Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system

Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation

(2021) Debora Giunti et al.   Scientific Reports

MiR-17–92 Cluster-Enriched Exosomes Derived from Human Bone Marrow Mesenchymal Stromal Cells Improve Tissue and Functional Recovery in Rats after Traumatic Brain Injury

(2021) Yanlu Zhang et al.   JOURNAL OF NEUROTRAUMA

Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type II Diabetic Mice

(2020) Lei Wang et al.   DIABETES

Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice

(2020) Sharmilla Devi Jayasingam et al.   Frontiers in Oncology

CD133+Exosome Treatment Improves Cardiac Function after Stroke in Type 2 Diabetic Mice

(2020) Poornima Venkat et al.   Translational Stroke Research

Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

(2020) Kasra Asgarpour et al.   Cell Communication and Signaling

Exosome-based candidates move into the clinic

(2020) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain

(2020) Dan Benjamini et al.   BRAIN

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

(2019) Zheng Gang Zhang et al.   Nature Reviews Neurology

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

(2019) Milad Riazifar et al.   ACS Nano

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

(2019) Benjamin Schattling et al.   NATURE NEUROSCIENCE

MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis

(2019) Jing Zhang et al.   NEUROBIOLOGY OF DISEASE

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

(2019) Marta Lombardi et al.   ACTA NEUROPATHOLOGICA

The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases

(2019) Armita Mahdavi Gorabi et al.   MOLECULAR NEUROBIOLOGY

Central nervous system regeneration is driven by microglia necroptosis and repopulation

(2019) Amy F. Lloyd et al.   NATURE NEUROSCIENCE

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

(2019) David Kremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

(2019) Baoyan Fan et al.   DIABETOLOGIA

Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system

(2019) Shailesh K. Shahi et al.   Scientific Reports

Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection and Improve Long-Term Neurologic Outcomes in a Swine Model of Traumatic Brain Injury and Hemorrhagic Shock

(2018) Aaron M Williams et al.   JOURNAL OF NEUROTRAUMA

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

(2018) Scott W. Ferguson et al.   Scientific Reports

Cell-Based and Exosome Therapy in Diabetic Stroke

(2018) Poornima Venkat et al.   Stem Cells Translational Medicine

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

(2018) Sara E. Nasrabady et al.   Acta Neuropathologica Communications

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease

(2018) Edwin E. Reza-Zaldivar et al.   Frontiers in Cellular Neuroscience

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

(2018) Yuyi You et al.   BRAIN

Role of Microglia TLRs in Neurodegeneration

(2018) Bernd L. Fiebich et al.   Frontiers in Cellular Neuroscience

Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia

(2018) Zijian Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Drug discovery for remyelination and treatment of MS

(2017) Katy L. H. Cole et al.   GLIA

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function

(2017) Daniel Ontaneda et al.   LANCET

Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis

(2017) Jeffrey A Cohen et al.   Multiple Sclerosis Journal

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

Remyelination therapies: a new direction and challenge in multiple sclerosis

(2017) Jason R. Plemel et al.   NATURE REVIEWS DRUG DISCOVERY

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury

(2017) Yanlu Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

MiR-146a promotes remyelination in a cuprizone model of demyelinating injury

(2017) Jing Zhang et al.   NEUROSCIENCE

Clarifying Stem-Cell Therapy’s Benefits and Risks

(2017) Peter W. Marks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

(2017) Donald G. Phinney et al.   STEM CELLS

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

Transplanted miR-219-overexpressing oligodendrocyte precursor cells promoted remyelination and improved functional recovery in a chronic demyelinated model

(2017) Hong-Bin Fan et al.   Scientific Reports

Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis

(2017) Jeffrey A Cohen et al.   Multiple Sclerosis Journal

Clinical safety of intrathecal administration of mesenchymal stromal cell–derived neural progenitors in multiple sclerosis

(2016) Violaine K. Harris et al.   CYTOTHERAPY

Exosomes in stroke pathogenesis and therapy

(2016) Zheng Gang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-146a Promotes Oligodendrogenesis in Stroke

(2016) Xian Shuang Liu et al.   MOLECULAR NEUROBIOLOGY

Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons

(2016) Yi Zhang et al.   MOLECULAR NEUROBIOLOGY

Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system

(2016) Jing Zhang et al.   NEUROBIOLOGY OF DISEASE

MicroRNA 146a locally mediates distal axonal growth of dorsal root ganglia neurons under high glucose and sildenafil conditions

(2016) Longfei Jia et al.   NEUROSCIENCE

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

(2015) Stella Kourembanas   Annual Review of Physiology

Emerging potential of exosomes and noncoding microRNAs for the treatment of neurological injury/diseases

(2015) Michael Chopp et al.   EXPERT OPINION ON EMERGING DRUGS

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

(2015) Fadi J. Najm et al.   NATURE

Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis

(2015) Jing Zhang et al.   NEUROBIOLOGY OF DISEASE

Why primate models matter

(2014) Kimberley A. Phillips et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Thymosin β4 Up-regulation of MicroRNA-146a Promotes Oligodendrocyte Differentiation and Suppression of the Toll-like Proinflammatory Pathway

(2014) Manoranjan Santra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

(2014) Manuel A. Friese et al.   Nature Reviews Neurology

Outsmart tumor exosomes to steal the cancer initiating cell its niche

(2014) Florian Thuma et al.   SEMINARS IN CANCER BIOLOGY

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis

(2013) Khalil S. Rawji et al.   Clinical & Developmental Immunology

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

(2013) Anuradha Kalani et al.   MOLECULAR NEUROBIOLOGY

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy

(2013) L. Wang et al.   NEUROSCIENCE

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Microvesicles and intercellular communication in the context of parasitism

(2013) Natasha S. Barteneva et al.   Frontiers in Cellular and Infection Microbiology

Sex and gender issues in multiple sclerosis

(2013) Hanne F. Harbo et al.   Therapeutic Advances in Neurological Disorders

Combination Therapy With VELCADE and Tissue Plasminogen Activator Is Neuroprotective in Aged Rats After Stroke and Targets MicroRNA-146a and the Toll-Like Receptor Signaling Pathway

(2012) Li Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

(2012) Saumya Pant et al.   BIOCHEMICAL PHARMACOLOGY

Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Aberrant Emotional and Social Behaviors

(2012) Roopali Yadav et al.   PLoS One

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Safety of Mesenchymal Stem Cells for Clinical Application

(2012) Youwei Wang et al.   Stem Cells International

The complex world of oligodendroglial differentiation inhibitors

(2011) David Kremer et al.   ANNALS OF NEUROLOGY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of remyelination in multiple sclerosis

(2011) Khalid A. Hanafy et al.   FEBS LETTERS

Risk factors in the development of stem cell therapy

(2011) Carla A Herberts et al.   Journal of Translational Medicine

Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases

(2011) Antonio Uccelli et al.   LANCET NEUROLOGY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication

(2011) Andrew J. Steelman et al.   NEUROSCIENCE RESEARCH

Adverse Effects of Bone Marrow Stromal Cell Treatment of Stroke in Diabetic Rats

(2011) Jieli Chen et al.   STROKE

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The life, death, and replacement of oligodendrocytes in the adult CNS

(2008) Dana M. McTigue et al.   JOURNAL OF NEUROCHEMISTRY

Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis

(2008) R. Aharoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA