4.7 Article

Co-encapsulation of curcumin and β-carotene in Pickering emulsions stabilized by complex nanoparticles: Effects of microfluidization and thermal treatment

Journal

FOOD HYDROCOLLOIDS
Volume 122, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2021.107064

Keywords

Curcumin; beta-Carotene; Pickering emulsion; Microfluidization; Thermal treatment; In vitro gastrointestinal digestion

Funding

  1. National Natural Science Foundation of China [31871842]
  2. Tsinghua Uni-versity Branch of China National Center Protein Sciences

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The study demonstrated that suitable parameters for stable beta-carotene loaded Pickering emulsions were a particle concentration of 2.0%, an operating pressure of 100 MPa, and a heating temperature of 60 degrees Celsius. Co-encapsulation showed a synergistic effect on improving the photothermal stability of beta-carotene and curcumin, but higher particle concentrations and heating temperatures may decrease bioaccessibility.
The objective of this study was to explore the influence of different particle concentrations (0.5%-3.0 %, w/v), microfluidization pressures (0-150 MPa) and heating temperatures (30-70 degrees C) on the physicochemical stability, microstructure, and in vitro digestion of beta-carotene loaded Pickering emulsions stabilized by curcumin loaded complex nanoparticles. The optimum parameters for the fabrication of stable beta-carotene loaded Pickering emulsions were 2.0 % (w/v) of particle concentration, 100 MPa of operating pressure and 60 degrees C of heating temperature. The co-encapsulation exhibited a synergistic effect on improving the photothermal stability of beta-carotene and curcumin entrapped. During in vitro gastrointestinal digestion, the increased particle concentration (>2.0 %, w/v) and heating temperature (>50 degrees C) retarded the FFA release from the emulsions and reduced the bioaccessibility of curcumin and beta-carotene through droplet flocculation. However, the lower pressure (<100 MPa) promoted lipolysis and enhanced the bioaccessibility of nutraceuticals. The Pickering emulsion was designed for the co-delivery of curcumin and beta-carotene via microfluidization and thermal treatment, which showed the great potential to be applied in the industrial production of functional foods and dietary supplements.

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