexokinase‐2 in hepatocellular carcinoma cells

(2021) Zongcai Liu et al.   Cancer Communications

PD-L1 as a biomarker of response to immune-checkpoint inhibitors

(2021) Deborah Blythe Doroshow et al.   Nature Reviews Clinical Oncology

Diversity and versatility of p38 kinase signalling in health and disease

(2021) Begoña Canovas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SWATH-MS proteomics of PANC-1 and MIA PaCa-2 pancreatic cancer cells allows identification of drug targets alternative to MEK and PI3K inhibition

(2021) Alain Aguilar-Valdés et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1 /2 and p38 MAPK pathway through miR ‐409‐3p/ CDK8 axis

(2021) Bing Zhou et al.   DRUG DEVELOPMENT RESEARCH

Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinoma cell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway

(2021) Jia Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression

(2021) Elmira Roshani Asl et al.   LIFE SCIENCES

p38β - MAPK11 and its role in female cancers

(2021) Periklis Katopodis et al.   Journal of Ovarian Research

Loss of DUSP4 Expression as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma

(2021) Seongsik Bang et al.   Diagnostics

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

(2020) Shannon Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blockade of p38 kinase impedes the mobilization of protumorigenic myeloid populations to impact breast cancer metastasis

(2020) Justin Zonneville et al.   INTERNATIONAL JOURNAL OF CANCER

The p38 Pathway: From Biology to Cancer Therapy

(2020) Adrián Martínez-Limón et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

(2020) Devikala Gurusamy et al.   CANCER CELL

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

(2020) Ara Koh et al.   Cell Metabolism

Prexasertib: an investigational checkpoint kinase inhibitor for the treatment of high-grade serous ovarian cancer

(2020) Giulio Evangelisti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

lncRNA DGCR 5/miR‑27a‑3p/BNIP3 promotes cell apoptosis in pancreatic cancer by regulating the p38 MAPK pathway

(2020) Xianjie Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer

(2020) Ginette S. Santiago-Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p38δ genetic ablation protects female mice from anthracycline cardiotoxicity

(2020) Sharon A. George et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation

(2020) Craig Donoghue et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation

(2020) Galia Maik-Rachline et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p38β and Cancer: The Beginning of the Road

(2020) Olga Roche et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR‑106a‑5p‑mediated P38 MAPK signaling

(2020) Ting Tang et al.   Molecular Medicine Reports

Cancer-induced muscle wasting requires p38beta MAPK activation of p300

(2020) Thomas K Sin et al.   CANCER RESEARCH

Phase 1 trial of ralimetinib (LY2228820) with radiotherapy plus concomitant temozolomide in the treatment of newly diagnosed glioblastoma

(2020) J. Biau et al.   RADIOTHERAPY AND ONCOLOGY

p38β (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models

(2020) R. Pascual-Serra et al.   RADIOTHERAPY AND ONCOLOGY

Prediction Biomarkers Associated with Lymph Node Metastasis and Prognosis were Identified in Papillary Thyroid Carcinoma via Integrated Bioinformatics Analysis

(2020) Siyuan Gan et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression

(2019) Sourabh Soni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

p38γ is essential for cell cycle progression and liver tumorigenesis

(2019) Antonia Tomás-Loba et al.   NATURE

Targeting p38γ to inhibit human colorectal cancer cell progression

(2019) Chang Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prexasertib, a checkpoint kinase inhibitor: from preclinical data to clinical development

(2019) Gesuino Angius et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules

(2019) Álvaro Casadomé-Perales et al.   Nanomedicine

A randomized, double-blind, placebo-controlled phase 1b/2 study of ralimetinib, a p38 MAPK inhibitor, plus gemcitabine and carboplatin versus gemcitabine and carboplatin for women with recurrent platinum-sensitive ovarian cancer

(2019) Ignace Vergote et al.   GYNECOLOGIC ONCOLOGY

Prexasertib increases the sensitivity of pancreatic cancer cells to gemcitabine and S‑1

