TRF2 binds branched DNA to safeguard telomere integrity

Late Pleistocene archaic human crania from Xuchang, China

(2017) Zhan-Yang Li et al.   SCIENCE

TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends

(2016) Akimitsu Konishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stop pulling my strings — what telomeres taught us about the DNA damage response

(2016) Eros Lazzerini-Denchi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A balance between elongation and trimming regulates telomere stability in stem cells

(2016) Teresa Rivera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

(2016) Rekha Rai et al.   Nature Communications

A balance between elongation and trimming regulates telomere stability in stem cells

(2016) Teresa Rivera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites

(2015) R. Gonzalez-Prieto et al.   EMBO REPORTS

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres

(2014) Adélaïde Saint-Léger et al.   CELL CYCLE

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

The Role of Double-Strand Break Repair Pathways at Functional and Dysfunctional Telomeres

(2014) Y. Doksani et al.   Cold Spring Harbor Perspectives in Biology

The Dissolution of Double Holliday Junctions

(2014) A. H. Bizard et al.   Cold Spring Harbor Perspectives in Biology

Holliday Junction Resolvases

(2014) H. D. M. Wyatt et al.   Cold Spring Harbor Perspectives in Biology

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation

(2014) Shaheen Kabir et al.   Cell Reports

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Normal mammalian cells negatively regulate telomere length by telomere trimming

(2011) H. A. Pickett et al.   HUMAN MOLECULAR GENETICS

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

(2011) Kaori K. Takai et al.   MOLECULAR CELL

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

TRF2 promotes, remodels and protects telomeric Holliday junctions

(2009) Anaïs Poulet et al.   EMBO JOURNAL

Control of telomere length by a trimming mechanism that involves generation of t-circles

(2009) Hilda A Pickett et al.   EMBO JOURNAL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomere Protection by TPP1 Is Mediated by POT1a and POT1b

(2009) T. Kibe et al.   MOLECULAR AND CELLULAR BIOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics