Control of telomerase action at human telomeres

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle

(2015) Jacob M. Vogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

Telomerase Activation after Recruitment in Fission Yeast

(2014) Christine Anne Armstrong et al.   CURRENT BIOLOGY

A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice

(2014) D. Frescas et al.   GENES & DEVELOPMENT

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

(2014) Alec N. Sexton et al.   GENES & DEVELOPMENT

The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7

(2014) Ivo Zemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomeropathies: An emerging spectrum disorder

(2014) Brody Holohan et al.   JOURNAL OF CELL BIOLOGY

Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance

(2014) Yanlian Chen et al.   NUCLEIC ACIDS RESEARCH

The Role of Double-Strand Break Repair Pathways at Functional and Dysfunctional Telomeres

(2014) Y. Doksani et al.   Cold Spring Harbor Perspectives in Biology

The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch

(2014) Neal F. Lue et al.   Nature Communications

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation

(2014) Shaheen Kabir et al.   Cell Reports

Identification of human TERT elements necessary for telomerase recruitment to telomeres

(2014) Jens C Schmidt et al.   eLife

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase

(2013) Ji Hoon Lee et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Inhibition of Telomerase Recruitment and Cancer Cell Death

(2013) Mai Nakashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres

(2013) Emilio Cusanelli et al.   MOLECULAR CELL

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme

(2012) Alec N. Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Enhanced H/ACA RNP Assembly Mechanism for Human Telomerase RNA

(2012) E. D. Egan et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently

(2012) J. L. Stern et al.   MOLECULAR AND CELLULAR BIOLOGY

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Biogenesis of telomerase ribonucleoproteins

(2012) E. D. Egan et al.   RNA

POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics

(2012) Helen Hwang et al.   STRUCTURE

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

(2011) F. Zhong et al.   GENES & DEVELOPMENT

A role for heterochromatin protein 1  at human telomeres

(2011) S. Canudas et al.   GENES & DEVELOPMENT

TIN2 Protein Dyskeratosis Congenita Missense Mutants Are Defective in Association with Telomerase

(2011) Dong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

It all comes together at the ends: Telomerase structure, function, and biogenesis

(2011) Joshua D. Podlevsky et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation

(2011) Jason A. Stewart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection

(2011) Rekha Rai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Architecture of human telomerase RNA

(2011) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of telomeres and telomerase in cancer

(2011) Jerry W. Shay et al.   SEMINARS IN CANCER BIOLOGY

Evolution of CST function in telomere maintenance

(2010) Carolyn Price et al.   CELL CYCLE

A Cajal body-independent pathway for telomerase trafficking in mice

(2010) Rebecca L. Tomlinson et al.   EXPERIMENTAL CELL RESEARCH

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

(2010) E. Abreu et al.   MOLECULAR AND CELLULAR BIOLOGY

Box H/ACA Small Ribonucleoproteins

(2010) Tamás Kiss et al.   MOLECULAR CELL

Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome

(2010) F. Touzot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

(2009) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles

(2009) Kazimierz T. Tycowski et al.   MOLECULAR CELL

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

Chromatin regulation and non-coding RNAs at mammalian telomeres

(2009) Stefan Schoeftner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

(2008) Sharon A. Savage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

(2008) A. J. Walne et al.   BLOOD

Physiological assembly and activity of human telomerase complexes

(2007) Kathleen Collins   MECHANISMS OF AGEING AND DEVELOPMENT