Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective

Phytosterol Profiles, Genomes and Enzymes – An Overview

(2021) Sylvain Darnet et al.   Frontiers in Plant Science

Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake

(2021) Miaoqing Hu et al.   Science Advances

Nanomechanics of the Endothelial Glycocalyx

(2020) Zülfü Cem Cosgun et al.   AMERICAN JOURNAL OF PATHOLOGY

Staying in touch with the endocytic network: the importance of contacts for cholesterol transport

(2020) Andrea Martello et al.   TRAFFIC

Structural basis for itraconazole-mediated NPC1 inhibition

(2020) Tao Long et al.   Nature Communications

Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps

(2020) Sanath Kumar et al.   Microorganisms

The lysosome: A potential juncture between SARS‐CoV‐2 infectivity and Niemann‐Pick disease type C, with therapeutic implications

(2020) Rami A. Ballout et al.   FASEB JOURNAL

Metabolomic Studies of Lipid Storage Disorders, with Special Reference to Niemann-Pick Type C Disease: A Critical Review with Future Perspectives

(2020) Benita Claire Percival et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

(2020) Piyali Saha et al.   eLife

Lysosomal Biology and Function: Modern View of Cellular Debris Bin

(2020) Purvi C. Trivedi et al.   Cells

Closing the Gap: Membrane Contact Sites in the Regulation of Autophagy

(2020) Verena Kohler et al.   Cells

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

(2020) Leonhard Möckl   Frontiers in Cell and Developmental Biology

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

(2020) Hongwu Qian et al.   CELL

CHOLESTEROL REVIEW: A METABOLICALLY IMPORTANT MOLECULE

(2020) David S. Schade et al.   Endocrine Practice

Highlights to phytosterols accumulation and equilibrium in plants: Biosynthetic pathway and feedback regulation

(2020) Xuan Zhang et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Cholesterol Handling in Lysosomes and Beyond

(2020) Ying Meng et al.   TRENDS IN CELL BIOLOGY

New Perspectives on SNARE Function in the Yeast Minimal Endomembrane System

(2020) James H. Grissom et al.   Genes

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

(2020) Ching-Shin Huang et al.   Science Advances

An Acquired and Endogenous Glycocalyx Forms a Bidirectional “Don’t Eat” and “Don’t Eat Me” Barrier to Phagocytosis

(2020) Paul R.C. Imbert et al.   CURRENT BIOLOGY

Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway

(2020) Kostadin Petrov et al.   DEVELOPMENTAL CELL

Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases

(2020) Anna Kloska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and Functional Diversity of Resistance–Nodulation–Cell Division Transporters

(2020) Philip A. Klenotic et al.   CHEMICAL REVIEWS

NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

(2019) Suzanne R. Pfeffer   JOURNAL OF BIOLOGICAL CHEMISTRY

The vacuolar shapes of ageing: From function to morphology

(2019) Andreas Aufschnaiter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Physical Principles of Membrane Shape Regulation by the Glycocalyx

(2019) Carolyn R. Shurer et al.   CELL

Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis

(2019) Elizabeth Ann Hambleton et al.   eLife

A Review of Plant Vacuoles: Formation, Located Proteins, and Functions

(2019) Xiaona Tan et al.   Plants-Basel

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

(2019) Mikael B.L. Winkler et al.   CELL

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

(2019) D. Höglinger et al.   Nature Communications

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

(2019) Leslie A McCauliff et al.   eLife

The wide‐ranging phenotypes of ergosterol biosynthesis mutants, and implications for microbial cell factories

(2019) Emily J. Johnston et al.   YEAST

Budding Yeast Has a Minimal Endomembrane System

(2018) Kasey J. Day et al.   DEVELOPMENTAL CELL

Lipid droplet-mediated lipid and protein homeostasis in budding yeast

(2018) Martin Graef   FEBS LETTERS

Lipid droplet autophagy during energy mobilization lipid homeostasis and protein quality control

(2018) Liza A Pon   Frontiers in Bioscience-Landmark

N-glycome of the Lysosomal Glycocalyx is Altered in Niemann-Pick Type C Disease (NPC) Model Cells

(2018) Marko Kosicek et al.   MOLECULAR & CELLULAR PROTEOMICS

Multidrug efflux pumps: structure, function and regulation

(2018) Dijun Du et al.   NATURE REVIEWS MICROBIOLOGY

molecular mechanisms of AcrB-mediated multidrug export

(2018) martijn zwama et al.   RESEARCH IN MICROBIOLOGY

RND transporters in the living world

(2018) Hiroshi Nikaido   RESEARCH IN MICROBIOLOGY

Structural basis for the recognition of Sonic Hedgehog by human Patched1

(2018) Xin Gong et al.   SCIENCE

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

(2018) Xiaofeng Qi et al.   NATURE

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

(2018) Michael Nguyen Trinh et al.   eLife

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae

(2017) Zhihong Hu et al.   INDIAN JOURNAL OF MICROBIOLOGY

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport

(2017) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium

(2017) Benjamin R. Myers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

(2017) Takuma Tsuji et al.   eLife

Exocytosis of Endothelial Lysosome-Related Organelles Hair-Triggers a Patchy Loss of Glycocalyx at the Onset of Sepsis

(2016) Joseph A. Zullo et al.   AMERICAN JOURNAL OF PATHOLOGY

Cholesterol Biosynthesis: A Mechanistic Overview

(2016) Nuno M. F. S. A. Cerqueira et al.   BIOCHEMISTRY

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

(2016) Han Wang et al.   CELL

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

(2016) Yuguang Zhao et al.   FEBS LETTERS

Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations

(2016) Ogun Adebali et al.   GENETICS IN MEDICINE

The glycocalyx and its significance in human medicine

(2016) J. M. Tarbell et al.   JOURNAL OF INTERNAL MEDICINE

Structure of human Niemann–Pick C1 protein

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misexpression of the Niemann-Pick disease type C1 (NPC1)-like protein in Arabidopsis causes sphingolipid accumulation and reproductive defects

(2015) Maximilian J. Feldman et al.   PLANTA

Structural basis of RND-type multidrug exporters

(2015) Akihito Yamaguchi et al.   Frontiers in Microbiology

The Structural Role of Cholesterol in Cell Membranes: From Condensed Bilayers to Lipid Rafts

(2014) Martin R. Krause et al.   ACCOUNTS OF CHEMICAL RESEARCH

Yeast lipid metabolism at a glance

(2014) Lisa Klug et al.   FEMS YEAST RESEARCH

All-Trans Retinoic Acid-Triggered Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on NPC2

(2014) M. Wheelwright et al.   JOURNAL OF IMMUNOLOGY

Niemann-Pick type C2 protein mediating chemical communication in the worker ant

(2014) Y. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the mechanisms of sterol transport between organelles

(2013) Bruno Mesmin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae

(2013) Tim van Zutphen et al.   MOLECULAR BIOLOGY OF THE CELL

Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1

(2013) Rita Vilaça et al.   MOLECULAR MICROBIOLOGY

Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

(2013) Sovan Sarkar et al.   Cell Reports

Porter domain opening and closing motions in the multi-drug efflux transporter AcrB

(2012) Nadine Fischer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid Droplets and Peroxisomes: Key Players in Cellular Lipid Homeostasis or A Matter of Fat--Store 'em Up or Burn 'em Down

(2012) S. D. Kohlwein et al.   GENETICS

The Hedgehog Receptor Patched Functions in Multidrug Transport and Chemotherapy Resistance

(2012) M. Bidet et al.   MOLECULAR CANCER RESEARCH

Biosynthesis of Cholesterol and Other Sterols

(2011) W. David Nes   CHEMICAL REVIEWS

Altered vitamin E status in Niemann-Pick type C disease

(2011) L. Ulatowski et al.   JOURNAL OF LIPID RESEARCH

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

The Hedgehog Receptor Patched Is Involved in Cholesterol Transport

(2011) Michel Bidet et al.   PLoS One

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

(2011) M. S. Deffieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of evolutionarily conserved genetic regulators of cellular aging

(2010) Gerhard T. Laschober et al.   AGING CELL

Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes

(2010) Michael L. Wang et al.   Cell Metabolism

Mechanisms of sterol uptake and transport in yeast

(2010) Nicolas Jacquier et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ultrastructural Imaging of Candida albicans Adhesion to Rat Genital Epithelium through Scanning and Transmission Electron Microscopy

(2010) Edilson Damke et al.   MICROSCOPY AND MICROANALYSIS

Lipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease

(2010) Emyr Lloyd-Evans et al.   TRAFFIC

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hedgehog Signaling Pathway: Where Did It Come From?

(2009) George Hausmann et al.   PLOS BIOLOGY

The yeast lysosome-like vacuole: Endpoint and crossroads

(2008) Sheena Claire Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Vacuolar and Plasma Membrane Proton Pumps Collaborate to Achieve Cytosolic pH Homeostasis in Yeast

(2008) Gloria A. Martínez-Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

(2008) R. E. Infante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NPC1/NPC2 function as a tag team duo to mobilize cholesterol

(2008) K. Subramanian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA