Mechanical Cues: Bidirectional Reciprocity in the Extracellular Matrix Drives Mechano-Signalling in Articular Cartilage

The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature

(2021) Cécile Lambert et al.   Frontiers in Medicine

Compressive mechanical stress enhances susceptibility to interleukin-1 by increasing interleukin-1 receptor expression in 3D-cultured ATDC5 cells

(2021) Yuki Takeda et al.   BMC MUSCULOSKELETAL DISORDERS

Perlecan in Pericellular Mechanosensory Cell-Matrix Communication, Extracellular Matrix Stabilisation and Mechanoregulation of Load-Bearing Connective Tissues

(2021) Farshid Guilak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRPV2 is involved in induction of lubricin and suppression of ectopic endochondral ossification in articular joints

(2021) Hideki Nakamoto et al.   Arthritis & Rheumatology

Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis

(2021) Weizhou Jiang et al.   AGEING RESEARCH REVIEWS

Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis

(2021) B. Han et al.   OSTEOARTHRITIS AND CARTILAGE

Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage

(2021) Sheetal R Inamdar et al.   Acta Biomaterialia

The LINC Between Mechanical Forces and Chromatin

(2021) Olga Lityagina et al.   Frontiers in Physiology

Anti-inflammatory effects of tibial axial loading on knee articular cartilage post traumatic injury

(2021) Larry Hazbun et al.   JOURNAL OF BIOMECHANICS

Effects of forces on chromatin

(2021) Kshitij Amar et al.   APL Bioengineering

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis

(2020) Ping Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early Changes in Cartilage Pericellular Matrix Micromechanobiology Portend the Onset of Post-Traumatic Osteoarthritis

(2020) Daphney R. Chery et al.   Acta Biomaterialia

Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis

(2020) Zhenxing Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Perlecan knockdown significantly alters extracellular matrix composition and organization during cartilage development

(2020) Alexander R. Ocken et al.   MOLECULAR & CELLULAR PROTEOMICS

The effect of hydrostatic pressure on proteoglycan production in articular cartilage in vitro: a meta-analysis

(2020) E. Hodder et al.   OSTEOARTHRITIS AND CARTILAGE

Decorin Mediates Cartilage Matrix Degeneration and Fibrillation in Post‐Traumatic Osteoarthritis

(2020) Qing Li et al.   Arthritis & Rheumatology

Effects of in vivo cyclic compressive loading on the distribution of local Col2 and superficial lubricin in rat knee cartilage

(2020) Xiang Ji et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lubricin Contributes to Homeostasis of Articular Cartilage by Modulating Differentiation of Superficial Zone Cells

(2020) Yuji Maenohara et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Decorin regulates cartilage pericellular matrix micromechanobiology

(2020) Daphney R. Chery et al.   MATRIX BIOLOGY

Collagen reorganization in cartilage under strain probed by polarization sensitive second harmonic generation microscopy

(2019) Jessica C. Mansfield et al.   Journal of the Royal Society Interface

Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage

(2019) M. Danalache et al.   OSTEOARTHRITIS AND CARTILAGE

TGFβ/BMP Signaling Pathway in Cartilage Homeostasis

(2019) Nathalie G.M. Thielen et al.   Cells

Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix

(2019) Biao Han et al.   ACS Nano

Combined enzymatic degradation of proteoglycans and collagen significantly alters intratissue strains in articular cartilage during cyclic compression

(2019) Maria-Ioana Pastrama et al.   Journal of the Mechanical Behavior of Biomedical Materials

Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes

(2019) Genlai Du et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Assessment of biomechanical properties of the extracellular and pericellular matrix and their interconnection throughout the course of osteoarthritis

(2019) Marina Danalache et al.   JOURNAL OF BIOMECHANICS

Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

(2018) Xiaodi Tang et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis

(2018) Sophie Jane Gilbert et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Osteoarthritis as a disease of the cartilage pericellular matrix

(2018) Farshid Guilak et al.   MATRIX BIOLOGY

Cartilage diseases

(2018) Yamini Krishnan et al.   MATRIX BIOLOGY

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression

(2018) Aimy Sebastian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Local Tensile Stress in the Development of Posttraumatic Osteoarthritis

(2018) Dongyan Zhong et al.   Biomed Research International

Extracellular Distribution of Collagen II and Perifibrillar Adapter Proteins in Healthy and Osteoarthritic Human Knee Joint Cartilage

(2017) Sara Firner et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Functional properties of chondrocytes and articular cartilage using optical imaging to scanning probe microscopy

(2017) Yang Xia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Influence of the pericellular and extracellular matrix structural properties on chondrocyte mechanics

(2017) Mehdi Khoshgoftar et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint

(2017) John H. Rosenberg et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The minor collagens in articular cartilage

(2017) Yunyun Luo et al.   Protein & Cell

Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface

(2017) Sarah A. Flowers et al.   Scientific Reports

Laminins and Nidogens in the Pericellular Matrix of Chondrocytes

(2016) Boris Schminke et al.   AMERICAN JOURNAL OF PATHOLOGY

Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin

(2016) Tobias Gronau et al.   ANNALS OF THE RHEUMATIC DISEASES

Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage

(2016) Xin Xu et al.   DEVELOPMENTAL BIOLOGY

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

YAP and ERK mediated mechanical strain-induced cell cycle progression through RhoA and cytoskeletal dynamics in rat growth plate chondrocytes

(2016) Kaixiang Yang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX −/− mice

(2016) Matthias Kamper et al.   MATRIX BIOLOGY

Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses

(2016) S.L. Dunn et al.   OSTEOARTHRITIS AND CARTILAGE

Unloading results in rapid loss of TGFβ signaling in articular cartilage: role of loading-induced TGFβ signaling in maintenance of articular chondrocyte phenotype?

(2016) W. Madej et al.   OSTEOARTHRITIS AND CARTILAGE

Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice

(2016) Yupeng Chen et al.   PLoS One

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2

(2015) Sophie Lees et al.   Arthritis & Rheumatology

Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage

(2015) Nicole A. Zelenski et al.   Arthritis & Rheumatology

Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments

(2015) Scott T. Wood et al.   Arthritis & Rheumatology

Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review

(2015) Judith Bleuel et al.   PLoS One

TGFβ signaling in cartilage development and maintenance

(2014) Weiguang Wang et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways

(2014) H. Ogawa et al.   GENES & DEVELOPMENT

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue

(2014) J. Swift et al.   JOURNAL OF CELL SCIENCE

A single blunt impact on cartilage promotes fibronectin fragmentation and upregulates cartilage degrading stromelysin-1/matrix metalloproteinase-3 in a bovineex vivomodel

(2014) Lei Ding et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The structure and function of the pericellular matrix of articular cartilage

(2014) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling

(2014) W. Madej et al.   OSTEOARTHRITIS AND CARTILAGE

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

(2014) Bridgette D Furman et al.   ARTHRITIS RESEARCH & THERAPY

The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis

(2014) Johannah Sanchez-Adams et al.   Current Rheumatology Reports

Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues

(2014) Casper Bindzus Foldager et al.   Cartilage

Deletion of P58IPK, the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice

(2014) Sophie J. Gilbert et al.   Frontiers in Endocrinology

Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers

(2013) Josef A. Stolberg-Stolberg et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage

(2013) R.E. Wilusz et al.   OSTEOARTHRITIS AND CARTILAGE

Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold

(2013) Y. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Fibroblast growth factor control of cartilage homeostasis

(2012) M.B. Ellman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanically induced calcium signaling in chondrocytes in situ

(2012) Sang-Kuy Han et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Changes in chondrocyte gene expression following in vitro impaction of porcine articular cartilage in an impact injury model

(2012) Melissa S. Ashwell et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A biomechanical role for perlecan in the pericellular matrix of articular cartilage

(2012) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Dynamic Compression of Chondrocyte-Agarose Constructs Reveals New Candidate Mechanosensitive Genes

(2012) Carole Bougault et al.   PLoS One

Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage

(2011) Kotaro Tanimoto et al.   CELL AND TISSUE RESEARCH

Moderate Joint Loading Reduces Degenerative Actions of Matrix Metalloproteinases in the Articular Cartilage of Mouse Ulnae

(2011) Hui B. Sun et al.   CONNECTIVE TISSUE RESEARCH

A proteomic approach for identification and localization of the pericellular components of chondrocytes

(2011) Zijun Zhang et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Type IX Collagen Interacts with Fibronectin Providing an Important Molecular Bridge in Articular Cartilage

(2011) Philippa Parsons et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Finite element prediction of cartilage contact stresses in normal human hips

(2011) Michael D. Harris et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan

(2011) A. D. Berendsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tenascin-C fragments are endogenous inducers of cartilage matrix degradation

(2011) Nidhi Sofat et al.   RHEUMATOLOGY INTERNATIONAL

Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis

(2011) Rhian S Thomas et al.   ARTHRITIS RESEARCH & THERAPY

Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4

(2010) Jeffrey M. Coles et al.   ARTHRITIS AND RHEUMATISM

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

The matrilins: Modulators of extracellular matrix assembly

(2010) Andreas R. Klatt et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Type III Collagen, a Fibril Network Modifier in Articular Cartilage

(2010) Jiann-Jiu Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF 

(2010) T. Massam-Wu et al.   JOURNAL OF CELL SCIENCE

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury

(2009) Aled R. C. Jones et al.   ARTHRITIS AND RHEUMATISM

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor α in immature bovine and adult human articular cartilage

(2009) Yihong Sui et al.   ARTHRITIS AND RHEUMATISM

Developmental and osteoarthritic changes inCol6a1-knockout mice: Biomechanics of type VI collagen in the cartilage pericellular matrix

(2009) Leonidas G. Alexopoulos et al.   ARTHRITIS AND RHEUMATISM

Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: Cartilage oligomeric matrix protein counteracts type IX collagen–induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures

(2009) K. Blumbach et al.   ARTHRITIS AND RHEUMATISM

In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes

(2009) Wei-Hong Chen et al.   ARTHRITIS AND RHEUMATISM

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

(2009) Ren Xu et al.   CANCER AND METASTASIS REVIEWS

Fell-Muir Lecture: Proteoglycans and more - from molecules to biology

(2009) Dick Heinegård   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Deficiency of tenascin-C delays articular cartilage repair in mice

(2009) N. Okamura et al.   OSTEOARTHRITIS AND CARTILAGE

Nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage

(2008) Jenny Kruegel et al.   ARTHRITIS AND RHEUMATISM

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs

(2008) J.T. Connelly et al.   OSTEOARTHRITIS AND CARTILAGE

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

(2008) James Melrose et al.   ARTHRITIS RESEARCH & THERAPY

The major basement membrane components localize to the chondrocyte pericellular matrix — A cartilage basement membrane equivalent?

(2007) Alexander J. Kvist et al.   MATRIX BIOLOGY