(2019) Yoshihito Morimoto et al.   ONCOLOGY REPORTS

MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer

(2019) Lorenzo Stramucci et al.   Cell Death & Disease

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

(2019) Braicu et al.   Cancers

Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11

(2019) Zhicheng Yao et al.   Cell Death & Disease

Plakophilin3 loss leads to an increase in lipocalin2 expression, which is required for tumour formation

(2018) Srikanta Basu et al.   EXPERIMENTAL CELL RESEARCH

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations

(2018) Ioannis Zerdes et al.   ONCOGENE

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

(2018) Galia Maik-Rachline et al.   Science Signaling

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition

(2018) Nuria Matesanz et al.   PLOS BIOLOGY

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

(2018) Galia Maik-Rachline et al.   Science Signaling

p38γ and p38δ Are Involved in T Lymphocyte Development

(2018) Ana Risco et al.   Frontiers in Immunology

Role of p38γ MAPK in regulation of EMT and cancer stem cells

(2018) Mei Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss

(2018) Bhavna Murali et al.   CANCER RESEARCH

p38γ and p38δ: From Spectators to Key Physiological Players

(2017) Ana Cuenda et al.   TRENDS IN BIOCHEMICAL SCIENCES

DUSP4 promotes doxorubicin resistance in gastric cancer through epithelial-mesenchymal transition

(2017) Xing Kang et al.   Oncotarget

DUSP4 is associated with increased resistance against anti-HER2 therapy in breast cancer

(2017) Otília Menyhart et al.   Oncotarget

The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells

(2017) Isabelle Corre et al.   Oncotarget

First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes

(2016) Zeynep Yurtsever et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

(2016) Najoua Lalaoui et al.   CANCER CELL

Gene expression profiling of lung adenocarcinoma in Xuanwei, China

(2016) Huifei Wu et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

(2016) Eric H. Bent et al.   GENES & DEVELOPMENT

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction

(2016) Morisada Hayakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new role for cofilin in retinal neovascularization

(2016) Raj Kumar et al.   JOURNAL OF CELL SCIENCE

The Comparative Toxicogenomics Database: update 2017

(2016) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription

(2016) Liang Zhong et al.   Oncotarget

Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ

(2016) Yasumitsu Kondoh et al.   Scientific Reports

Metformin in Cancer Treatment and Prevention

(2015) Daniel R. Morales et al.   Annual Review of Medicine

p38δ MAPK phenotype

(2015) Carol O’Callaghan et al.   ANTI-CANCER DRUGS

The Stress Kinase p38  as a Target for Cancer Therapy

(2015) A. Igea et al.   CANCER RESEARCH

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

(2015) Felix Dietlein et al.   CELL

p38/p53/miR-200a-3p feedback loop promotes oxidative stress-mediated liver cell death

(2015) Yongtao Xiao et al.   CELL CYCLE

A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor, Ralimetinib (LY2228820 Dimesylate), in Patients with Advanced Cancer

(2015) A. Patnaik et al.   CLINICAL CANCER RESEARCH

Focal-adhesion-independent integrin- v regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion

(2015) E. K. Duperret et al.   JOURNAL OF CELL SCIENCE

miR-155 Regulates Glioma Cells Invasion and Chemosensitivity by p38 Isforms In Vitro

(2015) Qiang Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of p38β as a Therapeutic Target for the Treatment of Sézary Syndrome

(2015) Meghan Bliss-Moreau et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway

(2015) Ayako Tsuchiya et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer

(2015) Dan He et al.   Molecular Cancer

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis

(2015) Rafal Zur et al.   Oncotarget

Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade

(2015) Juan F. Linares et al.   Cell Reports

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

Pro-Oncogenic Role of Alternative p38 Mitogen-Activated Protein Kinases p38  and p38 , Linking Inflammation and Cancer in Colitis-Associated Colon Cancer

