Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsońs disease through the modulation of neuroinflammation, neurogenesis and neuroplasticity

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

(2021) Maheedhar Kodali et al.   AGING CELL

Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice

(2021) Wilma Helena Oliveira et al.   EXPERIMENTAL BRAIN RESEARCH

Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice

(2020) Junqiang Yan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroprotection of GLP-1/GIP receptor agonist via inhibition of mitochondrial stress by AKT/JNK pathway in a Parkinson's disease model

(2020) Tian Li et al.   LIFE SCIENCES

Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging

(2020) Young-Kyoung Ryu et al.   NEUROPHARMACOLOGY

Ketamine reversed short-term memory impairment and depressive-like behavior in animal model of Parkinson's disease

(2020) Débora Dalla Vecchia et al.   BRAIN RESEARCH BULLETIN

Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus

(2019) Silvia Poggini et al.   NEURAL PLASTICITY

Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death

(2019) Matthew J Keuss et al.   EMBO JOURNAL

Is There a Role of Autophagy in Depression and Antidepressant Action?

(2019) Nils C. Gassen et al.   Frontiers in Psychiatry

Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation

(2019) Wenting Fang et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson’s disease

(2019) Nada Saewanee et al.   NEUROSCIENCE RESEARCH

Pioglitazone reduces mortality, prevents depressive-like behavior, and impacts hippocampal neurogenesis in the 6-OHDA model of Parkinson's disease in rats

(2018) Jéssica Mendes Bonato et al.   EXPERIMENTAL NEUROLOGY

Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression

(2018) Sara A. Khedr et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Patterns and Predictors of Depression Treatment among Older Adults with Parkinson’s Disease and Depression in Ambulatory Care Settings in the United States

(2018) Sandipan Bhattacharjee et al.   Parkinsons Disease

Depression and adult neurogenesis: positive effects of the antidepressant fluoxetine and of physical exercise

(2018) Laura Micheli et al.   BRAIN RESEARCH BULLETIN

Fluoxetine-mediated inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of Parkinson’s disease

(2018) Tao Peng et al.   Aging-US

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

(2018) Fu-yi Liu et al.   Journal of Neuroinflammation

AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration

(2017) Christina Alves Peixoto et al.   EXPERIMENTAL NEUROLOGY

Effect of Metformin on Adult Hippocampal Neurogenesis: Comparison with Donepezil and Links to Cognition

(2017) Sara Ahmed et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA

(2017) Katarzyna Kuter et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide synthase

(2017) Marco Aurélio Mori et al.   NUTRITIONAL NEUROSCIENCE

Adult neurogenesis and neurodegenerative diseases: A systems biology perspective

(2016) Emrin Horgusluoglu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Research in Parkinson′s disease in India: A review

(2016) PramodKumar Pal et al.   Annals of Indian Academy of Neurology

Reward and Aversion

(2016) Hailan Hu   Annual Review of Neuroscience

Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice

(2016) Wilma Helena Oliveira et al.   BRAIN RESEARCH

Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson’s disease

(2016) Rishi Pal et al.   NEUROLOGICAL RESEARCH

Time course study of microglial and behavioral alterations induced by 6-hydroxydopamine in rats

(2016) Thiago Pereira da Silva et al.   NEUROSCIENCE LETTERS

Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson’s disease

(2014) MIA KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neuroendocrine link between stress, depression and diabetes

(2014) Jan Detka et al.   Pharmacological Reports

Inflamed moods: A review of the interactions between inflammation and mood disorders

(2014) Joshua D. Rosenblat et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Fluoxetine inhibits transient global ischemia-induced hippocampal neuronal death and memory impairment by preventing blood–brain barrier disruption

(2013) Jee Y. Lee et al.   NEUROPHARMACOLOGY

Measuring Motor Coordination in Mice

(2013) Robert M.J. Deacon   Jove-Journal of Visualized Experiments

Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?

(2012) Robert K McNamara et al.   Expert Review of Neurotherapeutics

Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse

(2010) Lori M. Gorton et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Doxycycline is Neuroprotective Against Nigral Dopaminergic Degeneration by a Dual Mechanism Involving MMP-3

(2009) Yuri Cho et al.   NEUROTOXICITY RESEARCH

Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   BIOLOGICAL PSYCHIATRY

Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells

(2008) J.-W. Wang et al.   JOURNAL OF NEUROSCIENCE

Anhedonia and activity deficits in rats: impact of post-stroke depression

(2008) SH Wang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The neuropathological basis for depression in Parkinson's disease

(2008) Pasquale G. Frisina et al.   PARKINSONISM & RELATED DISORDERS

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL