The evolution of metazoan shelterin

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization

(2021) Ci Ji Lim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of human telomerase holoenzyme with bound telomeric DNA

(2021) George E. Ghanim et al.   NATURE

Structures of telomerase at several steps of telomere repeat synthesis

(2021) Yao He et al.   NATURE

TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis

(2021) Sherilyn Grill et al.   JCI Insight

Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions

(2020) Marjia Afrin et al.   mSphere

The structure of human CST reveals a decameric assembly bound to telomeric DNA

(2020) Ci Ji Lim et al.   SCIENCE

Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair

(2020) Colleen C. Caldwell et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Telomerase structures and regulation: shedding light on the chromosome end

(2019) Thi Hoang Duong Nguyen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Evolving Linear Chromosomes and Telomeres: A C-Strand-Centric View

(2018) Neal F. Lue   TRENDS IN BIOCHEMICAL SCIENCES

The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action

(2018) Sherilyn Grill et al.   Cell Reports

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b

(2018) Katja Kratz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TimeTree: A Resource for Timelines, Timetrees, and Divergence Times

(2017) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

TRF2 binds branched DNA to safeguard telomere integrity

(2017) Isabelle Schmutz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phylointeractomics reconstructs functional evolution of protein binding

(2017) Dennis Kappei et al.   Nature Communications

Structural and functional analysis of the human POT1-TPP1 telomeric complex

(2017) Cory Rice et al.   Nature Communications

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer

(2017) Cong Chen et al.   Nature Communications

TRF2 binds branched DNA to safeguard telomere integrity

(2017) Isabelle Schmutz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres

(2016) Neil R. Lloyd et al.   BIOCHEMISTRY

TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends

(2016) Akimitsu Konishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stop pulling my strings — what telomeres taught us about the DNA damage response

(2016) Eros Lazzerini-Denchi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A higher-order entity formed by the flexible assembly of RAP1 with TRF2

(2016) Guillaume Gaullier et al.   NUCLEIC ACIDS RESEARCH

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

(2016) Rekha Rai et al.   Nature Communications

Tree of Life Reveals Clock-Like Speciation and Diversification

(2015) S. Blair Hedges et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A loopy view of telomere evolution

(2015) Titia de Lange   Frontiers in Genetics

The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres

(2014) Adélaïde Saint-Léger et al.   CELL CYCLE

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

(2014) Alec N. Sexton et al.   GENES & DEVELOPMENT

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation

(2014) Shaheen Kabir et al.   Cell Reports

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

If the cap fits, wear it: an overview of telomeric structures over evolution

(2013) Nick Fulcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model Space

(2012) Fredrik Ronquist et al.   SYSTEMATIC BIOLOGY

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms

(2011) Yong Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA

(2011) Anaïs Poulet et al.   NUCLEIC ACIDS RESEARCH

Zebrafish as a Model System to Study the Physiological Function of Telomeric Protein TPP1

(2011) Yiying Xie et al.   PLoS One

Shelterin complex and associated factors at human telomeres

(2011) Raffaella Diotti et al.   Nucleus

Taking apart Rap1

(2010) Shaheen Kabir et al.   CELL CYCLE

A Shld1-Controlled POT1a Provides Support for Repression of ATR Signaling at Telomeres through RPA Exclusion

(2010) Yi Gong et al.   MOLECULAR CELL

In Brief

(2010)   NATURE REVIEWS GENETICS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Developmental studies of Xenopus shelterin complexes: the message to reset telomere length is already present in the egg

(2009) Dzeneta Vizlin-Hodzic et al.   FASEB JOURNAL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

The other nanotech

(2009)   Nature Nanotechnology

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

(2009) Hyeung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins

(2008) Y. Chen et al.   SCIENCE