Review
Biochemistry & Molecular Biology
Jiarui Cui, Jiaming Zhang
Summary: Cartilage oligomeric matrix protein (COMP) plays a critical role in collagen assembly and ECM stability in the extracellular matrix. Mutations in COMP can lead to endoplasmic reticulum stress and chondrocyte apoptosis, resulting in rare skeleton diseases. COMP acts as a bridging molecule with its bouquet-like structure, regulating cellular phenotype and function by interacting with ECM components, cellular receptors, and growth factors. Recent studies suggest that COMP may also be involved in other skeleton diseases, malignancy, cardiovascular diseases, and tissue fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xiang Li, Shiao Li, Jiatian Qian, Yancheng Chen, Yiqin Zhou, Peiliang Fu
Summary: The study demonstrated that type I collagen-based MACT is an effective treatment for improving functionality and pain levels. Histological evidence confirmed hyaline cartilage induction and showed that repaired cartilage tended to emerge from the deep to the superficial layer. The quantitative MRI T2 mapping test indicated that there still was a difference between the transplanted cartilage and the surrounding hyaline cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Immunology
Anna M. Blom, Chrysostomi Gialeli, Catharina Hagerling, Jonna Berntsson, Karin Jirstrom, Konstantinos S. Papadakos
Summary: This study found that the expression level of COMP is associated with clinopathological features of colorectal cancer (CRC), such as TNM stage and grade of differentiation. CRC patients with high COMP expression have shorter overall survival and fewer infiltrating T-cells. There is a negative correlation between COMP expression and PD-L1 expression. These findings highlight the importance of COMP in the development and progression of CRC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Awuniji Linus, Mohammadhossein Ebrahimi, Mikael J. Turunen, Simo Saarakkala, Antti Joukainen, Heikki Kroger, Arto Koistinen, Mikko A. J. Finnila, Isaac O. Afara, Mika E. Mononen, Petri Tanska, Rami K. Korhonen
Summary: High-resolution Fourier transform infrared microspectroscopy (HR-FTIR-MS) was used to characterize collagen content in the chondrocyte microenvironment, revealing collagen loss in the pericellular region in early osteoarthritis before extending to the extracellular matrix in advanced stages. This technique may facilitate the discovery of new mechanisms and improve treatment strategies for osteoarthritis.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Jacqueline T. Hecht, Alka C. Veerisetty, Mohammad G. Hossain, Frankie Chiu, Karen L. Posey
Summary: Mutations in COMP lead to protein misfolding and accumulation in chondrocytes, causing skeletal growth abnormalities and joint health issues. Autophagy blockage and elevated mTORC1 signaling play a key role in the intracellular accumulation of mutant-COMP. Resveratrol and CurQ+ have shown potential in alleviating autophagy blockage, reducing inflammation, and restoring chondrocyte proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yu-Hsuan Kuo, Hong-Yue Lai, Ti-Chun Chan, Chung-Hsi Hsing, Steven K. Huang, Kun-Lin Hsieh, Tzu-Ju Chen, Wan-Shan Li, Jhih-Cheng Lu, Chien-Feng Li
Summary: The overexpression of cartilage oligomeric matrix protein (COMP) in urothelial carcinoma is associated with tumor progression, metastasis, and patient survival rates. COMP may serve as a potential biomarker for urothelial carcinoma.
ONCOTARGETS AND THERAPY
(2022)
Article
Orthopedics
Akinola Akinmade, Lawrence M. Oginni, Olayinka O. Adegbehingbe, Abiodun I. Okunlola, Olusola A. Jeje, Adeolu I. Adeyeye
Summary: The study found that serum COMP levels were significantly higher in patients with knee OA than in those without the disease. Values of sCOMP were also found to increase with severity of knee OA, indicating the possibility of its use as a marker of diagnosis and severity.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Cell Biology
Jin Cheng, Xiaoning Duan, Xin Fu, Yanfang Jiang, Peng Yang, Chenxi Cao, Qi Li, Jiying Zhang, Xiaoqing Hu, Xin Zhang, Yingfang Ao
Summary: The study shows that RIP1 plays a crucial role in the onset and progression of osteoarthritis (OA) by mediating chondrocyte necroptosis and disrupting extracellular matrix (ECM) metabolism. Inhibition of RIP1 activity protects rats from cartilage degradation and limb pain, and bone morphogenetic protein 7 (BMP7) is identified as a downstream target that mediates RIP1-induced chondrocyte necroptosis and OA manifestations. This provides a new therapeutic target for OA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jacqueline T. Hecht, Alka C. Veerisetty, Mohammad G. Hossain, Debabrata Patra, Frankie Chiu, Francoise Coustry, Karen L. Posey
Summary: Research on PSACH revealed that mutant-COMP in articular chondrocytes leads to ER stress and blockage of autophagy, resulting in joint degeneration and inflammation. Interventions targeting cellular stress and preserving joint health could offer new therapeutic strategies for PSACH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Maria A. Cruz, Yamilet Gonzalez, Javier A. Velez A. Toro, Makan Karimzadeh, Anthony Rubbo, Lauren Morris, Ramapaada Medam, Taylor Splawn, Marilyn Archer, Russell J. Fernandes, James E. Dennis, Thomas J. Kean
Summary: This study successfully established a high-throughput platform for identifying optimal physiological culture parameters for chondrogenesis by using a Design of Experiments approach and secreted reporter cells in 3D aggregate culture.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Panneerselvam Jithendra, Jamal Moideen Muthu Mohamed, Dinesh Annamalai, Rasha Hamed Al-Serwi, Ateya Megahed Ibrahim, Mohamed El-Sherbiny, Abraham Merlin Rajam, Mamdouh Eldesoqui, Nimer Mansour
Summary: The chondrogenic efficacy of aloe vera blended collagen-chitosan (COL-CS-AV) porous scaffold was investigated using articular chondrocytes. The scaffold showed higher chondrogenic efficacy compared to COL-CS, making it a suitable candidate for cartilage tissue engineering. The study utilized various assays and staining techniques to analyze cytocompatibility, GAG content, RNA content, and expression of cartilage-specific genes and collagen type II.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jacqueline T. Hecht, Alka C. Veerisetty, Debabrata Patra, Mohammad G. Hossain, Frankie Chiu, Claire Mobed, Francis H. Gannon, Karen L. Posey
Summary: The mechanisms underlying the mutant-COMP pathology have been defined using the MT-COMP mouse model. Resveratrol treatment can protect joint health and reduce pain by stimulating autophagy and reducing inflammation, but it needs to start within 4 weeks to be effective.
Review
Biochemistry & Molecular Biology
Darina Bacenkova, Marianna Trebunova, Jana Demeterova, Jozef Zivcak
Summary: Hyaline cartilage lacks self-repair potential, but tissue engineering methods can be used to address the issue of cartilage defect repair. Research shows that chondrocytes and mesenchymal stromal cells have favorable repair abilities in a three-dimensional culture environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xiangying Ma, Zhiheng Zhang, Meilun Shen, Yuanqiang Ma, Rouqian Li, Xiaodi Jin, Li Gao, Zhi Wang
Summary: Osteoarthritis is characterized by progressive degeneration of cartilage and remodeling of subchondral bone, induced by pro-inflammatory cytokines like IL-1 beta. Biomarkers for diagnosing OA effectively are currently not available. Studying the mechanism of cartilage injury and changes in biomarker concentrations during pathogenesis can provide a theoretical basis for evaluation and early diagnosis of OA.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yoshifumi Kimira, Takahiro Sato, Mayu Sakamoto, Yoshihiro Osawa, Hiroshi Mano
Summary: This study investigates the effects of Pro-Hyp on the differentiation of ATDC5 chondrogenic cells under hypoxic conditions. The results show that Pro-Hyp significantly promotes the early differentiation of chondrocytes under physiological hypoxic conditions, suggesting its potential role as a remodeling factor or extracellular matrix remodeling signal that regulates chondrocyte differentiation in hypoxic cartilage.
Article
Orthopedics
Sohrab Khatab, Gerben M. van Buul, Nicole Kops, Yvonne M. Bastiaansen-Jenniskens, P. Koen Bos, Jan A. Verhaar, Gerjo J. van Osch
AMERICAN JOURNAL OF SPORTS MEDICINE
(2018)
Article
Dermatology
Tobias C. Messemaker, Loubna Chadli, Guoshuai Cai, Varshna S. Goelela, Maaike Boonstra, Annemarie L. Dorjee, Stefan N. Andersen, Harald M. M. Mikkers, Peter Van't Hof, Hailiang Mei, Oliver Distler, Harmen H. M. Draisma, Michael E. Johnson, Nicole M. Orzechowski, Robert W. Simms, Rene E. M. Toes, Jamil Aarbiou, Tom W. Huizinga, Michael L. Whitfield, Jeroen DeGroot, Jeska de Vries-Bouwstra, Fina Kurreeman
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Orthopedics
U. T. Timur, M. M. J. Caron, Y. M. Bastiaansen-Jenniskens, T. J. M. Welting, L. W. van Rhijn, G. J. V. M. van Osch, P. J. Emans
OSTEOARTHRITIS AND CARTILAGE
(2018)
Article
Cell & Tissue Engineering
Panithi Sukho, Jan Willem Hesselink, Nicole Kops, Jolle Kirpensteijn, Femke Verseijden, Yvonne M. Bastiaansen-Jenniskens
STEM CELLS AND DEVELOPMENT
(2018)
Review
Cell & Tissue Engineering
Panithi Sukho, Abigael Cohen, Jan Willem Hesselink, Jolle Kirpensteijn, Femke Verseijden, Yvonne M. Bastiaansen-Jenniskens
TISSUE ENGINEERING PART B-REVIEWS
(2018)
Article
Orthopedics
Lizette Utomo, Susanne M. Eijgenraam, Duncan E. Meuffels, Sita M. A. Bierma-Zeinstra, Yvonne M. Bastiaansen-Jenniskens, Gerjo J. V. M. van Osch
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Orthopedics
Arne van de Vyver, Stefan Clockaerts, Chris H. A. van de Lest, Wu Wei, Jan Verhaar, Gerjo J. V. M. Van Osch, Yvonne M. Bastiaansen-Jenniskens
Article
Multidisciplinary Sciences
Panithi Sukho, Geesien S. A. Boersema, Nicole Kops, Johan F. Lange, Jolle Kirpensteijn, Jan Willem Hesselink, Yvonne M. Bastiaansen-Jenniskens, Femke Verseijden
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Susanne M. Eijgenraam, Frans A. T. Bovendeert, Joost Verschueren, Jasper van Tiel, Yvonne M. Bastiaansen-Jenniskens, Marinus A. Wesdorp, Kazem Nasserinejad, Duncan E. Meuffels, Jamal Guenoun, Stefan Klein, Max Reijman, Edwin H. G. Oei
EUROPEAN RADIOLOGY
(2019)
Article
Engineering, Biomedical
F. Razzi, L. E. Fratila-Apachitei, N. Fahy, Y. M. Bastiaansen-Jenniskens, I Apachitei, E. Farrell, A. A. Zadpoor
BIOMEDICAL MATERIALS
(2020)
Article
Orthopedics
Marinus A. Wesdorp, Susanne M. Eijgenraam, Duncan E. Meuffels, Sita M. A. Bierma-Zeinstra, Gert-Jan Kleinrensink, Yvonne M. Bastiaansen-Jenniskens, Max Reijman
AMERICAN JOURNAL OF SPORTS MEDICINE
(2020)
Article
Multidisciplinary Sciences
Loubna Chadli, Britt Sotthewes, Kejie Li, Stefan N. Andersen, Ellen Cahir-McFarland, Marc Cheung, Patrick Cullen, Annemarie Dorjee, Jeska K. de Vries-Bouwstra, Tom W. J. Huizinga, David F. Fischer, Jeroen DeGroot, Joanne L. Viney, Timothy S. Zheng, Jamil Aarbiou, Agnes Gardet
SCIENTIFIC REPORTS
(2019)
Article
Cell & Tissue Engineering
S. Khatab, G. J. V. M. van Osch, N. Kops, Y. M. Bastiaansen-Jenniskens, P. K. Bos, J. A. N. Verhaar, M. R. Bernsen, G. M. van Buul
EUROPEAN CELLS & MATERIALS
(2018)
Article
Rheumatology
Anja J. de Jong, Inge R. Klein-Wieringa, Stefan N. Andersen, Joanneke C. Kwekkeboom, Linda Herb-van Toorn, Badelog J. E. de lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, J. L. van der Heide, Yvonne M. Bastiaansen-Jenniskens, Gerjo J. V. M. van Osch, Annemarie M. Zuurmond, Vedrana Stojanovic-Susulic, Rob G. H. H. Nelissen, Rene E. M. Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay
ARTHRITIS RESEARCH & THERAPY
(2017)
Article
Engineering, Biomedical
Panithi Sukho, Geesien S. A. Boersema, Abigael Cohen, Nicole Kops, Johan F. Lange, Jolle Kirpensteijn, Jan Willem Hesselink, Yvonne M. Bastiaansen-Jenniskens, Femke Verseijden