(2014) P. del Reino et al.   CANCER RESEARCH

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

(2014) Ramona Rudalska et al.   NATURE MEDICINE

DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine

(2014) Fang Liu et al.   PLoS One

p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis

(2014) E. Alspach et al.   Cancer Discovery

SnapShot: p38 MAPK Signaling

(2013) Natalia Trempolec et al.   CELL

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

(2013) Lorena Pereira et al.   EMBO Molecular Medicine

A Role for Protein Phosphatase 2A in Regulating p38 Mitogen Activated Protein Kinase Activation and Tumor Necrosis Factor-Alpha Expression during Influenza Virus Infection

(2013) Anna Law et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p38β, A Novel Regulatory Target of Pokemon in Hepatic Cells

(2013) Zhe Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Membrane Signaling Induced by High Doses of Ionizing Radiation in the Endothelial Compartment. Relevance in Radiation Toxicity

(2013) Isabelle Corre et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth

(2013) CAROL O’CALLAGHAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

LY2228820 Dimesylate, a Selective Inhibitor of p38 Mitogen-activated Protein Kinase, Reduces Angiogenic Endothelial Cord Formationin Vitroandin Vivo

(2013) Courtney M. Tate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis

(2013) Kantima Leelahavanichkul et al.   Molecular Oncology

Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1

(2013) Gian Felice De Nicola et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide promoter methylation analysis identifies epigenetic silencing ofMAPK13in primary cutaneous melanoma

(2013) Linda Gao et al.   Pigment Cell & Melanoma Research

p38γ overexpression in gliomas and its role in proliferation and apoptosis

(2013) Kui Yang et al.   Scientific Reports

p38β MAP Kinase as a Therapeutic Target for Pancreatic Cancer

(2012) Abhay Kumar Singh et al.   Chemical Biology & Drug Design

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

Nuclear Localization of p38 MAPK in Response to DNA Damage

(2012) C. David Wood et al.   International Journal of Biological Sciences

Annexin-1-mediated Endothelial Cell Migration and Angiogenesis Are Regulated by Vascular Endothelial Growth Factor (VEGF)-induced Inhibition of miR-196a Expression

(2012) Anne-Laure Pin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Randomized, dose-escalation study of the p38α MAPK inhibitor SCIO-469 in patients with myelodysplastic syndrome

(2012) L Sokol et al.   LEUKEMIA

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

p38  Promotes Breast Cancer Cell Motility and Metastasis through Regulation of RhoC GTPase, Cytoskeletal Architecture, and a Novel Leading Edge Behavior

(2011) D. T. Rosenthal et al.   CANCER RESEARCH

Evidence of p38γ and p38δ involvement in cell transformation processes

(2011) M.Isabel Cerezo-Guisado et al.   CARCINOGENESIS

Phosphorylation and Stabilization of Topoisomerase IIα Protein by p38γ Mitogen-activated Protein Kinase Sensitize Breast Cancer Cells to Its Poisons

(2011) Xiaomei Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours

(2011) K. J. Schmitz et al.   JOURNAL OF CLINICAL PATHOLOGY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

(2010) Alexander Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting the p38 MAPK Pathway Inhibits Irinotecan Resistance in Colon Adenocarcinoma

(2010) S. Paillas et al.   CANCER RESEARCH

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

Pro-inflammatory angiogenesis is mediated by p38 MAP kinase

(2010) Gangaraju Rajashekhar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

(2010) H. Christian Reinhardt et al.   MOLECULAR CELL

MK2 regulates the early stages of skin tumor promotion

(2009) Claus Johansen et al.   CARCINOGENESIS

p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion

(2009) Felicia Li-Sher Tan et al.   INTERNATIONAL JOURNAL OF CANCER

Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function

(2008) S. Massarweh et al.   CANCER RESEARCH

An Autocrine VEGF/VEGFR2 and p38 Signaling Loop Confers Resistance to 4-Hydroxytamoxifen in MCF-7 Breast Cancer Cells

(2008) R. Aesoy et al.   MOLECULAR CANCER RESEARCH

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE